Author

Daniel P. Walker

Observed names: Daniel P. Walker, Daniel Walker

Observed institutions: Eli Lilly (United States), Pfizer (United States), University of Washington, Curtin University, Montana State University, Zoetis (United States), Queen Elizabeth II Medical Centre, Ear Science Institute Australia

ORCID: 0000-0002-1332-4392

Observed ORCID: 0000-0002-1332-4392

OpenAlex ID: A5037232270

Structural Alert/Reactive Metabolite Concept as Applied in Medicinal Chemistry to Mitigate the Risk of Idiosyncratic Drug Toxicity: A Perspective Based on the Critical Examination of Trends in the Top 200 Drugs Marketed in the United States

2011 · Antonia F. Stepan, Daniel P. Walker, et al. · Chemical Research in Toxicology · 710

Discovery ofN-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide, an Agonist of the α7 Nicotinic Acetylcholine Receptor, for the Potential Treatment of Cognitive Deficits in Schizophrenia: Synthesis and Structure−Activity Relationship

2006 · Donn G. Wishka, Daniel P. Walker, et al. · Journal of Medicinal Chemistry · 193

Structural Characterization of Proline-rich Tyrosine Kinase 2 (PYK2) Reveals a Unique (DFG-out) Conformation and Enables Inhibitor Design

2009 · Seungil Han, Anil Mistry, et al. · Journal of Biological Chemistry · 110

Design, synthesis, structure–activity relationship, and in vivo activity of azabicyclic aryl amides as α7 nicotinic acetylcholine receptor agonists

2006 · Daniel P. Walker, Donn G. Wishka, et al. · Bioorganic & Medicinal Chemistry · 95

Novel Riboswitch-Binding Flavin Analog That Protects Mice against Clostridium difficile Infection without Inhibiting Cecal Flora

2015 · Kenneth F. Blount, Cynthia Megyola, et al. · Antimicrobial Agents and Chemotherapy · 94

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Sulfoximine-substituted trifluoromethylpyrimidine analogs as inhibitors of proline-rich tyrosine kinase 2 (PYK2) show reduced hERG activity

2009 · Daniel P. Walker, Michael P. Zawistoski, et al. · Bioorganic & Medicinal Chemistry Letters · 88

Discovery of N-[(3R,5R)-1-azabicyclo[3.2.1]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide as an agonist of the α7 nicotinic acetylcholine receptor: In vitro and in vivo activity

2008 · Brad A. Acker, E. Jon Jacobsen, et al. · Bioorganic & Medicinal Chemistry Letters · 61

Trifluoromethylpyrimidine-based inhibitors of proline-rich tyrosine kinase 2 (PYK2): Structure–activity relationships and strategies for the elimination of reactive metabolite formation

2008 · Daniel P. Walker, F. Christopher Bi, et al. · Bioorganic & Medicinal Chemistry Letters · 57

Discovery and Preclinical Characterization of 1-Methyl-3-(4-methylpyridin-3-yl)-6-(pyridin-2-ylmethoxy)-1 H -pyrazolo-[3,4- b ]pyrazine (PF470): A Highly Potent, Selective, and Efficacious Metabotropic Glutamate Receptor 5 (mGluR5) Negative Allosteric Modulator

2014 · Lei Zhang, Gayatri Balan, et al. · Journal of Medicinal Chemistry · 53

Discovery and SAR of PF-4693627, a potent, selective and orally bioavailable mPGES-1 inhibitor for the potential treatment of inflammation

2012 · Graciela B. Arhancet, Daniel P. Walker, et al. · Bioorganic & Medicinal Chemistry Letters · 49

Aminopyrazole Carboxamide Bruton’s Tyrosine Kinase Inhibitors. Irreversible to Reversible Covalent Reactive Group Tuning

2018 · Mark E. Schnute, Stephen E. Benoit, et al. · ACS Medicinal Chemistry Letters · 30

Synthesis and biological evaluation of substituted benzoxazoles as inhibitors of mPGES-1: Use of a conformation-based hypothesis to facilitate compound design

2012 · Daniel P. Walker, Graciela B. Arhancet, et al. · Bioorganic & Medicinal Chemistry Letters · 28

Discovery Tactics To Mitigate Toxicity Risks Due to Reactive Metabolite Formation with 2-(2-Hydroxyaryl)-5-(trifluoromethyl)pyrido[4,3-d]pyrimidin-4(3H)-one Derivatives, Potent Calcium-Sensing Receptor Antagonists and Clinical Candidate(s) for the Treatment of Osteoporosis

2010 · Amit S. Kalgutkar, David A. Griffith, et al. · Chemical Research in Toxicology · 25

Short-acting 5-(trifluoromethyl)pyrido[4,3-d]pyrimidin-4(3H)-one derivatives as orally-active calcium-sensing receptor antagonists

2009 · Mary T. Didiuk, David A. Griffith, et al. · Bioorganic & Medicinal Chemistry Letters · 25

Utility of MetaSite in Improving Metabolic Stability of the Neutral Indomethacin Amide Derivative and Selective Cyclooxygenase-2 Inhibitor 2-(1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl)-N-phenethyl-acetamide

2009 · David Boyer, Jonathan N. Bauman, et al. · Drug Metabolism and Disposition · 25

Identification of novel series of pyrazole and indole-urea based DFG-out PYK2 inhibitors

2012 · Samit K. Bhattacharya, Gary E. Aspnes, et al. · Bioorganic & Medicinal Chemistry Letters · 17

Novel syntheses of 3-anilino-pyrazin-2(1H)-ones and 3-anilino-quinoxalin-2-(1H)-ones via microwave-mediated Smiles rearrangement

2008 · F. Christopher Bi, Gary E. Aspnes, et al. · Tetrahedron Letters · 16

Single-Cellular Biological Effects of Cholesterol-Catabolic Bile Acid-Based Nano/Micro Capsules as Anti-Inflammatory Cell Protective Systems

2022 · Armin Mooranian, Corina Mihaela Ionescu, et al. · Biomolecules · 15

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Three step, one-pot process to prepare thiophene-2-carbonyl chloride (TCC), a key raw material in the manufacture of tioxazafen (Nemastrike®)

2019 · Daniel P. Walker, Charles R. Graham, et al. · Tetrahedron Letters · 14

Total Synthesis of 5(R)- and 5(S)-Polyandrane

1999 · Daniel P. Walker, Paul A. Grieco · Journal of the American Chemical Society · 12

Differences in CYP3A4 catalyzed bioactivation of 5-aminooxindole and 5-aminobenzsultam scaffolds in proline-rich tyrosine kinase 2 (PYK2) inhibitors: Retrospective analysis by CYP3A4 molecular docking, quantum chemical calculations and glutathione adduct detection using linear ion trap/orbitrap mass spectrometry

2009 · Hao Sun, Raman Sharma, et al. · Bioorganic & Medicinal Chemistry Letters · 10

Preparation of novel azabicyclic amines and α7 nicotinic acetylcholine receptor activity of derived aryl amides

2008 · Daniel P. Walker, Brad A. Acker, et al. · Journal of Heterocyclic Chemistry · 10

Discovery and Characterization of (R)-6-Neopentyl-2-(pyridin-2-ylmethoxy)-6,7-dihydropyrimido[2,1-c][1,4]oxazin-4(9H)-one (PF-06462894), an Alkyne-Lacking Metabotropic Glutamate Receptor 5 Negative Allosteric Modulator Profiled in both Rat and Nonhuman Primates

2017 · Antonia F. Stepan, Michelle M. Claffey, et al. · Journal of Medicinal Chemistry · 9

A Practical Synthesis of [(1S,3S)-3-Aminocyclohexyl]methanol and 2-[(1S,3S)-3-Aminocyclohexyl]propan-2-ol, Useful Intermediates for the Preparation of Novel mPGES-1 Inhibitors

2011 · Daniel Walker, Steven Heasley, et al. · Synlett · 8

Synthesis of (±)-8-Oxa-3-azabicyclo[3.2.1]octan-2-thione and (±)-2-Oxa-5-azabicyclo[2.2.1]heptan-6-thione: Potential Synthons for the Preparation of Novel Heteroaryl-Annulated Bicyclic Morpholines

2011 · Daniel Walker, Donn Wishka, et al. · Synthesis · 7

Works count: 43

Citation count: 1,794

H-index: 16

I10-index: 22