Author

Thomas W. Patapoff

Observed names: T W Patapoff, T. PATAPOFF, T. Patapoff, T. W. PATAPOFF, T. W. Patapoff, T.W. Patapoff, Thomas Patapoff, Thomas W Patapoff

Institution: Genentech

Observed institutions: Brigham and Women's Hospital, Roche (United States), Harvard University, University of Oregon, Genentech, University of Chicago, Pharmaceutical Product Development (India), Gilead Sciences (United States), Lockheed Missiles and Space Company (United States), Lockheed (United States), Stanford University

OpenAlex ID: A5037603859

Reversible Self-Association of a Concentrated Monoclonal Antibody Solution Mediated by Fab–Fab Interaction That Impacts Solution Viscosity

2008 · Sonoko Kanai, Jun Liu, et al. · Journal of Pharmaceutical Sciences · 305

5'-adenosine monophosphate is the neutrophil-derived paracrine factor that elicits chloride secretion from T84 intestinal epithelial cell monolayers.

1993 · J L Madara, T W Patapoff, et al. · Journal of Clinical Investigation · 285

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In silico selection of therapeutic antibodies for development: Viscosity, clearance, and chemical stability

2014 · Vikas K. Sharma, Thomas W. Patapoff, et al. · Proceedings of the National Academy of Sciences · 255

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Auristatin Antibody Drug Conjugate Physical Instability and the Role of Drug Payload

2014 · Yilma T. Adem, Kelly A. Schwarz, et al. · Bioconjugate Chemistry · 204

Surface expression, polarization, and functional significance of CD73 in human intestinal epithelia.

1997 · G R Strohmeier, W I Lencer, et al. · Journal of Clinical Investigation · 175

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A novel in vitro method to model the fate of subcutaneously administered biopharmaceuticals and associated formulation components

2015 · Hanne M. Kinnunen, Vikas Sharma, et al. · Journal of Controlled Release · 124

Lyophilization of protein formulations in vials: Investigation of the relationship between resistance to vapor flow during primary drying and small‐scale product collapse

1999 · David E. Overcashier, Thomas W. Patapoff, et al. · Journal of Pharmaceutical Sciences · 115

Mutational landscape of antibody variable domains reveals a switch modulating the interdomain conformational dynamics and antigen binding

2017 · Patrick Koenig, Chingwei V. Lee, et al. · Proceedings of the National Academy of Sciences · 114

Coarse-Grained Modeling of the Self-Association of Therapeutic Monoclonal Antibodies

2012 · Anuj Chaudhri, Isidro E. Zarraga, et al. · The Journal of Physical Chemistry B · 113

Effects of Reducing Sugars on the Chemical Stability of Human Relaxin in the Lyophilized State

1996 · Shihong Li, Thomas W. Patapoff, et al. · Journal of Pharmaceutical Sciences · 109

Kinetics and Thermodynamics of Dimer Formation and Dissociation for a Recombinant Humanized Monoclonal Antibody to Vascular Endothelial Growth Factor

1999 · Jamie M. R. Moore, Thomas W. Patapoff, et al. · Biochemistry · 108

Polysorbate 20 prevents the precipitation of a monoclonal antibody during shear

2009 · Thomas W. Patapoff, Osigwe Esue · Pharmaceutical Development and Technology · 95

Construction, MD Simulation, and Hydrodynamic Validation of an All-Atom Model of a Monoclonal IgG Antibody

2010 · J. Paul Brandt, Thomas W. Patapoff, et al. · Biophysical Journal · 93

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In vitro model for predicting bioavailability of subcutaneously injected monoclonal antibodies

2018 · Hanne Kinnunen Bown, Catherine Bonn, et al. · Journal of Controlled Release · 91

The Role of Amino Acid Sequence in the Self-Association of Therapeutic Monoclonal Antibodies: Insights from Coarse-Grained Modeling

2013 · Anuj Chaudhri, Isidro E. Zarraga, et al. · The Journal of Physical Chemistry B · 90

Protein Aggregation in Frozen Trehalose Formulations: Effects of Composition, Cooling Rate, and Storage Temperature

2015 · Brian D. Connolly, Lan Le, et al. · Journal of Pharmaceutical Sciences · 76

Improving pH gradient cation-exchange chromatography of monoclonal antibodies by controlling ionic strength

2012 · Liangyi Zhang, Thomas Patapoff, et al. · Journal of Chromatography A · 75

Cold denaturation of monoclonal antibodies

2010 · Kristi L. Lazar, Thomas W. Patapoff, et al. · mAbs · 70

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Influence of glycosylation pattern on the molecular properties of monoclonal antibodies

2014 · Kai Zheng, Mark Yarmarkovich, et al. · mAbs · 69

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Crystallization of Trehalose in Frozen Solutions and its Phase Behavior during Drying

2010 · Prakash Sundaramurthi, Thomas W. Patapoff, et al. · Pharmaceutical Research · 69

Raman spectra of the model B-DNA oligomer d(CGCGAATTCGCG)2 and of the DNA in living salmon sperm show that both have very similar B-type conformations

1986 · William L. Kubasek, Yang Wang, et al. · Biochemistry · 61

Laser Raman Microscopy of Chromosomes in Living Eukaryotic Cells: DNA Polymorphism In Vivo

1996 · W. L. Peticolas, T. W. Patapoff, et al. · Journal of Raman Spectroscopy · 60

The Effect of Benzyl Alcohol on Recombinant Human Interferon-γ

1997 · Xanthe M. Lam, Thomas W. Patapoff, et al. · Pharmaceutical Research · 55

Trehalose Limits BSA Aggregation in Spray-Dried Formulations at High Temperatures: Implications in Preparing Polymer Implants for Long-Term Protein Delivery

2013 · Karthikan Rajagopal, Joseph Wood, et al. · Journal of Pharmaceutical Sciences · 49

Activated eosinophils evoke chloride secretion in model intestinal epithelia primarily via regulated release of 5'-AMP.

1993 · M B Resnick, S P Colgan, et al. · The Journal of Immunology · 46

Works count: 67

Citation count: 3,677

H-index: 33

I10-index: 55