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Charles H. Large

Observed names: C Large, C. H. Large, C. LARGE, C. Large, C.H Large, C.H. Large, Charles H Large, Charles Large, Charles H. Large, Large, Charles, Large, Charles H.
Observed institutions: Instytut Biologii Doświadczalnej im. Marcelego Nenckiego, GlaxoSmithKline (United Kingdom), University of Cambridge, Autifony Therapeutics (United Kingdom), Stevenage Bioscience Catalyst, Biogen (United Kingdom), GlaxoSmithKline (Italy), Aptuit (Italy), Université Nice Sophia Antipolis, Imperial College London
ORCID: 0000-0001-9814-7737
Observed ORCID: 0000-0001-9814-7737
OpenAlex ID: A5037742036
State of the art: Pharmacologic effects on cortical excitability measures tested by transcranial magnetic stimulation
2008 · Walter Paulus, Joseph Classen, et al. · Brain stimulation · 429
The mechanism of action of retigabine (ezogabine), a first‐in‐class K + channel opener for the treatment of epilepsy
2012 · Martin J. Gunthorpe, Charles H. Large, et al. · Epilepsia · 333
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Why Is There No Cure for Tinnitus?
2019 · Don J. McFerran, David Stockdale, et al. · Frontiers in Neuroscience · 215
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Investigation of the effects of lamotrigine and clozapine in improving reversal-learning impairments induced by acute phencyclidine and d-amphetamine in the rat
2005 · N. F. Idris, P. Repeto, et al. · Psychopharmacology · 124
Behavioural, physiological and morphological analysis of a line of apolipoprotein E knockout mouse
1998 · R. Anderson, J.C. Barnes, et al. · Neuroscience · 122
Lamotrigine as Add-On Therapy in Schizophrenia: Results of 2 Placebo-Controlled Trials
2007 · Donald C. Goff, Richard Keefe, et al. · Journal of Clinical Psychopharmacology · 121
Differential Effects of Antipsychotic and Glutamatergic Agents on the phMRI Response to Phencyclidine
2007 · Alessandro Gozzi, Charles H Large, et al. · Neuropsychopharmacology · 114
Acoustic over-exposure triggers burst firing in dorsal cochlear nucleus fusiform cells
2011 · Nadia Pilati, Charles Large, et al. · Hearing Research · 98
Do NMDA receptor antagonist models of schizophrenia predict the clinical efficacy of antipsychotic drugs?
2007 · Charles H. Large · Journal of Psychopharmacology · 95
Evaluation of the effects of lamotrigine, valproate and carbamazepine in a rodent model of mania
2004 · Roberto Arban, Gabriella Maraia, et al. · Behavioural Brain Research · 94
Interleaved Transcranial Magnetic Stimulation/Functional MRI Confirms that Lamotrigine Inhibits Cortical Excitability in Healthy Young Men
2004 · Xingbao Li, Charlotte C Tenebäck, et al. · Neuropsychopharmacology · 91
Effects of lamotrigine and levetiracetam on seizure development in a rat amygdala kindling model
2003 · Sharon C Stratton, Charles H Large, et al. · Epilepsy Research · 91
Chronic stress‐induced alterations in amygdala responsiveness and behavior – modulation by trait anxiety and corticotropin‐releasing factor systems
2008 · Carmen Sandi, M. Isabel Cordero, et al. · European Journal of Neuroscience · 87
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Increased expression of dendritic mRNA following the induction of long-term potentiation
1998 · L.A Roberts, C.H Large, et al. · Molecular Brain Research · 83
The spectrum of anticonvulsant efficacy of retigabine (ezogabine) in animal models: Implications for clinical use
2012 · Charles H. Large, David M. Sokal, et al. · Epilepsia · 78
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Kv3.3 Channels Bind Hax-1 and Arp2/3 to Assemble a Stable Local Actin Network that Regulates Channel Gating
2016 · Yalan Zhang, Xiao-Feng Zhang, et al. · Cell · 75
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Lamotrigine prevents ketamine but not amphetamine-induced deficits in prepulse inhibition in mice
2003 · Suzanne A. Brody, Mark A. Geyer, et al. · Psychopharmacology · 68
The potential role of lamotrigine in schizophrenia
2005 · Charles H. Large, Elizabeth L. Webster, et al. · Psychopharmacology · 67
A Novel Modulator of Kv3 Potassium Channels Regulates the Firing of Parvalbumin-Positive Cortical Interneurons
2015 · Marcelo D. Rosato-Siri, Erika Zambello, et al. · Journal of Pharmacology and Experimental Therapeutics · 66
Intraventricular Infusion of Apolipoprotein E Ameliorates Acute Neuronal Damage after Global Cerebral Ischemia in Mice
2000 · Karen Horsburgh, James McCulloch, et al. · Journal of Cerebral Blood Flow & Metabolism · 66
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Apolipoprotein E and Alzheimer's Disease: A Review of Recent Studies
1997 · Guy A Higgins, Charles H Large, et al. · Pharmacology Biochemistry and Behavior · 58
Modulators of Kv3 Potassium Channels Rescue the Auditory Function of Fragile X Mice
2019 · Lynda El-Hassar, Lei Song, et al. · Journal of Neuroscience · 56
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Mechanisms contributing to central excitability changes during hearing loss
2012 · Nadia Pilati, Matias J. Ison, et al. · Proceedings of the National Academy of Sciences · 56
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Electrophysiological characterisation of the dentate gyrus in five inbred strains of mouse
1999 · Edward T.W Bampton, Roy A Gray, et al. · Brain Research · 50
A novel series of arylpiperazines with high affinity and selectivity for the dopamine D3 receptor
1995 · P. John Murray, Lee A. Harrison, et al. · Bioorganic & Medicinal Chemistry Letters · 49
Works count: 109
Citation count: 3,751
H-index: 33
I10-index: 59
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