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Hiroyuki Kakinuma

Observed names: H. KAKINUMA, H. Kakinuma, Hiroyuki KAKINUMA
Observed institutions: Tokyo Institute of Technology, Taisho Pharmaceutical (Japan), Japan Tobacco (Japan), Eisai (Japan), Yokohama City University, University of Sheffield
ORCID: 0000-0002-2490-2530
Observed ORCID: 0000-0002-2490-2530
OpenAlex ID: A5038079325
(1 S )-1,5-Anhydro-1-[5-(4-ethoxybenzyl)-2-methoxy-4-methylphenyl]-1-thio- d -glucitol (TS-071) is a Potent, Selective Sodium-Dependent Glucose Cotransporter 2 (SGLT2) Inhibitor for Type 2 Diabetes Treatment
2010 · Hiroyuki Kakinuma, Takahiro Oi, et al. · Journal of Medicinal Chemistry · 163
Development of a Method for Evaluating Drug-Likeness and Ease of Synthesis Using a Data Set in Which Compounds Are Assigned Scores Based on Chemists' Intuition
2003 · Yuji Takaoka, Yutaka Endo, et al. · Journal of Chemical Information and Computer Sciences · 99
Pyrazole and Isoxazole Derivatives as New, Potent, and Selective 20-Hydroxy-5,8,11,14-eicosatetraenoic Acid Synthase Inhibitors
2003 · Toshio Nakamura, Masakazu Sato, et al. · Journal of Medicinal Chemistry · 78
Imidazole derivatives as new potent and selective 20-HETE synthase inhibitors
2003 · Toshio Nakamura, Hiroyuki Kakinuma, et al. · Bioorganic & Medicinal Chemistry Letters · 69
In vitro abzyme evolution to optimize antibody recognition for catalysis
2001 · Naoko Takahashi, Hiroyuki Kakinuma, et al. · Nature Biotechnology · 65
Synthesis and Antifungal Activity of Novel Thiazole-Containing Triazole Antifungals. II. Optically Active ER-30346 and Its Derivatives.
1998 · Akihiko TSURUOKA, Yumiko KAKU, et al. · Chemical and Pharmaceutical Bulletin · 50
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Synthesis and Antifungal Activity of Novel Thiazole-Containing Triazole Antifungals.
1997 · Akihiko TSURUOKA, Yumiko KAKU, et al. · Chemical and Pharmaceutical Bulletin · 35
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A Novel Route for Chiral Synthesis of the Triazole Antifungal ER-30346.
1998 · Yumiko KAKU, Akihiko TSURUOKA, et al. · Chemical and Pharmaceutical Bulletin · 30
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Discovery of Aryloxyphenyl–Heptapeptide Hybrids as Potent and Selective Matrix Metalloproteinase-2 Inhibitors for the Treatment of Idiopathic Pulmonary Fibrosis
2022 · Tomoki Takeuchi, Masato Hayashi, et al. · Journal of Medicinal Chemistry · 27
Discovery of TP0597850: A Selective, Chemically Stable, and Slow Tight-Binding Matrix Metalloproteinase-2 Inhibitor with a Phenylbenzamide–Pentapeptide Hybrid Scaffold
2023 · Tomoki Takeuchi, Yusaku Nomura, et al. · Journal of Medicinal Chemistry · 23
Design and synthesis of 1H-pyrazolo[3,4-c]pyridine derivatives as a novel structural class of potent GPR119 agonists
2016 · Daisuke Matsuda, Yohei Kobashi, et al. · Bioorganic & Medicinal Chemistry Letters · 20
Selective chemotherapeutic strategies using catalytic antibodies: a common pro-moiety for antibody-directed abzyme prodrug therapy
2002 · Hiroyuki Kakinuma, Ikuo Fujii, et al. · Journal of Immunological Methods · 20
Novel 3H-[1,2,3]triazolo[4,5-c]pyridine derivatives as GPR119 agonists: Synthesis and structure-activity/solubility relationships
2017 · Daisuke Matsuda, Yohei Kobashi, et al. · Bioorganic & Medicinal Chemistry · 18
Improved generation of catalytic antibodies by MRL/MPJ-lpr/lpr autoimmune mice
2000 · Naoko Takahashi, Hiroyuki Kakinuma, et al. · Journal of Immunological Methods · 17
Discovery of potent, low-absorbable sodium-dependent glucose cotransporter 1 (SGLT1) inhibitor SGL5213 for type 2 diabetes treatment
2018 · Shoichi Kuroda, Yohei Kobashi, et al. · Bioorganic & Medicinal Chemistry · 16
Efficient screening for catalytic antibodies using a short transition‐state analog and detailed characterization of selected antibodies
1999 · Naoko Takahashi, Hiroyuki Kakinuma, et al. · European Journal of Biochemistry · 16
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Comparison of phosphonate transition state analogs for inducing catalytic antibodies and evaluation of key structural factors by an ab initio study
1999 · Hiroyuki Kakinuma, Kazuko Shimazaki, et al. · Tetrahedron · 15
Glycosyltransfer mechanism of α-glucosyltransferase from Protaminobacter rubrum
1998 · Hiroyuki Kakinuma, Hideya Yuasa, et al. · Carbohydrate Research · 15
Discovery of a potent, low-absorbable sodium-dependent glucose cotransporter 1 (SGLT1) inhibitor (TP0438836) for the treatment of type 2 diabetes
2018 · Shoichi Kuroda, Yohei Kobashi, et al. · Bioorganic & Medicinal Chemistry Letters · 14
High-resolution Crystal Structure of the Fab-fragments of a Family of Mouse Catalytic Antibodies with Esterase Activity
2003 · Sergey N. Ruzheinikov, Tatyana A. Muranova, et al. · Journal of Molecular Biology · 14
Discovery of novel 2-[(4-hydroxy-6-oxo-2,3-dihydro-1H-pyridine-5-carbonyl)amino]acetic acid derivatives as HIF prolyl hydroxylase inhibitors for treatment of renal anemia
2018 · Makoto Hamada, Tetsuo Takayama, et al. · Bioorganic & Medicinal Chemistry Letters · 13
Design, synthesis and biological evaluation of novel 7-azaspiro[3.5]nonane derivatives as GPR119 agonists
2018 · Daisuke Matsuda, Madoka Kawamura, et al. · Bioorganic & Medicinal Chemistry · 13
Structure–activity relationships of novel piperazines as antagonists for the melanocortin-4 receptor
2006 · Dai Nozawa, Taketoshi Okubo, et al. · Bioorganic & Medicinal Chemistry · 13
Lead identification of novel tetrahydroimidazo[1,2-a]pyridine-5-carboxylic acid derivative as a potent heparanase-1 inhibitor
2022 · Yudai Imai, Daisuke Wakasugi, et al. · Bioorganic & Medicinal Chemistry Letters · 12
Directed evolution governed by controlling the molecular recognition between an abzyme and its haptenic transition–state analog
2004 · Naoko Takahashi-Ando, Hiroyuki Kakinuma, et al. · Journal of Immunological Methods · 10
Works count: 55
Citation count: 947
H-index: 16
I10-index: 26
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