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Gerard L. Brien

Degradation of the BAF Complex Factor BRD9 by Heterobifunctional Ligands
2017 · David Remillard, Dennis L. Buckley, et al. · Angewandte Chemie International Edition · 293
Polycomb PHF19 binds H3K36me3 and recruits PRC2 and demethylase NO66 to embryonic stem cell genes during differentiation
2012 · Gerard L Brien, Guillermo Gambero, et al. · Nature Structural & Molecular Biology · 280
Targeted degradation of BRD9 reverses oncogenic gene expression in synovial sarcoma
2018 · Gerard L Brien, David Remillard, et al. · eLife · 225
Dangerous liaisons: interplay between SWI/SNF, NuRD, and Polycomb in chromatin regulation and cancer
2019 · Adrian P. Bracken, Gerard L. Brien, et al. · Genes & Development · 203
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NUP98 Fusion Proteins Interact with the NSL and MLL1 Complexes to Drive Leukemogenesis
2016 · Haiming Xu, Daria G. Valerio, et al. · Cancer Cell · 170
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Exploiting the Epigenome to Control Cancer-Promoting Gene-Expression Programs
2016 · Gerard L. Brien, Daria G. Valerio, et al. · Cancer Cell · 156
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Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells
2016 · Giorgio Oliviero, Gerard L. Brien, et al. · Molecular & Cellular Proteomics · 86
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Targeting chromatin complexes in fusion protein-driven malignancies
2019 · Gerard L. Brien, Kimberly Stegmaier, et al. · Nature reviews. Cancer · 84
Simultaneous disruption of PRC2 and enhancer function underlies histone H3.3-K27M oncogenic activity in human hindbrain neural stem cells
2021 · Gerard L. Brien, Raul Bardini Bressan, et al. · Nature Genetics · 81
Degradation of the BAF Complex Factor BRD9 by Heterobifunctional Ligands
2017 · David Remillard, Dennis L. Buckley, et al. · Angewandte Chemie · 24
Delineating transcriptional networks of prognostic gene signatures refines treatment recommendations for lymph node‐negative breast cancer patients
2015 · Fiona Lanigan, Gerard L. Brien, et al. · FEBS Journal · 18
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A specific form of cPRC1 containing CBX4 is co-opted to mediate oncogenic gene repression in diffuse midline glioma
2025 · Eimear Lagan, Dáire Gannon, et al. · Molecular Cell · 17
A conserved switch to less catalytically active Polycomb repressive complexes in non-dividing cells
2025 · Rachel McCole, James Nolan, et al. · Cell Reports · 15
Transcriptomics: Unravelling the biology of transcription factors and chromatin remodelers during development and differentiation
2009 · Gerard L. Brien, Adrian P. Bracken · Seminars in Cell and Developmental Biology · 10
The PCL1-p53 axis promotes cellular quiescence
2015 · Gerard L. Brien, Adrian P. Bracken · Cell Cycle · 7
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Targeting SUMO2 reverses aberrant epigenetic rewiring driven by SS18::SSX fusion oncoproteins and impairs sarcomagenesis
2025 · Rema Iyer, Anagha Deshpande, et al. · The EMBO Journal · 6
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Author response: Targeted degradation of BRD9 reverses oncogenic gene expression in synovial sarcoma
2018 · Gerard L Brien, David Remillard, et al. · eLife · 6
SS18-SSX co-opts P300 to sustain oncogenic transcription independent of SWI/SNF activity
2026 · Anthony M. Doherty, Eimear Lagan, et al. · bioRxiv (Cold Spring Harbor Laboratory) · 2
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The 3D Genome: EZH2 Comes into the Fold
2019 · Gerard L. Brien, Adrian P. Bracken · Trends in Molecular Medicine · 1
Abstract A28: Targeting PCL3/PHF19 as an alternative therapeutic strategy to EZH2 inhibition in PRC2-deregulated cancers
2013 · Gerard L. Brien, Emilia Jerman, et al. · Cancer Research · 1
SS18-SSX co-opts P300 to sustain oncogenic transcription independent of SWI/SNF activity
2026 · Brien, Gerard · Mendeley Data
AEBP2-Directed H3K27me2 Defines a Specific Vulnerability in EZH2-mutant Lymphoma
2025 · Daniel Angelov, James Nolan, et al. · bioRxiv (Cold Spring Harbor Laboratory)
A Novel Form of AEBP2-Containing PRC2.2 Is a Genetic Dependency in Germinal Centre B-Cell Lymphoma and Its Targeting Can Overcome Acquired Resistance to EZH2 Inhibition
2024 · James Nolan, Daniel Angelov, et al. · Blood
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EZH1-PRC2 Identifies a Potential Reservoir for Disease Relapse in Quiescent Cancer Cells Refractory to EZH2 Enzymatic Inhibition
2022 · Evan Healy, Rachel McCole, et al. · Blood
Canonical PRC1 Recruitment Is Promoted by EZH1-PRC2 Independent of H3K27me3 in Quiescent Cells
2022 · Evan Healy, Rachel McCole, et al. · SSRN Electronic Journal
Works count: 30
Citation count: 1,727
H-index: 14
I10-index: 15
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