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Timothy D. McKee
Observed names:
Timothy D McKee,
Timothy D Mckee,
Timothy D. Mckee,
Timothy McKee
Institutions:
Biogen (United States),
Rodin Therapeutics (United States)
Observed institutions:
Biogen (United States),
Medical University of South Carolina,
Rodin Therapeutics (United States),
Midstate Medical Center,
Meridien Research,
Brandeis University
show all 6
OpenAlex ID:
A5039622004
A General Method for Mapping Tertiary Contacts between Amino Acid Residues in Membrane-Embedded Proteins
1995
·
Hongbo Yu
, Masahiro Kono
, et al.
·
Biochemistry
·
102
Targeted Delivery of DNA Using YEE(GalNAcAH)3, a Synthetic Glycopeptide Ligand for the Asialoglycoprotein Receptor
1994
·
June Rae Merwin
, G. Stephen Noell
, et al.
·
Bioconjugate Chemistry
·
93
Discovery of a Novel Pharmacological and Structural Class of Gamma Secretase Modulators Derived from the Extract of Actaea racemosa
2012
·
Mark A. Findeis
, Frank Schroeder
, et al.
·
ACS Chemical Neuroscience
·
61
CoREST Complex-Selective Histone Deacetylase Inhibitors Show Prosynaptic Effects and an Improved Safety Profile To Enable Treatment of Synaptopathies
2018
·
Nathan O. Fuller
, Antonella Pirone
, et al.
·
ACS Chemical Neuroscience
·
51
Optimization of a Natural Product-Based Class of γ-Secretase Modulators
2012
·
Jed L. Hubbs
, Nathan O. Fuller
, et al.
·
Journal of Medicinal Chemistry
·
46
ATP-Competitive MLKL Binders Have No Functional Impact on Necroptosis
2016
·
Bin Ma
, Doug Marcotte
, et al.
·
PLoS ONE
·
45
PDF
Preparation of Asialoorosomucoid-Polylysine Conjugates
1994
·
Timothy D. McKee
, Mary E. DeRome
, et al.
·
Bioconjugate Chemistry
·
45
An improved rhodopsin/EGFP fusion protein for use in the generation of transgenic Xenopus laevis
2003
·
Shengnan Jin
, Timothy D McKee
, et al.
·
FEBS Letters
·
32
Modulation of Gamma-Secretase for the Treatment of Alzheimer's Disease
2012
·
Barbara Tate
, Timothy D. McKee
, et al.
·
International Journal of Alzheimer s Disease
·
27
PDF
Germinal‐center kinase‐like kinase co‐crystal structure reveals a swapped activation loop and C‐terminal extension
2016
·
Douglas Marcotte
, Mia Rushe
, et al.
·
Protein Science
·
24
PDF
Efficacy of SPI-1865, a novel gamma-secretase modulator, in multiple rodent models
2013
·
Robyn M Loureiro
, Jo Ann Dumin
, et al.
·
Alzheimer s Research & Therapy
·
24
PDF
Initial Optimization of a New Series of γ-Secretase Modulators Derived from a Triterpene Glycoside
2012
·
Nathan O. Fuller
, Jed L. Hubbs
, et al.
·
ACS Medicinal Chemistry Letters
·
23
An improved cell-based method for determining the γ-secretase enzyme activity against both Notch and APP substrates
2012
·
Timothy D. McKee
, Robyn M.B. Loureiro
, et al.
·
Journal of Neuroscience Methods
·
14
SAR investigations on a novel class of gamma-secretase modulators based on a unique scaffold
2013
·
Wesley F. Austin
, Jed L. Hubbs
, et al.
·
MedChemComm
·
10
Natural Product and Natural Product-Derived Gamma Secretase Modulators from Actaea Racemosa Extracts
2015
·
Mark Findeis
, Frank Schroeder
, et al.
·
Medicines
·
9
PDF
Minimization of drug–drug interaction risk and candidate selection in a natural product-based class of gamma-secretase modulators
2015
·
Jed L. Hubbs
, Nathan O. Fuller
, et al.
·
Bioorganic & Medicinal Chemistry Letters
·
9
Investigating small molecules to inhibit germinal center kinase-like kinase (GLK/MAP4K3) upstream of PKCθ phosphorylation: Potential therapy to modulate T cell dependent immunity
2018
·
Tricia L. May-Dracka
, Robert Arduini
, et al.
·
Bioorganic & Medicinal Chemistry Letters
·
5
P2‐095: An improved cell‐based method for determining the gamma‐secretase enzyme activity against both Notch and APP substrates
2012
·
Timothy McKee
, Robyn Loureiro
, et al.
·
Alzheimer s & Dementia
·
2
Engineering a “Steric Doorstop” in Rhodopsin: Converting an Inverse Agonist to an Agonist
2007
·
Timothy D. McKee
, Margaret R. Lewis
, et al.
·
Biochemistry
·
2
O1‐11‐01: Satori gamma‐secretase modulators are efficacious in wild‐type rodents following either acute or steady‐state dosing
2012
·
Robyn Loureiro
, Timothy McKee
, et al.
·
Alzheimer s & Dementia
·
1
P2‐513: Classification of γ‐secretase modulators and their effect on pharmacological profiles of amyloid β peptides
2011
·
Weiming Xia
, Timothy McKee
, et al.
·
Alzheimer s & Dementia
·
1
111. Synaptic Vesicle Glycoprotein 2A (SV2A) Levels as a Translatable Measure of Synaptic Density Following HDAC Inhibition
2018
·
Magnus Ivarsson
, Maria Quinton
, et al.
·
Biological Psychiatry
P4‐199: Pharmacokinetic properties of a Satori gamma‐secretase modulator, SPI‐1865, in multiple animal model systems
2012
·
Brian Bronk
, Timothy McKee
, et al.
·
Alzheimer s & Dementia
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Works count:
25
Citation count:
626
H-index:
13
I10-index:
14
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