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Hans H. Locher

Chimeric peptidomimetic antibiotics against Gram-negative bacteria
2019 · Anatol Luther, Matthias Urfer, et al. · Nature · 305
A single amino acid substitution in Staphylococcus aureus dihydrofolate reductase determines trimethoprim resistance 1 1 Edited by T.Richmond
1997 · Glenn E. Dale, Clemens Broger, et al. · Journal of Molecular Biology · 177
Peptide Deformylase as an Antibacterial Drug Target: Target Validation and Resistance Development
2001 · Christian M. Apfel, Hans Locher, et al. · Antimicrobial Agents and Chemotherapy · 127
Hydroxamic Acid Derivatives as Potent Peptide Deformylase Inhibitors and Antibacterial Agents
2000 · Christian Apfel, David W. Banner, et al. · Journal of Medicinal Chemistry · 112
The Targets of Currently Used Antibacterial Agents: Lessons for Drug Discovery
2007 · Roland Lange, Hans Locher, et al. · Current Pharmaceutical Design · 107
In VitroandIn VivoAntibacterial Evaluation of Cadazolid, a New Antibiotic for Treatment of Clostridium difficile Infections
2013 · Hans H. Locher, Peter Seiler, et al. · Antimicrobial Agents and Chemotherapy · 93
4-Sulphobenzoate 3,4-dioxygenase. Purification and properties of a desulphonative two-component enzyme system from Comamonas testosteroni T-2
1991 · H H Locher, T Leisinger, et al. · Biochemical Journal · 85
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Investigations of the Mode of Action and Resistance Development of Cadazolid, a New Antibiotic for Treatment of Clostridium difficile Infections
2013 · Hans H. Locher, Patrick Caspers, et al. · Antimicrobial Agents and Chemotherapy · 81
Design, Synthesis and Biological Evaluation of Oxazolidinone–Quinolone Hybrids
2003 · Christian Hubschwerlen, Jean-Luc Specklin, et al. · Bioorganic & Medicinal Chemistry · 80
Potent Algicides Based on the Cyanobacterial Alkaloid Nostocarboline
2006 · Judith F. Blom, Tobias Brütsch, et al. · Organic Letters · 79
Novel Dihydrofolate Reductase Inhibitors. Structure-Based versus Diversity-Based Library Design and High-Throughput Synthesis and Screening
2003 · Pierre C. Wyss, Paul Gerber, et al. · Journal of Medicinal Chemistry · 71
Design, Synthesis, and Characterization of Novel Tetrahydropyran-Based Bacterial Topoisomerase Inhibitors with Potent Anti-Gram-Positive Activity
2013 · Jean-Philippe Surivet, Cornelia Zumbrunn, et al. · Journal of Medicinal Chemistry · 69
In vitro activity of cadazolid against clinically relevant Clostridium difficile isolates and in an in vitro gut model of C. difficile infection
2013 · C. H. Chilton, G. S. Crowther, et al. · Journal of Antimicrobial Chemotherapy · 66
Biomimetic Total Synthesis and Antimicrobial Evaluation of Anachelin H
2007 · Karl Gademann, Yann Bethuel, et al. · The Journal of Organic Chemistry · 54
Structure–activity relationship in the oxazolidinone–quinolone hybrid series: influence of the central spacer on the antibacterial activity and the mode of action
2003 · Christian Hubschwerlen, Jean-Luc Specklin, et al. · Bioorganic & Medicinal Chemistry Letters · 54
Antibacterial activities of epiroprim, a new dihydrofolate reductase inhibitor, alone and in combination with dapsone
1996 · H H Locher, H Schlunegger, et al. · Antimicrobial Agents and Chemotherapy · 53
Peptidomimetic antibiotics disrupt the lipopolysaccharide transport bridge of drug-resistant Enterobacteriaceae
2023 · Matthias Schuster, Emile Brabet, et al. · Science Advances · 52
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4-Toluene sulfonate methyl-monooxygenase from Comamonas testosteroni T-2: purification and some properties of the oxygenase component
1991 · H H Locher, T Leisinger, et al. · Journal of Bacteriology · 52
Degradation of p-Toluenesulphonic Acid via Sidechain Oxidation, Desulphonation and meta Ring Cleavage in Pseudomonas (Comamonas) testosteroni T-2
1989 · H. H. Locher, T. Leisinger, et al. · Microbiology · 51
Uptake of 4-toluene sulfonate by Comamonas testosteroni T-2
1993 · H H Locher, B Poolman, et al. · Journal of Bacteriology · 48
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2-(2-Oxo-1,4-dihydro-2H-quinazolin-3-yl)- and 2-(2,2-Dioxo-1,4-dihydro-2H-2λ6-benzo[1,2,6]thiadiazin-3-yl)-N-hydroxy-acetamides as Potent and Selective Peptide Deformylase Inhibitors
2001 · Christian Apfel, David W. Banner, et al. · Journal of Medicinal Chemistry · 40
Synthesis and Characterization of Tetrahydropyran-Based Bacterial Topoisomerase Inhibitors with Antibacterial Activity against Gram-Negative Bacteria
2017 · Jean-Philippe Surivet, Cornelia Zumbrunn, et al. · Journal of Medicinal Chemistry · 39
Novel Tetrahydropyran-Based Bacterial Topoisomerase Inhibitors with Potent Anti-Gram Positive Activity and Improved Safety Profile
2014 · Jean-Philippe Surivet, Cornelia Zumbrunn, et al. · Journal of Medicinal Chemistry · 35
Structure-guided design, synthesis and biological evaluation of novel DNA ligase inhibitors with in vitro and in vivo anti-staphylococcal activity
2012 · Jean-Philippe Surivet, Roland Lange, et al. · Bioorganic & Medicinal Chemistry Letters · 35
3-Nitrobenzenesulfonate, 3-Aminobenzenesulfonate, and 4-Aminobenzenesulfonate as Sole Carbon Sources for Bacteria
1989 · Hans H. Locher, Thomas Thurnheer, et al. · Applied and Environmental Microbiology · 35
Works count: 45
Citation count: 2,196
H-index: 26
I10-index: 35
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