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Ulrich F. Heiser

Glutaminyl cyclase inhibition attenuates pyroglutamate Aβ and Alzheimer's disease–like pathology
2008 · Stephan Schilling, Ulrike Zeitschel, et al. · Nature Medicine · 360
The crystal structure of dipeptidyl peptidase IV (CD26) reveals its functional regulation and enzymatic mechanism
2003 · Michael Engel, Torsten Hoffmann, et al. · Proceedings of the National Academy of Sciences · 313
The First Potent Inhibitors for Human Glutaminyl Cyclase: Synthesis and Structure−Activity Relationship
2005 · Mirko Buchholz, Ulrich Heiser, et al. · Journal of Medicinal Chemistry · 107
Temperature-Dependent Behavior of a Symmetric Long-Chain Bolaamphiphile with Phosphocholine Headgroups in Water: From Hydrogel to Nanoparticles
2004 · Karen Köhler, Günter Förster, et al. · Journal of the American Chemical Society · 107
Modulation of inositol 1,4,5‐triphosphate concentration by prolyl endopeptidase inhibition
2002 · Ingo Schulz, Bernd Gerhartz, et al. · European Journal of Biochemistry · 98
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The isoenzyme of glutaminyl cyclase is an important regulator of monocyte infiltration under inflammatory conditions
2011 · Holger Cynis, Torsten Hoffmann, et al. · EMBO Molecular Medicine · 97
Neuropeptide Y (NPY) cleaving enzymes: Structural and functional homologues of dipeptidyl peptidase 4
2007 · Nadine Frerker, Leona Wagner, et al. · Peptides · 93
Inhibition of glutaminyl cyclase alters pyroglutamate formation in mammalian cells
2006 · Holger Cynis, Stephan Schilling, et al. · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · 87
Effects of dipeptidyl peptidase IV on the satiety actions of peptide YY
2006 · S. Unniappan, C. H. S. McIntosh, et al. · Diabetologia · 83
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Glutaminyl Cyclase Inhibitor PQ912 Improves Cognition in Mouse Models of Alzheimer’s Disease—Studies on Relation to Effective Target Occupancy
2017 · Torsten Hoffmann, Antje Meyer, et al. · Journal of Pharmacology and Experimental Therapeutics · 78
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Inhibition of glutaminyl cyclase prevents pGlu‐Aβ formation after intracortical/hippocampal microinjection in vivo/in situ
2008 · Stephan Schilling, Thomas Appl, et al. · Journal of Neurochemistry · 77
Self‐Assembly in a Bipolar Phosphocholine–Water System: The Formation of Nanofibers and Hydrogels
2003 · Karen Köhler, Günter Förster, et al. · Angewandte Chemie International Edition · 74
Structure–Activity Relationships of Benzimidazole-Based Glutaminyl Cyclase Inhibitors Featuring a Heteroaryl Scaffold
2013 · Daniel Ramsbeck, Mirko Buchholz, et al. · Journal of Medicinal Chemistry · 71
Metabolism of glucagon by dipeptidyl peptidase IV (CD26)
2001 · John A Pospisilik, Simon A Hinke, et al. · Regulatory Peptides · 70
Inhibitors for Human Glutaminyl Cyclase by Structure Based Design and Bioisosteric Replacement
2009 · Mirko Buchholz, Antje Hamann, et al. · Journal of Medicinal Chemistry · 69
Rigidity and Flexibility of Dipeptidyl Peptidase IV: Crystal Structures of and Docking Experiments with DPIV
2005 · Michael Engel, Torsten Hoffmann, et al. · Journal of Molecular Biology · 67
A phase 1 study to evaluate the safety and pharmacokinetics of PQ912, a glutaminyl cyclase inhibitor, in healthy subjects
2015 · Inge Lues, Frank Weber, et al. · Alzheimer s & Dementia Translational Research & Clinical Interventions · 62
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Continuous Spectrometric Assays for Glutaminyl Cyclase Activity
2002 · Stephan Schilling, Torsten Hoffmann, et al. · Analytical Biochemistry · 55
Inhibition of CDK9 as a therapeutic strategy for inflammatory arthritis
2016 · Annelie Hellvard, Lutz Zeitlmann, et al. · Scientific Reports · 38
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Identifying neuropeptide Y (NPY) as the main stress-related substrate of dipeptidyl peptidase 4 (DPP4) in blood circulation
2016 · Leona Wagner, Florian Kaestner, et al. · Neuropeptides · 38
Inhibition of Glutaminyl Cyclases alleviates CCL 2‐mediated inflammation of non‐alcoholic fatty liver disease in mice
2013 · Holger Cynis, Astrid Kehlen, et al. · International Journal of Experimental Pathology · 38
Inhibition of Mammalian Legumain by Michael Acceptors and AzaAsn-Halomethylketones
2002 · A. J. Niestroj, K. Feußner, et al. · Biological Chemistry · 36
Isolation, Catalytic Properties, and Competitive Inhibitors of the Zinc-Dependent Murine Glutaminyl Cyclase
2005 · Stephan Schilling, Holger Cynis, et al. · Biochemistry · 34
Structures of Glycosylated Mammalian Glutaminyl Cyclases Reveal Conformational Variability near the Active Center
2011 · David Ruiz-Carrillo, Birgit Koch, et al. · Biochemistry · 30
Glutaminyl Cyclases as Novel Targets for the Treatment of Septic Arthritis
2012 · Annelie Hellvard, Katarzyna Maresz, et al. · The Journal of Infectious Diseases · 21
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Works count: 47
Citation count: 2,332
H-index: 24
I10-index: 33
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