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Asfandyar Sikandar

The natural product carolacton inhibits folate-dependent C1 metabolism by targeting FolD/MTHFD
2017 · Chengzhang Fu, Asfandyar Sikandar, et al. · Nature Communications · 86
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Thioholgamides: Thioamide-Containing Cytotoxic RiPP Natural Products
2017 · Louise Kjaerulff, Asfandyar Sikandar, et al. · ACS Chemical Biology · 79
Tutuilamides A–C: Vinyl-Chloride-Containing Cyclodepsipeptides from Marine Cyanobacteria with Potent Elastase Inhibitory Properties
2020 · Lena Keller, Kirley Marques Canuto, et al. · ACS Chemical Biology · 58
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Binding Mode Characterization and Early in Vivo Evaluation of Fragment-Like Thiols as Inhibitors of the Virulence Factor LasB from Pseudomonas aeruginosa
2018 · Andreas M. Kany, Asfandyar Sikandar, et al. · ACS Infectious Diseases · 43
Tackling Pseudomonas aeruginosa Virulence by a Hydroxamic Acid-Based LasB Inhibitor
2018 · Andreas M. Kany, Asfandyar Sikandar, et al. · ACS Chemical Biology · 40
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Total In Vitro Biosynthesis of the Thioamitide Thioholgamide and Investigation of the Pathway
2022 · Asfandyar Sikandar, Maria Lopatniuk, et al. · Journal of the American Chemical Society · 38
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Inhibitors of the Elastase LasB for the Treatment of Pseudomonas aeruginosa Lung Infections
2023 · Jelena Konstantinović, Andreas M. Kany, et al. · ACS Central Science · 36
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Adaptation of a Bacterial Multidrug Resistance System Revealed by the Structure and Function of AlbA
2018 · Asfandyar Sikandar, Katarina Cirnski, et al. · Journal of the American Chemical Society · 26
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Structure-Based Design of α-Substituted Mercaptoacetamides as Inhibitors of the Virulence Factor LasB from Pseudomonas aeruginosa
2022 · Cansu Kaya, Isabell Walter, et al. · ACS Infectious Diseases · 24
The bottromycin epimerase BotH defines a group of atypical α/β-hydrolase-fold enzymes
2020 · Asfandyar Sikandar, Laura Franz, et al. · Nature Chemical Biology · 24
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The role of protein–protein interactions in the biosynthesis of ribosomally synthesized and post-translationally modified peptides
2019 · Asfandyar Sikandar, Jesko Koehnke · Natural Product Reports · 23
Substrate‐Inspired Fragment Merging and Growing Affords Efficacious LasB Inhibitors
2021 · Cansu Kaya, Isabell Walter, et al. · Angewandte Chemie International Edition · 22
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Thiazoline-Specific Amidohydrolase PurAH Is the Gatekeeper of Bottromycin Biosynthesis
2019 · Asfandyar Sikandar, Laura Franz, et al. · Journal of the American Chemical Society · 21
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Photorhabdus luminescens lectin A (PllA): A new probe for detecting α-galactoside–terminating glycoconjugates
2017 · Ghamdan Beshr, Asfandyar Sikandar, et al. · Journal of Biological Chemistry · 17
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Dipeptidic Phosphonates: Potent Inhibitors of Pseudomonas aeruginosa Elastase B Showing Efficacy in a Murine Keratitis Model
2025 · Alexander F. Kiefer, Christian Schütz, et al. · Advanced Science · 14
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Revision of the Absolute Configurations of Chelocardin and Amidochelocardin
2023 · Asfandyar Sikandar, Alexander Popoff, et al. · Angewandte Chemie International Edition · 11
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Non-Heme Monooxygenase ThoJ Catalyzes Thioholgamide β-Hydroxylation
2020 · Asfandyar Sikandar, Maria Lopatniuk, et al. · ACS Chemical Biology · 11
Myxarylin: Total In Vitro Biosynthesis, Expansion of Substrate Scope, and Bioengineered Thioamidated Biarylitides
2026 · Asfandyar Sikandar, Lana Vianey, et al. · Journal of the American Chemical Society · 9
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N-Aryl-2-iso-butylmercaptoacetamides: the discovery of highly potent and selective inhibitors of Pseudomonas aeruginosa virulence factor LasB and Clostridium histolyticum virulence factor ColH
2022 · Katrin Voos, Samir Yahiaoui, et al. · ChemRxiv · 7
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Tandem ketone reduction in pepstatin biosynthesis reveals an F420H2–dependent statine pathway
2025 · Jingjun Mo, Asfandyar Sikandar, et al. · Nature Communications · 6
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A fucose-binding superlectin from Enterobacter cloacae with high Lewis and ABO blood group antigen specificity
2024 · Ghamdan Beshr, Asfandyar Sikandar, et al. · Journal of Biological Chemistry · 3
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Atypical Condensation Domains Guide Discovery and Illuminate Biosynthesis of Myxoglucamides Featuring Vinyl‐Substituted, α‐Oxidized γ‐Amino Acids
2026 · Tingting Wang, Alexander Popoff, et al. · Angewandte Chemie International Edition · 2
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Structural Studies of Human Norovirus Protease Complexes with RNA and Peptides
2015 · Sikandar, Asfandyar · Libraries and Cultural Resources (University of Calgary) · 1
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Kinetic Target-Guided Discovery of Selective Nanomolar Hydroxamic Acid–Based Inhibitors of Pseudomonas aeruginosa Elastase LasB
2026 · Virgyl Camberlein, Angeliki Vgenopoulou, et al. · ChemRxiv
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Hidden Diversity in Myxobacterial Lasso Peptides: An Atypical RiPP Recognition Element and Host-Mediated Loss of the Lasso Tail
2026 · Asfandyar Sikandar, Haowen Zhao, et al. · ChemRxiv
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Works count: 63
Citation count: 601
H-index: 14
I10-index: 17
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