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Ignacio Moraleda

Observed name: Moraleda, Ignacio
ORCID: 0000-0001-8032-5689
Observed ORCID: 0000-0001-8032-5689
OpenAlex ID: A5041836281
Design, synthesis, pharmacological evaluation, QSAR analysis, molecular modeling and ADMET of novel donepezil–indolyl hybrids as multipotent cholinesterase/monoamine oxidase inhibitors for the potential treatment of Alzheimer's disease
2014 · Oscar M. Bautista-Aguilera, Gerard Esteban, et al. · European Journal of Medicinal Chemistry · 147
Donepezil + propargylamine + 8-hydroxyquinoline hybrids as new multifunctional metal-chelators, ChE and MAO inhibitors for the potential treatment of Alzheimer's disease
2014 · Li Wang, Gerard Esteban, et al. · European Journal of Medicinal Chemistry · 145
Tackling neuroinflammation and cholinergic deficit in Alzheimer's disease: Multi-target inhibitors of cholinesterases, cyclooxygenase-2 and 15-lipoxygenase
2019 · Ehab D. AlFadly, Perihan A. Elzahhar, et al. · European Journal of Medicinal Chemistry · 111
Multitarget‐Directed Ligands Combining Cholinesterase and Monoamine Oxidase Inhibition with Histamine H3R Antagonism for Neurodegenerative Diseases
2017 · Óscar M. Bautista‐Aguilera, Stefanie Hagenow, et al. · Angewandte Chemie International Edition · 105
Flecainide increases Kir2.1 currents by interacting with cysteine 311, decreasing the polyamine-induced rectification
2010 · Ricardo Caballero, Pablo Dolz-Gaitón, et al. · Proceedings of the National Academy of Sciences · 89
Synthesis, Inhibitory Activity of Cholinesterases, and Neuroprotective Profile of Novel 1,8-Naphthyridine Derivatives
2010 · Cristóbal de los Ríos, Javier Egea, et al. · Journal of Medicinal Chemistry · 79
Multipotent MAO and cholinesterase inhibitors for the treatment of Alzheimer's disease: Synthesis, pharmacological analysis and molecular modeling of heterocyclic substituted alkyl and cycloalkyl propargyl amine
2012 · Abdelouahid Samadi, Cristóbal de los Ríos, et al. · European Journal of Medicinal Chemistry · 73
Synthesis, biological assessment and molecular modeling of new multipotent MAO and cholinesterase inhibitors as potential drugs for the treatment of Alzheimer’s disease
2011 · Abdelouahid Samadi, Mourad Chioua, et al. · European Journal of Medicinal Chemistry · 71
Synthesis, biological assessment, and molecular modeling of racemic 7-aryl-9,10,11,12-tetrahydro-7H-benzo[7,8]chromeno[2,3-b]quinolin-8-amines as potential drugs for the treatment of Alzheimer's disease
2012 · Emna Maalej, Fakher Chabchoub, et al. · European Journal of Medicinal Chemistry · 69
Harmaline and hispidin from Peganum harmala and Inonotus hispidus with binding affinity to Candida rugosa lipase: In silico and in vitro studies
2015 · Khedidja Benarous, Isabelle Bombarda, et al. · Bioorganic Chemistry · 67
Pyridonepezils, new dual AChE inhibitors as potential drugs for the treatment of Alzheimer's disease: Synthesis, biological assessment, and molecular modeling
2012 · Abdelouahid Samadi, Martín Estrada, et al. · European Journal of Medicinal Chemistry · 66
Contilisant, a Tetratarget Small Molecule for Alzheimer’s Disease Therapy Combining Cholinesterase, Monoamine Oxidase Inhibition, and H3R Antagonism with S1R Agonism Profile
2018 · Óscar M. Bautista-Aguilera, Josiane Budni, et al. · Journal of Medicinal Chemistry · 64
Multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of Alzheimer’s disease: design, synthesis, biochemical evaluation, ADMET, molecular modeling, and QSAR analysis of novel donepezil-pyridyl hybrids
2014 · José Marco-Contelles, Oscar Bautista-Aguilera, et al. · Drug Design Development and Therapy · 61
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Donepezil + chromone + melatonin hybrids as promising agents for Alzheimer’s disease therapy
2019 · Irene Pachón-Angona, Bernard Refouvelet, et al. · Journal of Enzyme Inhibition and Medicinal Chemistry · 60
Discovery of novel benzofuran-based compounds with neuroprotective and immunomodulatory properties for Alzheimer's disease treatment
2019 · Serena Montanari, Ali Mokhtar Mahmoud, et al. · European Journal of Medicinal Chemistry · 53
Synthesis, Pharmacological Assessment, and Molecular Modeling of Acetylcholinesterase/Butyrylcholinesterase Inhibitors: Effect against Amyloid-β-Induced Neurotoxicity
2013 · Daniel Silva, Mourad Chioua, et al. · ACS Chemical Neuroscience · 53
Potent anticholinesterasic and neuroprotective pyranotacrines as inhibitors of beta-amyloid aggregation, oxidative stress and tau-phosphorylation for Alzheimer's disease
2016 · Nuria García-Font, Hasna Hayour, et al. · European Journal of Medicinal Chemistry · 52
Synthesis and biological assessment of diversely substituted furo[2,3-b]quinolin-4-amine and pyrrolo[2,3-b]quinolin-4-amine derivatives, as novel tacrine analogues
2011 · Carla Martins, M. Carmo Carreiras, et al. · European Journal of Medicinal Chemistry · 51
Tacripyrimidines, the first tacrine-dihydropyrimidine hybrids, as multi-target-directed ligands for Alzheimer's disease
2018 · Mourad Chioua, Eleonora Buzzi, et al. · European Journal of Medicinal Chemistry · 50
New Dual Small Molecules for Alzheimer’s Disease Therapy Combining Histamine H 3 Receptor (H3R) Antagonism and Calcium Channels Blockade with Additional Cholinesterase Inhibition
2019 · Rim Malek, Raquel L. Arribas, et al. · Journal of Medicinal Chemistry · 44
Tetrahydropyranodiquinolin-8-amines as new, non hepatotoxic, antioxidant, and acetylcholinesterase inhibitors for Alzheimer's disease therapy
2016 · Youssef Dgachi, Olga Sokolov, et al. · European Journal of Medicinal Chemistry · 42
Synthesis, pharmacological assessment, and molecular modeling of 6-chloro-pyridonepezils: New dual AChE inhibitors as potential drugs for the treatment of Alzheimer's disease
2013 · Abdelouahid Samadi, Mario de la Fuente Revenga, et al. · European Journal of Medicinal Chemistry · 39
Multi-target 1,4-dihydropyridines showing calcium channel blockade and antioxidant capacity for Alzheimer’s disease therapy
2019 · Rim Malek, Maciej Maj, et al. · Bioorganic Chemistry · 38
Exploiting the Chalcone Scaffold to Develop Multifunctional Agents for Alzheimer’s Disease
2018 · Angela Rampa, Manuela Bartolini, et al. · Molecules · 31
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Dendrimer-functionalized electrospun nanofibres as dual-action water treatment membranes
2017 · Georgiana Amariei, Javier Santiago-Morales, et al. · The Science of The Total Environment · 31
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Works count: 41
Citation count: 1,907
H-index: 26
I10-index: 37
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