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Kyle E. Parcella
Observed names:
Kyle Parcella,
Parcella, Kyle
Institutions:
ViiV Healthcare (Spain),
ViiV Healthcare (United Kingdom)
Observed institutions:
ViiV Healthcare (Spain),
Bristol-Myers Squibb (United States),
ViiV Healthcare (United Kingdom),
Connecticut College
ORCID:
0000-0003-0852-344X
Observed ORCID:
0000-0003-0852-344X
OpenAlex ID:
A5042769313
Discovery of a Hepatitis C Virus NS5B Replicase Palm Site Allosteric Inhibitor (BMS-929075) Advanced to Phase 1 Clinical Studies
2017
·
Kap-Sun Yeung
, Brett R. Beno
, et al.
·
Journal of Medicinal Chemistry
·
33
Improving Metabolic Stability with Deuterium: The Discovery of BMT-052, a Pan-genotypic HCV NS5B Polymerase Inhibitor
2017
·
Kyle Parcella
, Kyle Eastman
, et al.
·
ACS Medicinal Chemistry Letters
·
28
The discovery of a pan-genotypic, primer grip inhibitor of HCV NS5B polymerase
2017
·
Kyle J. Eastman
, Kyle Parcella
, et al.
·
MedChemComm
·
19
PDF
Antiviral Properties of HIV-1 Capsid Inhibitor GSK878
2023
·
Chunfu Wang
, Haichang Huang
, et al.
·
Antimicrobial Agents and Chemotherapy
·
13
PDF
Discovery and Preclinical Profiling of GSK3839919, a Potent HIV-1 Allosteric Integrase Inhibitor
2022
·
Kyle Parcella
, Tao Wang
, et al.
·
ACS Medicinal Chemistry Letters
·
12
Bioactivation of cyclopropyl rings by P450: an observation encountered during the optimisation of a series of hepatitis C virus NS5B inhibitors
2017
·
Xiaoliang Zhuo
, Ying-Zi Wang
, et al.
·
Xenobiotica
·
11
The HIV-1 Capsid-Targeted Inhibitor GSK878 Alters Selection of Target Sites for HIV DNA Integration
2023
·
Kaitlin A. Marquis
, John Everett
, et al.
·
AIDS Research and Human Retroviruses
·
8
PDF
Scaffold modifications to the 4-(4,4-dimethylpiperidinyl) 2,6-dimethylpyridinyl class of HIV-1 allosteric integrase inhibitors
2022
·
Kyle Parcella
, Manoj Patel
, et al.
·
Bioorganic & Medicinal Chemistry
·
8
Discovery and initial optimization of alkoxyanthranilic acid derivatives as inhibitors of HCV NS5B polymerase
2016
·
Kyle Parcella
, Andrew Nickel
, et al.
·
Bioorganic & Medicinal Chemistry Letters
·
7
PDF
Structure–Property Basis for Solving Transporter-Mediated Efflux and Pan-Genotypic Inhibition in HCV NS5B Inhibitors
2018
·
Kap-Sun Yeung
, Brett R. Beno
, et al.
·
ACS Medicinal Chemistry Letters
·
6
Phosphocholine Conjugation: An Unexpected In Vivo Conjugation Pathway Associated with Hepatitis C NS5B Inhibitors Featuring A Bicyclo[1.1.1]Pentane
2016
·
Xiaoliang Zhuo
, Joseph L. Cantone
, et al.
·
Drug Metabolism and Disposition
·
6
Preclinical virology profiles of the HIV-1 capsid inhibitors VH4004280 and VH4011499
2025
·
Chunfu Wang
, Haichang Huang
, et al.
·
Antimicrobial Agents and Chemotherapy
·
5
Kinetics of the thermal isomerization of 1,1,2,2‐tetramethylcyclopropane
2006
·
David K. Lewis
, Timothy Gray
, et al.
·
International Journal of Chemical Kinetics
·
4
CCDC 1541557: Experimental Crystal Structure Determination
2017
·
Yeung, Kap-Sun
, Beno, Brett R.
, et al.
·
The Cambridge Structural Database
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Works count:
14
Citation count:
160
H-index:
8
I10-index:
6
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