Author

Eduardo Howard

Observed names: E. Howard, E. I. HOWARD, E. I. Howard, E.I. Howard, Eduardo I. Howard, Howard, E. I., Howard, E.I., Howard, Eduardo I., Howard, Eduardo Ignacio

Institution: National Technological University

Observed institutions: National Technological University, Hauptman-Woodward Medical Research Institute, Centre National de la Recherche Scientifique, Consejo Nacional de Investigaciones Científicas y Técnicas, Inserm, Universidad de Granada, The Netherlands Cancer Institute, Institut de génétique et de biologie moléculaire et cellulaire, Instituto Andaluz de Ciencias de la Tierra, Instituto de Física La Plata, Instituto de Fisica de Liquidos y Sistemas Biologicos, Université Henri Poincaré, École Polytechnique Fédérale de Lausanne, Université de Strasbourg, Universidad Nacional de La Plata

ORCID: 0000-0002-5810-2128

Observed ORCID: 0000-0002-5810-2128

OpenAlex ID: A5043598828

Ultrahigh resolution drug design I: Details of interactions in human aldose reductase–inhibitor complex at 0.66 Å

2004 · E.I. Howard, R. Sanishvili, et al. · Proteins Structure Function and Bioinformatics · 327

Interaction of water with α,α-trehalose in solution: molecular dynamics simulation approach

1994 · Maria C. Donnamaria, Eduardo I. Howard, et al. · Journal of the Chemical Society Faraday Transactions · 125

Electrostatic complementarity in an aldose reductase complex from ultra-high-resolution crystallography and first-principles calculations

2003 · Nicolas Muzet, Benoît Guillot, et al. · Proceedings of the National Academy of Sciences · 113

Binding of aldose reductase inhibitors: correlation of crystallographic and mass spectrometric studies

1999 · H. Rogniaux, A. Van Dorsselaer, et al. · Journal of the American Society for Mass Spectrometry · 101

Discovery of (R)-2-Amino-6-borono-2-(2-(piperidin-1-yl)ethyl)hexanoic Acid and Congeners As Highly Potent Inhibitors of Human Arginases I and II for Treatment of Myocardial Reperfusion Injury

2013 · Michael C. Van Zandt, Darren L. Whitehouse, et al. · Journal of Medicinal Chemistry · 94

Neutron macromolecular crystallography with LADI-III

2010 · Matthew P. Blakeley, Susana C. M. Teixeira, et al. · Acta Crystallographica Section D Biological Crystallography · 87

The effect of stereochemistry upon carbohydrate hydration. A molecular dynamics simulation of β-d-galactopyranose and (α,β)-d-talopyranose

1994 · Saskia A. Galema, Eduardo Howard, et al. · Carbohydrate Research · 80

Neutron structure of type‐III antifreeze protein allows the reconstruction of AFP–ice interface

2011 · Eduardo I. Howard, Matthew P. Blakeley, et al. · Journal of Molecular Recognition · 75

Structural Basis of Outstanding Multivalent Effects in Jack Bean α‐Mannosidase Inhibition

2018 · Eduardo Howard, Alexandra Cousido‐Siah, et al. · Angewandte Chemie International Edition · 61

Design and synthesis of highly potent and selective (2-arylcarbamoyl-phenoxy)-acetic acid inhibitors of aldose reductase for treatment of chronic diabetic complications

2004 · Michael C. Van Zandt, Evelyn O. Sibley, et al. · Bioorganic & Medicinal Chemistry · 48

Discovery of N-Substituted 3-Amino-4-(3-boronopropyl)pyrrolidine-3-carboxylic Acids as Highly Potent Third-Generation Inhibitors of Human Arginase I and II

2019 · Michael C. Van Zandt, G. Erik Jagdmann, et al. · Journal of Medicinal Chemistry · 42

Post-translational modifications in DNA topoisomerase 2α highlight the role of a eukaryote-specific residue in the ATPase domain

2018 · Claire Bedez, Christophe Lotz, et al. · Scientific Reports · 42

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High-resolution neutron and X-ray diffraction room-temperature studies of an H-FABP–oleic acid complex: study of the internal water cluster and ligand binding by a transferred multipolar electron-density distribution

2016 · E. I. Howard, B. Guillot, et al. · IUCrJ · 39

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The structure of human aldose reductase bound to the inhibitor IDD384

2000 · Vito Calderone, Bernard Chevrier, et al. · Acta Crystallographica Section D Biological Crystallography · 36

Production of crystals of human aldose reductase with very high resolution diffraction

1999 · V. Lamour, P. Barth, et al. · Acta Crystallographica Section D Biological Crystallography · 31

New insights into the enzymatic mechanism of human chitotriosidase (CHIT1) catalytic domain by atomic resolution X-ray diffraction and hybrid QM/MM

2015 · Firas Fadel, Yuguang Zhao, et al. · Acta Crystallographica Section D Biological Crystallography · 30

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Structure and Interactions of Fish Type III Antifreeze Protein in Solution

2010 · Andrés G. Salvay, Frank Gabel, et al. · Biophysical Journal · 26

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Perdeuteration: improved visualization of solvent structure in neutron macromolecular crystallography

2014 · S. J. Fisher, M. P. Blakeley, et al. · Acta Crystallographica Section D Biological Crystallography · 23

Conformations of erythritol and L-threitol in aqueous solution in relation to sweetness properties: a molecular dynamics simulation

1992 · Eduardo Howard, J. Raul Grigera · Journal of the Chemical Society Faraday Transactions · 21

Perdeuteration, purification, crystallization and preliminary neutron diffraction of an ocean pout type III antifreeze protein

2009 · Isabelle Petit-Haertlein, Matthew P. Blakeley, et al. · Acta Crystallographica Section F Structural Biology and Crystallization Communications · 20

A multicopy modeling of the water distribution in macromolecular crystals

1997 · Alberto D. Podjarny, Eduardo I. Howard, et al. · Proteins Structure Function and Bioinformatics · 20

Model of the catalytic mechanism of human aldose reductase based on quantum chemical calculations

2000 · R. Cachau, E. Howard, et al. · Journal de Physique IV (Proceedings) · 18

Crystal packing modifies ligand binding affinity: The case of aldose reductase

2012 · Alexandra Cousido‐Siah, Tatiana Petrova, et al. · Proteins Structure Function and Bioinformatics · 15

Structural variability of E. coli thioredoxin captured in the crystal structures of single-point mutants

2017 · Martín E. Noguera, Diego S. Vazquez, et al. · Scientific Reports · 14

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Electro-Optical Properties Characterization of Fish Type III Antifreeze Protein

2007 · Andrés G. Salvay, Javier Santos, et al. · Journal of Biological Physics · 14

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