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Mourad Chioua

Synthesis, Biological Evaluation, and Molecular Modeling of Donepezil and N-[(5-(Benzyloxy)-1-methyl-1H-indol-2-yl)methyl]-N-methylprop-2-yn-1-amine Hybrids as New Multipotent Cholinesterase/Monoamine Oxidase Inhibitors for the Treatment of Alzheimer’s Disease
2011 · Irene Bolea, Jordi Juárez-Jiménez, et al. · Journal of Medicinal Chemistry · 224
Multitarget‐Directed Ligands Combining Cholinesterase and Monoamine Oxidase Inhibition with Histamine H3R Antagonism for Neurodegenerative Diseases
2017 · Óscar M. Bautista‐Aguilera, Stefanie Hagenow, et al. · Angewandte Chemie International Edition · 105
Synthesis and biological evaluation of 3,6-diamino-1H-pyrazolo[3,4-b]pyridine derivatives as protein kinase inhibitors
2009 · Mourad Chioua, Abdelouahid Samadi, et al. · Bioorganic & Medicinal Chemistry Letters · 98
Multipotent MAO and cholinesterase inhibitors for the treatment of Alzheimer's disease: Synthesis, pharmacological analysis and molecular modeling of heterocyclic substituted alkyl and cycloalkyl propargyl amine
2012 · Abdelouahid Samadi, Cristóbal de los Ríos, et al. · European Journal of Medicinal Chemistry · 73
α-Aryl-N-alkyl Nitrones, as Potential Agents for Stroke Treatment: Synthesis, Theoretical Calculations, Antioxidant, Anti-inflammatory, Neuroprotective, and Brain–Blood Barrier Permeability Properties
2011 · Mourad Chioua, David Sucunza, et al. · Journal of Medicinal Chemistry · 73
Synthesis, biological assessment and molecular modeling of new multipotent MAO and cholinesterase inhibitors as potential drugs for the treatment of Alzheimer’s disease
2011 · Abdelouahid Samadi, Mourad Chioua, et al. · European Journal of Medicinal Chemistry · 71
N-Methyl-N-((1-methyl-5-(3-(1-(2-methylbenzyl)piperidin-4-yl)propoxy)-1H-indol-2-yl)methyl)prop-2-yn-1-amine, a New Cholinesterase and Monoamine Oxidase Dual Inhibitor
2014 · Oscar M. Bautista-Aguilera, Abdelouahid Samadi, et al. · Journal of Medicinal Chemistry · 69
Synthesis, biological assessment, and molecular modeling of racemic 7-aryl-9,10,11,12-tetrahydro-7H-benzo[7,8]chromeno[2,3-b]quinolin-8-amines as potential drugs for the treatment of Alzheimer's disease
2012 · Emna Maalej, Fakher Chabchoub, et al. · European Journal of Medicinal Chemistry · 69
Pyridonepezils, new dual AChE inhibitors as potential drugs for the treatment of Alzheimer's disease: Synthesis, biological assessment, and molecular modeling
2012 · Abdelouahid Samadi, Martín Estrada, et al. · European Journal of Medicinal Chemistry · 66
Synthesis and pharmacological assessment of diversely substituted pyrazolo[3,4-b]quinoline, and benzo[b]pyrazolo[4,3-g][1,8]naphthyridine derivatives
2011 · Daniel Silva, Mourad Chioua, et al. · European Journal of Medicinal Chemistry · 62
Multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of Alzheimer’s disease: design, synthesis, biochemical evaluation, ADMET, molecular modeling, and QSAR analysis of novel donepezil-pyridyl hybrids
2014 · José Marco-Contelles, Oscar Bautista-Aguilera, et al. · Drug Design Development and Therapy · 61
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Multipotent drugs with cholinergic and neuroprotective properties for the treatment of Alzheimer and neuronal vascular diseases. I. Synthesis, biological assessment, and molecular modeling of simple and readily available 2-aminopyridine-, and 2-chloropyridine-3,5-dicarbonitriles
2010 · Abdelouahid Samadi, José Marco-Contelles, et al. · Bioorganic & Medicinal Chemistry · 59
Toxicological and pharmacological evaluation, antioxidant, ADMET and molecular modeling of selected racemic chromenotacrines {11-amino-12-aryl-8,9,10,12-tetrahydro-7H-chromeno[2,3-b]quinolin-3-ols} for the potential prevention and treatment of Alzheimer's disease
2014 · María Jesús Oset-Gasque, María Pilar González, et al. · European Journal of Medicinal Chemistry · 55
Synthesis, Analytical Features, and Biological Relevance of 5-(3′,4′-Dihydroxyphenyl)-γ-valerolactone, a Microbial Metabolite Derived from the Catabolism of Dietary Flavan-3-ols
2011 · Fernando Sánchez-Patán, Mourad Chioua, et al. · Journal of Agricultural and Food Chemistry · 55
Synthesis, Pharmacological Assessment, and Molecular Modeling of Acetylcholinesterase/Butyrylcholinesterase Inhibitors: Effect against Amyloid-β-Induced Neurotoxicity
2013 · Daniel Silva, Mourad Chioua, et al. · ACS Chemical Neuroscience · 53
Potent anticholinesterasic and neuroprotective pyranotacrines as inhibitors of beta-amyloid aggregation, oxidative stress and tau-phosphorylation for Alzheimer's disease
2016 · Nuria García-Font, Hasna Hayour, et al. · European Journal of Medicinal Chemistry · 52
Synthesis and biological assessment of diversely substituted furo[2,3-b]quinolin-4-amine and pyrrolo[2,3-b]quinolin-4-amine derivatives, as novel tacrine analogues
2011 · Carla Martins, M. Carmo Carreiras, et al. · European Journal of Medicinal Chemistry · 51
A practical two-step synthesis of imidazo[1,2-a]pyridines from N-(prop-2-yn-1-yl)pyridin-2-amines
2011 · David Sucunza, Abdelouahid Samadi, et al. · Chemical Communications · 51
New Quinolylnitrones for Stroke Therapy: Antioxidant and Neuroprotective (Z)-N-tert-Butyl-1-(2-chloro-6-methoxyquinolin-3-yl)methanimine Oxide as a New Lead-Compound for Ischemic Stroke Treatment
2019 · Mourad Chioua, Emma Martínez-Alonso, et al. · Journal of Medicinal Chemistry · 50
Tacripyrimidines, the first tacrine-dihydropyrimidine hybrids, as multi-target-directed ligands for Alzheimer's disease
2018 · Mourad Chioua, Eleonora Buzzi, et al. · European Journal of Medicinal Chemistry · 50
Cholinergic and neuroprotective drugs for the treatment of Alzheimer and neuronal vascular diseases. II. Synthesis, biological assessment, and molecular modelling of new tacrine analogues from highly substituted 2-aminopyridine-3-carbonitriles
2010 · Abdelouahid Samadi, Carolina Valderas, et al. · Bioorganic & Medicinal Chemistry · 48
Silver‐Catalyzed Cyclization of N‐(Prop‐2‐yn‐1‐yl)pyridin‐2‐amines
2012 · Mourad Chioua, Elena Soriano, et al. · European Journal of Organic Chemistry · 47
8-Hydroxyquinolylnitrones as multifunctional ligands for the therapy of neurodegenerative diseases
2023 · Damijan Knez, Daniel Diez-Iriepa, et al. · Acta Pharmaceutica Sinica B · 46
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Synthesis, structure, theoretical and experimental in vitro antioxidant/pharmacological properties of α-aryl, N-alkyl nitrones, as potential agents for the treatment of cerebral ischemia
2010 · Abdelouahid Samadi, Elena Soriano, et al. · Bioorganic & Medicinal Chemistry · 40
Synthesis and Pharmacological Evaluation of New N-Sulfonylureas as NLRP3 Inflammasome Inhibitors: Identification of a Hit Compound to Treat Gout
2022 · Paloma Narros-Fernández, Mourad Chioua, et al. · Journal of Medicinal Chemistry · 39
Works count: 130
Citation count: 2,489
H-index: 29
I10-index: 65
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