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Alexander Charles Lewis

Observed names: Alexander C. Lewis, Alexander C Lewis, Alexander C. Lewis, Alexander Lewis
ORCID: 0000-0002-6253-5823
Observed ORCID: 0000-0002-6253-5823
OpenAlex ID: A5044513962
Targeting sphingosine kinase 1 induces MCL1-dependent cell death in acute myeloid leukemia
2016 · Jason A. Powell, Alexander C. Lewis, et al. · Blood · 89
ROCK-mediated selective activation of PERK signalling causes fibroblast reprogramming and tumour progression through a CRELD2-dependent mechanism
2020 · Sarah Theresa Boyle, Valentina Poltavets, et al. · Nature Cell Biology · 86
Targeting sphingolipid metabolism as an approach for combination therapies in haematological malignancies
2018 · Alexander C. Lewis, Craig T. Wallington-Beddoe, et al. · Cell Death Discovery · 78
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Ceramide-induced integrated stress response overcomes Bcl-2 inhibitor resistance in acute myeloid leukemia
2022 · Alexander C. Lewis, Victoria S. Pope, et al. · Blood · 50
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Non‐genetic heterogeneity, altered cell fate and differentiation therapy
2021 · Alexander C Lewis, Lev M Kats · EMBO Molecular Medicine · 37
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Inhibition of heme biosynthesis triggers cuproptosis in acute myeloid leukemia
2025 · Alexander C. Lewis, Emily Gruber, et al. · Cell · 33
Inhibition of pyrimidine biosynthesis targets protein translation in acute myeloid leukemia
2022 · Joan So, Alexander C Lewis, et al. · EMBO Molecular Medicine · 32
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Integrated clinical and genomic evaluation of guadecitabine (SGI-110) in peripheral T-cell lymphoma
2022 · Jonathan Wong, Emily Gruber, et al. · Leukemia · 29
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Inhibition of mutant IDH1 promotes cycling of acute myeloid leukemia stem cells
2022 · Emily Gruber, Joan So, et al. · Cell Reports · 25
The sphingosine 1-phosphate receptor 2/4 antagonist JTE-013 elicits off-target effects on sphingolipid metabolism
2022 · Melissa R. Pitman, Alexander C. Lewis, et al. · Scientific Reports · 21
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Kelch-like protein 5-mediated ubiquitination of lysine 183 promotes proteasomal degradation of sphingosine kinase 1
2019 · Jason A. Powell, Melissa R. Pitman, et al. · Biochemical Journal · 15
Identification of sphingosine kinase 1 as a therapeutic target in B‐lineage acute lymphoblastic leukaemia
2018 · Craig T. Wallington‐Beddoe, Vicki Xie, et al. · British Journal of Haematology · 15
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Clinical MDR1 inhibitors enhance Smac-mimetic bioavailability to kill murine LSCs and improve survival in AML models
2020 · Emma Morrish, Anthony Copeland, et al. · Blood Advances · 12
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Publisher Correction: ROCK-mediated selective activation of PERK signalling causes fibroblast reprogramming and tumour progression through a CRELD2-dependent mechanism
2020 · Sarah Theresa Boyle, Valentina Poltavets, et al. · Nature Cell Biology · 6
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The MCL-1 inhibitor S63845: an exciting new addition to the armoury of anti-cancer agents
2017 · Jason A. Powell, Alexander C. Lewis, et al. · Journal of Xiangya Medicine · 4
The Emerging Role of Sphingolipids in Cancer Stem Cell Biology
2017 · Alexander C. Lewis, Jason A. Powell, et al. · Stem cell biology and regenerative medicine · 1
Menin regulates oncogenic cell identity transcriptional networks in multiple myeloma
2026 · Emily Gruber, Subhasree Kumar, et al. · bioRxiv (Cold Spring Harbor Laboratory)
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Inhibition of Heme Biosynthesis Triggers Cuproptosis in Acute Myeloid Leukaemia
2024 · Alexander C. Lewis, Emily Gruber, et al. · bioRxiv (Cold Spring Harbor Laboratory)
3099 – Heme Biosynthesis Is a Therapeutic Vulnerability in Acute Myeloid Leukaemia
2024 · Lev Kats, Alexander Lewis, et al. · Experimental Hematology
Quantitating and Characterizing the Effects of Epigenetic Targeted Drugs
2023 · Emily Gruber, Alexander C. Lewis, et al.
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3113 – Identification of Heme as a Critical Regulator of Leukemogenesis
2023 · Alexander Lewis, Emily Gruber, et al. · Experimental Hematology
3111 – Functional Regulation of Gene Expression, Cell Fate and Drug Response by Heme in Aml
2022 · Lev Kats, Alexander Lewis, et al. · Experimental Hematology
Inhibition of pyrimidine biosynthesis targets protein translation in AML
2021 · Joan So, Alexander C. Lewis, et al. · bioRxiv (Cold Spring Harbor Laboratory)
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Author Correction: Targeting sphingolipid metabolism as an approach for combination therapies in haematological malignancies
2021 · Alexander C. Lewis, Craig T. Wallington-Beddoe, et al. · Cell Death Discovery
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Ceramide Evokes an Apoptotic Integrated Stress Response in Acute Myeloid Leukemia
2019 · Jason Powell, Alexander Lewis, et al. · Experimental Hematology
Works count: 26
Citation count: 533
H-index: 12
I10-index: 13
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