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Tim D.D. Somerville

Observed names: T D D Somerville, T. D.D. Somerville, T. Somerville, Tim D D Somerville, Tim D. D. Somerville, Tim D. D. Somerville (15105442), Tim D. Somerville, Tim DD Somerville, Tim Somerville, Tim D.D. Somerville
Observed institutions: Ikerbasque, University of the Basque Country, Cold Spring Harbor Laboratory, University of Manchester, Epistem (United Kingdom), Cancer Research UK Manchester Institute
ORCID: 0000-0002-6295-6126
Observed ORCID: 0000-0002-6295-6126
OpenAlex ID: A5044983315
Organoid Profiling Identifies Common Responders to Chemotherapy in Pancreatic Cancer
2018 · Hervé Tiriac, Pascal Belleau, et al. · Cancer Discovery · 1,102
Enhancer Reprogramming Promotes Pancreatic Cancer Metastasis
2017 · Jae-Seok Roe, Chang-Il Hwang, et al. · Cell · 465
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POU2F3 is a master regulator of a tuft cell-like variant of small cell lung cancer
2018 · Yu-Han Huang, Olaf Klingbeil, et al. · Genes & Development · 429
TP63-Mediated Enhancer Reprogramming Drives the Squamous Subtype of Pancreatic Ductal Adenocarcinoma
2018 · Tim D.D. Somerville, Yali Xu, et al. · Cell Reports · 227
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LKB1, Salt-Inducible Kinases, and MEF2C Are Linked Dependencies in Acute Myeloid Leukemia
2018 · Yusuke Tarumoto, Bin Lu, et al. · Molecular Cell · 154
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SOAT1 promotes mevalonate pathway dependency in pancreatic cancer
2020 · Tobiloba E. Oni, Giulia Biffi, et al. · The Journal of Experimental Medicine · 126
Intraductal Transplantation Models of Human Pancreatic Ductal Adenocarcinoma Reveal Progressive Transition of Molecular Subtypes
2020 · Koji Miyabayashi, Lindsey A. Baker, et al. · Cancer Discovery · 124
BRD8 maintains glioblastoma by epigenetic reprogramming of the p53 network
2022 · Xueqin Sun, Olaf Klingbeil, et al. · Nature · 96
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Squamous trans-differentiation of pancreatic cancer cells promotes stromal inflammation
2020 · Tim DD Somerville, Giulia Biffi, et al. · eLife · 87
A targeted knockdown screen of genes coding for phosphoinositide modulators identifies PIP4K2A as required for acute myeloid leukemia cell proliferation and survival
2014 · J G Jude, G J Spencer, et al. · Oncogene · 87
Voluntary Running and Environmental Enrichment Restores Impaired Hippocampal Neurogenesis in a Triple Transgenic Mouse Model of Alzheimers Disease
2011 · J. J. Rodriguez, H. N. Noristani, et al. · Current Alzheimer Research · 85
Frequent Derepression of the Mesenchymal Transcription Factor Gene FOXC1 in Acute Myeloid Leukemia
2015 · Tim D.D. Somerville, Daniel H. Wiseman, et al. · Cancer Cell · 79
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A TFIID-SAGA Perturbation that Targets MYB and Suppresses Acute Myeloid Leukemia
2018 · Yali Xu, Joseph P. Milazzo, et al. · Cancer Cell · 74
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Mammalian SWI/SNF complex activity regulates POU2F3 and constitutes a targetable dependency in small cell lung cancer
2024 · Leslie Duplaquet, Kevin So, et al. · Cancer Cell · 71
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A Transcription Factor Addiction in Leukemia Imposed by the MLL Promoter Sequence
2018 · Bin Lu, Olaf Klingbeil, et al. · Cancer Cell · 69
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ZBED2 is an antagonist of interferon regulatory factor 1 and modifies cell identity in pancreatic cancer
2020 · Tim D. D. Somerville, Yali Xu, et al. · Proceedings of the National Academy of Sciences · 60
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Enhancers of Polycomb EPC1 and EPC2 sustain the oncogenic potential of MLL leukemia stem cells
2013 · X Huang, G J Spencer, et al. · Leukemia · 46
Phosphorylation of the Leukemic Oncoprotein EVI1 on Serine 196 Modulates DNA Binding, Transcriptional Repression and Transforming Ability
2013 · Daniel J. White, Richard D. Unwin, et al. · PLoS ONE · 45
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Derepression of the Iroquois Homeodomain Transcription Factor Gene IRX3 Confers Differentiation Block in Acute Leukemia
2018 · Tim D.D. Somerville, Fabrizio Simeoni, et al. · Cell Reports · 31
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Frequent reconstitution of IDH2R140Q mutant clonal multilineage hematopoiesis following chemotherapy for acute myeloid leukemia
2016 · D H Wiseman, E L Williams, et al. · Leukemia · 21
TTC5 is required to prevent apoptosis of acute myeloid leukemia stem cells
2013 · J T Lynch, T D D Somerville, et al. · Cell Death and Disease · 13
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Dynamic Evolution of Fibroblasts Revealed by Single-Cell RNA Sequencing of Human Pancreatic Cancer
2024 · Slavica Dimitrieva, Jon M. Harrison, et al. · Cancer Research Communications · 12
Abstract C57: Organoid profiling identifies common responders to chemotherapy in pancreatic cancer
2019 · Herve Tiriac, Pascal Belleau, et al. · Cancer Research · 11
Modeling the Epigenetic Chain Reaction Downstream of DNMT3A R882H
2016 · Tim D.D. Somerville, Christopher R. Vakoc · Cancer Cell · 3
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Tissue-inappropriate derepression of FOXC1 is frequent and functional in human acute myeloid leukemia
2016 · Tim D. D. Somerville, Tim C. P. Somervaille · Molecular & Cellular Oncology · 3
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Works count: 94
Citation count: 3,522
H-index: 20
I10-index: 23
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