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Author

Ikuko Miyaguchi

Observed name: I. Miyaguchi
ORCID: 0000-0003-0021-7296
Observed ORCID: 0000-0003-0021-7296
OpenAlex ID: A5045030058
A comparative study of the binding modes of recently launched dipeptidyl peptidase IV inhibitors in the active site
2013 · Mika Nabeno, Fumihiko Akahoshi, et al. · Biochemical and Biophysical Research Communications · 325
Discovery and preclinical profile of teneligliptin (3-[(2S,4S)-4-[4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl]pyrrolidin-2-ylcarbonyl]thiazolidine): A highly potent, selective, long-lasting and orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes
2012 · Tomohiro Yoshida, Fumihiko Akahoshi, et al. · Bioorganic & Medicinal Chemistry · 159
Transport and inhibition mechanism of the human SGLT2–MAP17 glucose transporter
2023 · Masahiro Hiraizumi, Tomoya Akashi, et al. · Nature Structural & Molecular Biology · 90
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Fused bicyclic heteroarylpiperazine-substituted l-prolylthiazolidines as highly potent DPP-4 inhibitors lacking the electrophilic nitrile group
2012 · Tomohiro Yoshida, Fumihiko Akahoshi, et al. · Bioorganic & Medicinal Chemistry · 39
Machine learning to estimate the local quality of protein crystal structures
2021 · Ikuko Miyaguchi, Miwa Sato, et al. · Scientific Reports · 7
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Structure-guided development of a potent human B0AT1 inhibitor effective in a mouse model of phenylketonuria
2026 · Takuya Imazu, Tomoya Akashi, et al. · Communications Biology · 3
Discovery of a potent, orally available furopyridine derivative as a novel selective bromodomain and extra-terminal domain (BET)-first bromodomain (BD1) inhibitor
2024 · Shuichi Hagihara, Kouhei Ishizawa, et al. · Bioorganic & Medicinal Chemistry Letters · 3
Discovery of a potent orally available pyrazolopyridone derivative as a novel selective bromodomain and extra-terminal domain (BET)-first bromodomain (BD1) inhibitor
2024 · Shuichi Hagihara, Kouhei Ishizawa, et al. · Bioorganic & Medicinal Chemistry Letters · 2
Resolution-standardized evaluation of ligand atomic coordinates in crystallographic structures using machine learning
2026 · Ikuko Miyaguchi, Hiroaki Hata, et al. · bioRxiv (Cold Spring Harbor Laboratory)
A residue-focused protein crystal structure evaluation method based on electron density
2023 · I. Miyaguchi, A. Kashima, et al. · Acta Crystallographica Section A Foundations and Advances
Crystal structure of human depiptidyl peptidase IV (DPP-4) in complex with vildagliptin
2012 · H. Kishida, M. Nabeno, et al. · Worldwide Protein Data Bank
Crystal structure of human depiptidyl peptidase IV (DPP-4) in complex with a prolylthiazolidine inhibitor #2
2011 · F. Akahoshi, H. Kishida, et al. · Worldwide Protein Data Bank
Crystal structure of human depiptidyl peptidase IV (DPP-4) in complex with a prolylthiazolidine inhibitor #1
2011 · F. Akahoshi, H. Kishida, et al. · Worldwide Protein Data Bank
Crystal Structure of alanine racemase from Corynebacterium glutamicum
2006 · I. Miyaguchi, C. Sasaki, et al. · Worldwide Protein Data Bank
Works count: 20
Citation count: 628
H-index: 5
I10-index: 4
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