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Ralph A. Casale

Observed names: R CASALE, Ralph Casale
OpenAlex ID: A5010024019
Labile exocyclic amine protection of nucleosides in DNA, RNA and oligonucleotide analog synthesis facililating N-deacylation, minimizing depurination and chain degradation
1993 · N SINHA, P DAVIS, et al. · Biochimie · 101
A PNA-transportan conjugate targeted to the TAR region of the HIV-1 genome exhibits both antiviral and virucidal properties
2004 · Binay Chaubey, Snehlata Tripathi, et al. · Virology · 50
Synthesis and properties of an oligodeoxynucleotide containing a polycyclic aromatic hydrocarbon site specifically bound to the N2 amino group of a 2'-deoxyguanosine residue
1990 · Ralph Casale, Larry W. McLaughlin · Journal of the American Chemical Society · 43
Lipoic acid analogs with enhanced pharmacological activity
2013 · Steven A. Kates, Ralph A. Casale, et al. · Bioorganic & Medicinal Chemistry · 26
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Synthesis of oligodeoxynucleoside methylphosphonates utilizing the fert-butylphenoxyacetyl group for exocyclic amine protection
1994 · Nanda D. Sinha, Dennis P. Michaud, et al. · Nucleic Acids Research · 12
CMX-2043 Efficacy in a Rat Model of Cardiac Ischemia–Reperfusion Injury
2016 · Alexander Baguisi, Ralph A. Casale, et al. · Journal of Cardiovascular Pharmacology and Therapeutics · 10
Pre‐clinical and Clinical Safety Studies of CMX ‐2043: A Cytoprotective Lipoic Acid Analogue for Ischaemia–Reperfusion Injury
2014 · Steven A. Kates, Alan S. Lader, et al. · Basic & Clinical Pharmacology & Toxicology · 9
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Synthesis of PNA Oligomers by Fmoc Chemistry
2005 · Ralph Casale, Ivar S. Jensen, et al. · ChemInform · 9
CMX-2043 Mechanisms of Action In Vitro
2016 · Alan S. Lader, Alexander Baguisi, et al. · Journal of Cardiovascular Pharmacology · 8
Ocular Hypotensive Properties and Biochemical Profile of QLS-101, a Novel ATP-Sensitive Potassium (K ATP ) Channel Opening Prodrug
2022 · Cynthia L. Pervan-Steel, Uttio Roy Chowdhury, et al. · Investigative Ophthalmology & Visual Science · 7
The Chemistry of Peptide Nucleic Acids
2001 · Michael Egholm, Ralph A. Casale · ChemInform · 7
Preclinical Pharmacokinetic Profile of Topical Ophthalmic and Intravenous Delivery of QLS-101, a Novel ATP-Sensitive Potassium Channel Opening Ocular Hypotensive Agent
2023 · Uttio Roy Chowdhury, Cynthia L. Pervan-Steel, et al. · Journal of Ocular Pharmacology and Therapeutics · 3
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The Chemistry of Peptide Nucleic Acids
2000 · Michael Egholm, Ralph A. Casale · CRC Press eBooks · 3
Preclinical Evaluation of Safety and Efficacy of QLS-111: A Novel Formulation of an Adenosine Triphosphate-Sensitive Potassium Channel Opener
2026 · Barbara M. Wirostko, Uttio Roy Chowdhury, et al. · Ophthalmology Science
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Systemic and Ocular Toxicology and Pharmacokinetic Profiles of QLS-101, a Novel Topical IOP-Lowering Therapeutic
2021 · Barbara Wirostko, H Sookdeo, et al. · Investigative Ophthalmology & Visual Science
Ocular Tissue Conversion and Activity Profile of QLS-101, a Novel Topical IOP-Lowering Therapeutic
2021 · Cynthia Steel, H Sookdeo, et al. · Investigative Ophthalmology & Visual Science
Works count: 16
Citation count: 288
H-index: 8
I10-index: 6
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