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Thomas Kirkegaard

Observed names: Kirkegaard, Thomas, T. Kirkegaard, Thomas T. Kirkegaard
ORCID: 0000-0001-5931-263X
Observed ORCID: 0000-0001-5931-263X
OpenAlex ID: A5045765682
Hsp70 stabilizes lysosomes and reverts Niemann–Pick disease-associated lysosomal pathology
2010 · Thomas Kirkegaard, Anke G. Roth, et al. · Nature · 516
Lysosomal involvement in cell death and cancer
2008 · Thomas Kirkegaard, Marja Jäättelä · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · 395
Transformation-Associated Changes in Sphingolipid Metabolism Sensitize Cells to Lysosomal Cell Death Induced by Inhibitors of Acid Sphingomyelinase
2013 · Nikolaj H.T. Petersen, Ole D. Olsen, et al. · Cancer Cell · 338
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Heat shock protein–based therapy as a potential candidate for treating the sphingolipidoses
2016 · Thomas Kirkegaard, James Gray, et al. · Science Translational Medicine · 173
Identification of Autophagosome-associated Proteins and Regulators by Quantitative Proteomic Analysis and Genetic Screens
2012 · Jörn Dengjel, Maria Høyer-Hansen, et al. · Molecular & Cellular Proteomics · 146
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BAMLET Activates a Lysosomal Cell Death Program in Cancer Cells
2010 · Paul Rammer, Line Groth-Pedersen, et al. · Molecular Cancer Therapeutics · 127
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Depletion of Kinesin 5B Affects Lysosomal Distribution and Stability and Induces Peri-Nuclear Accumulation of Autophagosomes in Cancer Cells
2009 · Carla M. P. Cardoso, Line Groth-Pedersen, et al. · PLoS ONE · 125
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Efficacy and safety of arimoclomol in Niemann‐Pick disease type C: Results from a double‐blind, randomised, placebo‐controlled, multinational phase 2/3 trial of a novel treatment
2021 · Eugen Mengel, Marc C. Patterson, et al. · Journal of Inherited Metabolic Disease · 102
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Connecting Hsp70, sphingolipid metabolism and lysosomal stability
2010 · Nikolaj H.T. Petersen, Thomas Kirkegaard, et al. · Cell Cycle · 85
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Annual severity increment score as a tool for stratifying patients with Niemann-Pick disease type C and for recruitment to clinical trials
2018 · Mario Cortina-Borja, Danielle te Vruchte, et al. · Orphanet Journal of Rare Diseases · 72
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Sunitinib and SU11652 Inhibit Acid Sphingomyelinase, Destabilize Lysosomes, and Inhibit Multidrug Resistance
2013 · Anne-Marie Ellegaard, Line Groth-Pedersen, et al. · Molecular Cancer Therapeutics · 63
Human heat shock protein 70 (Hsp70) as a peripheral membrane protein
2014 · Ajay K. Mahalka, Thomas Kirkegaard, et al. · Biochimica et Biophysica Acta (BBA) - Biomembranes · 52
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The heat shock protein amplifier arimoclomol improves refolding, maturation and lysosomal activity of glucocerebrosidase
2018 · Cathrine K. Fog, Paola Zago, et al. · EBioMedicine · 50
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Lysosomal storage diseases and the heat shock response: convergences and therapeutic opportunities
2014 · Linda Ingemann, Thomas Kirkegaard · Journal of Lipid Research · 45
Animal models for Niemann-Pick type C: implications for drug discovery & development
2019 · Cathrine K. Fog, Thomas Kirkegaard · Expert Opinion on Drug Discovery · 36
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Emerging therapies and therapeutic concepts for lysosomal storage diseases
2013 · Thomas Kirkegaard · Expert Opinion on Orphan Drugs · 34
Clinical disease progression and biomarkers in Niemann–Pick disease type C: a prospective cohort study
2020 · Eugen Mengel, Bruno Bembi, et al. · Orphanet Journal of Rare Diseases · 27
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HSP70 and lysosomal storage disorders: novel therapeutic opportunities
2010 · Nikolaj H.T. Petersen, Thomas Kirkegaard · Biochemical Society Transactions · 27
Activation of phospholipase A2 by Hsp70 in vitro
2011 · Ajay K. Mahalka, Christian Code, et al. · Biochimica et Biophysica Acta (BBA) - Biomembranes · 18
HSP70 induces liver X receptor pathway activation and cholesterol reduction in vitro and in vivo
2019 · Burcin Gungor, Lauri Vanharanta, et al. · Molecular Metabolism · 17
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Conformational dynamics of free and membrane-bound human Hsp70 in model cytosolic and endo-lysosomal environments
2021 · Valeria Calvaresi, Line T. Truelsen, et al. · Communications Biology · 15
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Heat shock protein amplification improves cerebellar myelination in the Npc1nih mouse model
2022 · James Gray, María E. Fernández-Suárez, et al. · EBioMedicine · 13
Galactosyl- and glucosylsphingosine induce lysosomal membrane permeabilization and cell death in cancer cells
2022 · Kamilla Stahl-Meyer, Mesut Bilgin, et al. · PLoS ONE · 10
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Lysosomal Stability Assay
2014 · Nikolaj Petersen, Thomas Kirkegaard, et al. · BIO-PROTOCOL · 6
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Arimoclomol increases the transcription of lysosomal genes, including and , to facilitate lysosomal function
2022 · Nikolaj H.T. Petersen, Pontus Klein, et al. · Molecular Genetics and Metabolism · 3
Works count: 47
Citation count: 2,500
H-index: 18
I10-index: 23
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