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A.J. Powell

Observed names: A. Powell, A.J Powell, Ailsa J. Powell, Ailsa Powell, Powell, A.J., Powell, Ailsa, Powell, Ailsa J.
Observed institutions: Medical University of South Carolina, Diamond Light Source, University of Bristol, Research Complex at Harwell, Institute of Liver and Biliary Sciences, Monash University
ORCID: 0000-0002-0462-2240
Observed ORCID: 0000-0002-0462-2240
OpenAlex ID: A5046432376
Crystallographic and electrophilic fragment screening of the SARS-CoV-2 main protease
2020 · Alice Douangamath, Daren Fearon, et al. · Nature Communications · 539
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SARS-CoV-2 infects the human kidney and drives fibrosis in kidney organoids
2021 · Jitske Jansen, Katharina C. Reimer, et al. · Cell stem cell · 263
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Open science discovery of potent noncovalent SARS-CoV-2 main protease inhibitors
2023 · Melissa L. Boby, Daren Fearon, et al. · Science · 238
Fragment binding to the Nsp3 macrodomain of SARS-CoV-2 identified through crystallographic screening and computational docking
2021 · Marion Schuller, Galen J. Correy, et al. · Science Advances · 207
Crystal Structures of Penicillin-binding Protein 2 from Penicillin-susceptible and -resistant Strains of Neisseria gonorrhoeae Reveal an Unexpectedly Subtle Mechanism for Antibiotic Resistance
2008 · Ailsa J. Powell, Joshua Tomberg, et al. · Journal of Biological Chemistry · 95
Recognition of structurally diverse substrates by type II 3-hydroxyacyl-CoA dehydrogenase (HADH II)/Amyloid-β binding alcohol dehydrogenase (ABAD)
2000 · A.J Powell, J.A Read, et al. · Journal of Molecular Biology · 94
Achieving Efficient Fragment Screening at XChem Facility at Diamond Light Source
2021 · Alice Douangamath, Ailsa Powell, et al. · Journal of Visualized Experiments · 77
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Crystal Structures of Complexes of Bacterial dd-Peptidases with Peptidoglycan-Mimetic Ligands: The Substrate Specificity Puzzle
2008 · Eric Sauvage, Ailsa J. Powell, et al. · Journal of Molecular Biology · 44
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Accelerating Drug Discovery With High‐Throughput Crystallographic Fragment Screening and Structural Enablement
2024 · Daren Fearon, Ailsa Powell, et al. · Applied Research · 36
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Crystal Structures of the Lytic Transglycosylase MltA from N.gonorrhoeae and E.coli: Insights into Interdomain Movements and Substrate Binding
2006 · Ailsa J. Powell, Zhi-Jie Liu, et al. · Journal of Molecular Biology · 33
SARS-CoV-2 main protease with unliganded active site (2019-nCoV, coronavirus disease 2019, COVID-19)
2020 · C.D. Owen, P. Lukacik, et al. · Worldwide Protein Data Bank · 31
Turning high-throughput structural biology into predictive inhibitor design
2023 · Kadi L. Saar, William McCorkindale, et al. · Proceedings of the National Academy of Sciences · 29
SARS-CoV-2 main protease with unliganded active site (2019-nCoV, coronavirus disease 2019, COVID-19).
2020 · C.D. Owen, P. Lukacik, et al. · Worldwide Protein Data Bank · 24
PanDDA analysis group deposition -- Crystal Structure of COVID-19 main protease in complex with Z45617795
2020 · D. Fearon, A.J. Powell, et al. · Worldwide Protein Data Bank · 13
PanDDA analysis group deposition -- Crystal Structure of SARS-CoV-2 main protease in complex with Z1220452176
2020 · D. Fearon, A.J. Powell, et al. · Worldwide Protein Data Bank · 10
PanDDA analysis group deposition -- Crystal Structure of SARS-CoV-2 main protease in complex with Z18197050
2020 · D. Fearon, A.J. Powell, et al. · Worldwide Protein Data Bank · 6
PanDDA analysis group deposition -- Crystal Structure of SARS-CoV-2 main protease in complex with Z2856434899
2020 · D. Fearon, C.D. Owen, et al. · Worldwide Protein Data Bank · 4
PanDDA analysis group deposition -- Crystal Structure of SARS-CoV-2 main protease in complex with Z44592329
2020 · D. Fearon, A.J. Powell, et al. · Worldwide Protein Data Bank · 4
PanDDA analysis group deposition -- Crystal Structure of COVID-19 main protease in complex with Z219104216
2020 · D. Fearon, A.J. Powell, et al. · Worldwide Protein Data Bank · 4
Raw diffraction data for structure of SARS-CoV-2 main protease with Z44592329 (ID: mpro-x0434 / PDB: 5R83)
2020 · Aragao, David, Brandao-Neto, Jose, et al. · Zenodo (CERN European Organization for Nuclear Research) · 3
PanDDA analysis group deposition SARS-CoV-2 main protease fragment screen -- Crystal Structure of SARS-CoV-2 main protease in complex with NCL-00024905
2020 · D. Fearon, C.D. Owen, et al. · Worldwide Protein Data Bank · 2
PanDDA analysis group deposition -- Crystal Structure of SARS-CoV-2 main protease in complex with Z1741969146
2020 · D. Fearon, C.D. Owen, et al. · Worldwide Protein Data Bank · 2
PanDDA analysis group deposition -- Crystal Structure of SARS-CoV-2 main protease in complex with PCM-0102306
2020 · D. Fearon, C.D. Owen, et al. · Worldwide Protein Data Bank · 2
PanDDA analysis group deposition of ground-state model of SARS-CoV-2 main protease screened against DSI poised (Enamine), Fraglites and Peplites (Newcastle university), Mini Frags (Astex), York 3D (York university), electrophile cysteine covalent (Weizman institute) fragment libraries
2020 · D. Fearon, C.D. Owen, et al. · Worldwide Protein Data Bank · 2
PanDDA analysis group deposition -- Crystal Structure of COVID-19 main protease in complex with Z1367324110
2020 · D. Fearon, A.J. Powell, et al. · Worldwide Protein Data Bank · 2
Works count: 582
Citation count: 1,799
H-index: 13
I10-index: 15
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