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Zhi‐Wei Lai

Observed names: Z LAI, Z. Lai, Z.W. Lai, Z.‐W. Lai, Zhi-Wei Lai, Zhi-wei Lai, Z‐W. LAI
ORCID: 0000-0001-7314-1814
Observed ORCID: 0000-0001-7314-1814
OpenAlex ID: A5046615816
N ‐acetylcysteine reduces disease activity by blocking mammalian target of rapamycin in T cells from systemic lupus erythematosus patients: A randomized, double‐blind, placebo‐controlled trial
2012 · Zhi‐Wei Lai, Robert Hanczko, et al. · Arthritis & Rheumatism · 426
Sirolimus in patients with clinically active systemic lupus erythematosus resistant to, or intolerant of, conventional medications: a single-arm, open-label, phase 1/2 trial
2018 · Zhi-Wei Lai, Ryan Kelly, et al. · The Lancet · 410
HRES-1/Rab4-mediated depletion of Drp1 impairs mitochondrial homeostasis and represents a target for treatment in SLE
2013 · Tiffany N Caza, David R Fernandez, et al. · Annals of the Rheumatic Diseases · 192
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Comprehensive metabolome analyses reveal N-acetylcysteine-responsive accumulation of kynurenine in systemic lupus erythematosus: implications for activation of the mechanistic target of rapamycin
2015 · Andras Perl, Robert Hanczko, et al. · Metabolomics · 189
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Mechanistic Target of Rapamycin Activation Triggers IL-4 Production and Necrotic Death of Double-Negative T Cells in Patients with Systemic Lupus Erythematosus
2013 · Zhi-Wei Lai, Rebecca Borsuk, et al. · The Journal of Immunology · 155
Brief Report: Attention Deficit and Hyperactivity Disorder Scores Are Elevated and Respond to N‐Acetylcysteine Treatment in Patients With Systemic Lupus Erythematosus
2013 · Ricardo J. Garcia, Lisa Francis, et al. · Arthritis & Rheumatism · 105
Identification of dioxin-responsive elements (DREs) in the 5′ regions of putative dioxin-inducible genes
1996 · Zhi-Wei Lai, Thierry Pineau, et al. · Chemico-Biological Interactions · 95
Rab4A-directed endosome traffic shapes pro-inflammatory mitochondrial metabolism in T cells via mitophagy, CD98 expression, and kynurenine-sensitive mTOR activation
2024 · Nick Huang, Thomas Winans, et al. · Nature Communications · 81
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Cytokine Gene Expression during Ontogeny in Murine Thymus on Activation of the Aryl Hydrocarbon Receptor by 2,3,7,8-Tetrachlorodibenzo-p-dioxin
1997 · Zhi-Wei Lai, Claudia Hundeiker, et al. · Molecular Pharmacology · 66
Differential Effects of Diethylstilbestrol and 2,3,7,8-Tetrachlorodibenzo-p-dioxin on Thymocyte Differentiation, Proliferation, and Apoptosis in bcl-2 Transgenic Mouse Fetal Thymus Organ Culture
2000 · Zhi-Wei Lai, Nancy C. Fiore, et al. · Toxicology and Applied Pharmacology · 45
mTOR-dependent loss of PON1 secretion and antiphospholipid autoantibody production underlie autoimmunity-mediated cirrhosis in transaldolase deficiency
2023 · T. Winans, Z. Oaks, et al. · Journal of Autoimmunity · 42
2,3,7,8-Tetrachlorodibenzo-p-dioxin and Diethylstilbestrol Affect Thymocytes at Different Stages of Development in Fetal Thymus Organ Culture
1998 · Zhi-Wei Lai, Nancy C. Fiore, et al. · Toxicology and Applied Pharmacology · 40
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Oxidative stress and Treg depletion in lupus patients with anti-phospholipid syndrome
2015 · Zhi-wei Lai, Ivan Marchena-Mendez, et al. · Clinical Immunology · 30
Evidence for the promotion of positive selection of thymocytes by Ah receptor agonist 2,3,7,8-tetrachlorodibenzo-p-dioxin
1995 · Joachim Kremer, Zhi-Wei Lai, et al. · European Journal of Pharmacology Environmental Toxicology and Pharmacology · 27
3, 3′, 4, 4′‐Tetrachlorobiphenyl Inhibits Proliferation of Immature Thymocytes in Fetal Thymus Organ Culture
1994 · Z‐W. LAI, J. KREMER, et al. · Scandinavian Journal of Immunology · 25
Dioxin-Induced Adseverin Expression in the Mouse Thymus Is Strictly Regulated and Dependent on the Aryl Hydrocarbon Receptor
2002 · Camilla Svensson, Allen E. Silverstone, et al. · Biochemical and Biophysical Research Communications · 23
Prenatal Exposure to Cigarette Smoke Alters Later-Life Antitumor Cytotoxic T-Lymphocyte (CTL) Activity Via Possible Changes in T-Regulatory Cells
2013 · Sheung P. Ng, Allen E. Silverstone, et al. · Journal of Toxicology and Environmental Health · 15
Generation of αβ T‐cell receptor+ CD4– CD8+ cells in major histocompatibility complex class I‐deficient mice upon activation of the aryl hydrocarbon receptor by 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin
2000 · S. Kronenberg, Z.‐W. Lai, et al. · Immunology · 13
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Identification of Stage-Specific Gene Modulation during Early Thymocyte Development by Whole-Genome Profiling Analysis after Aryl Hydrocarbon Receptor Activation
2010 · Michael D. Laiosa, Jeffrey H. Mills, et al. · Molecular Pharmacology · 11
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Prenatal HgCl2Exposure Alters Fetal Cell Phenotypes
2007 · Karsten Pilones, Zhi-Wei Lai, et al. · Journal of Immunotoxicology · 11
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CD8 Thymocytes Derived from 3,3′,4,4′-Tetrachlorobiphenyl-Exposed Fetal Thymuses Possess Killing Activity
1995 · Z.W. Lai, P. Griem, et al. · Toxicology and Applied Pharmacology · 10
Effects of a single dose of 2,3,7,8-tetrachlorodibenzo-p-dioxin, given at post-puberty, in senescent mice
2005 · Charlotte Esser, Swantje Steinwachs, et al. · Toxicology Letters · 9
Bcl2-Independent Chromatin Cleavage is a Very Early Event during Induction of Apoptosis in Mouse Thymocytes after Treatment with Either Dexamethasone or Ionizing Radiation
2003 · Peter J. Hahn, Zhi-Wei Lai, et al. · Radiation Research · 4
Toxicological studies on the organophosphorous insecticide methyl-ISP
1989 · Hui-qiong Wu, Zhi-wei Lai, et al. · Journal of Tongji Medical University · 3
1203 Blockade of the mechanistic target of rapamycin elicits rapid and lasting improvement of disease activity through restraining pro-inflammatory T cell lineage specification in patients with active SLE
2022 · Zhi-Wei Lai, Ryan Kelly, et al. · 1
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Works count: 32
Citation count: 2,029
H-index: 16
I10-index: 21
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