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Raymond Hui

Chemical screening methods to identify ligands that promote protein stability, protein crystallization, and structure determination
2006 · Masoud Vedadi, Frank H. Niesen, et al. · Proceedings of the National Academy of Sciences · 594
Calcium-dependent protein kinase 1 is an essential regulator of exocytosis in Toxoplasma
2010 · Sebastian Lourido, Joel Shuman, et al. · Nature · 348
Phosphorylation of Immunity-Related GTPases by a Toxoplasma gondii-Secreted Kinase Promotes Macrophage Survival and Virulence
2010 · Sarah J. Fentress, Michael S. Behnke, et al. · Cell Host & Microbe · 338
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N-myristoyltransferase inhibitors as new leads to treat sleeping sickness
2010 · Julie A. Frearson, Stephen Brand, et al. · Nature · 318
Genome-scale protein expression and structural biology of Plasmodium falciparum and related Apicomplexan organisms
2006 · Masoud Vedadi, Jocelyne Lew, et al. · Molecular and Biochemical Parasitology · 242
Structures of apicomplexan calcium-dependent protein kinases reveal mechanism of activation by calcium
2010 · Amy K Wernimont, Jennifer D Artz, et al. · Nature Structural & Molecular Biology · 238
A potent series targeting the malarial cGMP-dependent protein kinase clears infection and blocks transmission
2017 · David A. Baker, Lindsay B. Stewart, et al. · Nature Communications · 171
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Structural basis for species-selective targeting of Hsp90 in a pathogenic fungus
2019 · Luke Whitesell, Nicole Robbins, et al. · Nature Communications · 130
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Screening for Ligands Using a Generic and High-Throughput Light-Scattering-Based Assay
2006 · Guillermo A. Senisterra, Eugene Markin, et al. · SLAS DISCOVERY · 129
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Discovery of a PCAF Bromodomain Chemical Probe
2016 · Moses Moustakim, Peter G. K. Clark, et al. · Angewandte Chemie International Edition · 94
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High-throughput protein crystallization
2003 · Raymond Hui, Aled Edwards · Journal of Structural Biology · 94
The Clp Chaperones and Proteases of the Human Malaria Parasite Plasmodium falciparum
2010 · Majida El Bakkouri, Andre Pow, et al. · Journal of Molecular Biology · 90
Structures of parasitic CDPK domains point to a common mechanism of activation
2010 · Amy K. Wernimont, Merhnaz Amani, et al. · Proteins Structure Function and Bioinformatics · 84
Inhibition of Calcium Dependent Protein Kinase 1 (CDPK1) by Pyrazolopyrimidine Analogs Decreases Establishment and Reoccurrence of Central Nervous System Disease by Toxoplasma gondii
2017 · Florentine U. Rutaganira, Jennifer Barks, et al. · Journal of Medicinal Chemistry · 76
Novel structural and regulatory features of rhoptry secretory kinases in Toxoplasma gondii
2009 · Wei Qiu, Amy Wernimont, et al. · The EMBO Journal · 72
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Lipophilic analogs of zoledronate and risedronate inhibit Plasmodium geranylgeranyl diphosphate synthase (GGPPS) and exhibit potent antimalarial activity
2012 · Joo Hwan No, Fernando de Macedo Dossin, et al. · Proceedings of the National Academy of Sciences · 71
Using a Genetically Encoded Sensor to Identify Inhibitors of Toxoplasma gondii Ca2+ Signaling
2016 · Saima M. Sidik, Miryam A. Hortua Triana, et al. · Journal of Biological Chemistry · 68
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Fragment-Based Screening of a Natural Product Library against 62 Potential Malaria Drug Targets Employing Native Mass Spectrometry
2018 · Hoan Vu, Liliana Pedro, et al. · ACS Infectious Diseases · 67
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Molecular Characterization of a Novel Geranylgeranyl Pyrophosphate Synthase from Plasmodium Parasites
2010 · Jennifer D. Artz, Amy K. Wernimont, et al. · Journal of Biological Chemistry · 62
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Crystal Structure of Plasmodium falciparum Spermidine Synthase in Complex with the Substrate Decarboxylated S-adenosylmethionine and the Potent Inhibitors 4MCHA and AdoDATO
2007 · Veronica Tamu Dufe, Wei Qiu, et al. · Journal of Molecular Biology · 60
A Potent, Covalent Inhibitor of Orotidine 5‘-Monophosphate Decarboxylase with Antimalarial Activity
2007 · Angelica M. Bello, Ewa Poduch, et al. · Journal of Medicinal Chemistry · 55
Biochemical Screening of Five Protein Kinases from Plasmodium falciparum against 14,000 Cell-Active Compounds
2016 · Gregory J. Crowther, Heidi K. Hillesland, et al. · PLoS ONE · 54
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Structures of the cGMP-dependent protein kinase in malaria parasites reveal a unique structural relay mechanism for activation
2019 · Majida El Bakkouri, Imène Kouidmi, et al. · Proceedings of the National Academy of Sciences · 51
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Exploring the Trypanosoma brucei Hsp83 Potential as a Target for Structure Guided Drug Design
2013 · Juan Carlos Pizarro, Tanya Hills, et al. · PLoS neglected tropical diseases · 50
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Designing selective inhibitors for calcium-dependent protein kinases in apicomplexans
2015 · Raymond Hui, Majida El Bakkouri, et al. · Trends in Pharmacological Sciences · 49
Works count: 79
Citation count: 4,254
H-index: 33
I10-index: 46
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