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Guoyi Yan

Synthesis and biological evaluation of 4-(1,2,3-triazol-1-yl)coumarin derivatives as potential antitumor agents
2014 · Wenjuan Zhang, Zhi Li, et al. · Bioorganic & Medicinal Chemistry Letters · 153
Discovery of a PROTAC targeting ALK with in vivo activity
2021 · Guoyi Yan, Xinxin Zhong, et al. · European Journal of Medicinal Chemistry · 59
Assessing the performance of docking scoring function, FEP, MM-GBSA, and QM/MM-GBSA approaches on a series of PLK1 inhibitors
2017 · Chunlan Pu, Guoyi Yan, et al. · MedChemComm · 56
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Selective degradation of PARP2 by PROTACs via recruiting DCAF16 for triple-negative breast cancer
2022 · Chunlan Pu, Yu Tong, et al. · European Journal of Medicinal Chemistry · 55
LncRNA MAPKAPK5_AS1 facilitates cell proliferation in hepatitis B virus -related hepatocellular carcinoma
2022 · Lianyuan Tao, Deyu Li, et al. · Laboratory Investigation · 46
Design, Synthesis, and Biological Evaluation of Dimorpholine Substituted Thienopyrimidines as Potential Class I PI3K/mTOR Dual Inhibitors
2017 · Miao Zhan, Yufang Deng, et al. · Journal of Medicinal Chemistry · 44
Design, synthesis, and biological evaluation of 2,4-diamino pyrimidine derivatives as potent FAK inhibitors with anti-cancer and anti-angiogenesis activities
2021 · Shan Wang, Rong-Hong Zhang, et al. · European Journal of Medicinal Chemistry · 43
Synthesis and biological evaluation of novel 2,3-dihydrochromeno[3,4-d]imidazol-4(1H)-one derivatives as potent anticancer cell proliferation and migration agents
2016 · Xuan Han, Jiang Luo, et al. · European Journal of Medicinal Chemistry · 38
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Synthesis, biological evaluation and molecular docking study of N-(2-methoxyphenyl)-6-((4-nitrophenyl)sulfonyl)benzamide derivatives as potent HIV-1 Vif antagonists
2017 · Meng Zhou, Rong-Hua Luo, et al. · European Journal of Medicinal Chemistry · 30
Synthesis and biological evaluation of (E)-4-(3-arylvinyl-1H-indazol-6-yl)pyrimidin-2-amine derivatives as PLK4 inhibitors for the treatment of breast cancer
2017 · Zhihao Liu, Qian Lei, et al. · RSC Advances · 30
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Discovery and biological evaluation of darolutamide derivatives as inhibitors and down-regulators of wild-type AR and the mutants
2019 · Jiang Yu, Peiting Zhou, et al. · European Journal of Medicinal Chemistry · 27
Recent advances in dual PROTACs degrader strategies for disease treatment
2024 · Jianyu Liu, Yanzhuo Liu, et al. · European Journal of Medicinal Chemistry · 25
Discovery of a novel covalent CDK4/6 inhibitor based on palbociclib scaffold
2021 · Huifang Shan, Xinyu Ma, et al. · European Journal of Medicinal Chemistry · 25
Discovery and biological evaluation of novel androgen receptor antagonist for castration-resistant prostate cancer
2019 · Jiang Yu, Lanxi Zhang, et al. · European Journal of Medicinal Chemistry · 19
Discovery of 4-phenyl-2H-benzo[b][1,4]oxazin-3(4H)-one derivatives as potent and orally active PI3K/mTOR dual inhibitors
2019 · Guoyi Yan, Chunlan Pu, et al. · European Journal of Medicinal Chemistry · 18
Design, synthesis and biological evaluation of indole derivatives as Vif inhibitors
2017 · Chunlan Pu, Rong-Hua Luo, et al. · Bioorganic & Medicinal Chemistry Letters · 16
Anti-CD133 Antibody-Targeted Therapeutic Immunomagnetic Albumin Microbeads Loaded with Vincristine-Assisted to Enhance Anti-Glioblastoma Treatment
2019 · Xueqin Wang, Ping Lu, et al. · Molecular Pharmaceutics · 15
Targeting Cysteine Located Outside the Active Site: An Effective Strategy for Covalent ALKi Design
2021 · Guoyi Yan, Xinxin Zhong, et al. · Journal of Medicinal Chemistry · 14
Identification of Critical Pathways and Potential Key Genes in Poorly Differentiated Pancreatic Adenocarcinoma
2021 · Yuanxiang Lu, Dongxiao Li, et al. · OncoTargets and Therapy · 13
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Metabolically stable diphenylamine derivatives suppress androgen receptor and BET protein in prostate cancer
2020 · Jiang Yu, Peiting Zhou, et al. · Biochemical Pharmacology · 11
Identification of HDAC6 selective inhibitors: pharmacophore based virtual screening, molecular docking and molecular dynamics simulation
2020 · Guoyi Yan, Dongxiao Li, et al. · Journal of Biomolecular Structure and Dynamics · 11
Discovery of 2-Methyl-2-(4-(2-methyl-8-(1H-pyrrolo[2,3-b]pyridin-6-yl)-1H-naphtho[1,2-d]imidazol-1-yl)phenyl)propanenitrile as a Novel PI3K/mTOR Inhibitor with Enhanced Antitumor Efficacy In Vitro and In Vivo
2022 · Jie Yang, Yuanyuan Liu, et al. · Journal of Medicinal Chemistry · 10
The Discovery of Indole-2-carboxylic Acid Derivatives as Novel HIV-1 Integrase Strand Transfer Inhibitors
2023 · Yu-Chan Wang, Rong-Hong Zhang, et al. · Molecules · 9
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Design, synthesis and biological evaluation of indole-2-carboxylic acid derivatives as novel HIV-1 integrase strand transfer inhibitors
2024 · Rong-Hong Zhang, Guo-Qi Chen, et al. · RSC Advances · 8
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Lead optimization to improve the antiviral potency of 2-aminobenzamide derivatives targeting HIV-1 Vif-A3G axis
2021 · Xinxin Zhong, Ronghua Luo, et al. · European Journal of Medicinal Chemistry · 8
Works count: 49
Citation count: 865
H-index: 16
I10-index: 22
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