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Joshua Close
Observed names:
Close Joshua,
Close, J.,
Josh Close
Institution:
Blueprint Medicines (United States)
Observed institutions:
Merck & Co., Inc., Rahway, NJ, USA (United States),
Blueprint Medicines (United States),
Pharmaron (China)
ORCID:
0000-0003-0696-3759
Observed ORCID:
0000-0003-0696-3759
OpenAlex ID:
A5050403715
Exploration of the internal cavity of histone deacetylase (HDAC) with selective HDAC1/HDAC2 inhibitors (SHI-1:2)
2007
·
Joey L. Methot
, Prasun K. Chakravarty
, et al.
·
Bioorganic & Medicinal Chemistry Letters
·
192
Divergent Kinetics Differentiate the Mechanism of Action of Two HDAC Inhibitors
2014
·
Astrid M. Kral
, Nicole Ozerova
, et al.
·
Biochemistry
·
22
The Discovery of 3-((4-Chloro-3-methoxyphenyl)amino)-1-((3R,4S)-4-cyanotetrahydro-2H-pyran-3-yl)-1H-pyrazole-4-carboxamide, a Highly Ligand Efficient and Efficacious Janus Kinase 1 Selective Inhibitor with Favorable Pharmacokinetic Properties
2017
·
Tony Siu
, Jason Brubaker
, et al.
·
Journal of Medicinal Chemistry
·
21
Exploring the pharmacokinetic properties of phosphorus-containing selective HDAC 1 and 2 inhibitors (SHI-1:2)
2009
·
Richard W. Heidebrecht
, Melissa Chenard
, et al.
·
Bioorganic & Medicinal Chemistry Letters
·
21
Discovery of MK-8318, a Potent and Selective CRTh2 Receptor Antagonist for the Treatment of Asthma
2018
·
Xianhai Huang
, Jason Brubaker
, et al.
·
ACS Medicinal Chemistry Letters
·
11
Cancer-associated fibroblasts regulate DNA repair in pancreatic cancer through NDRG1-mediated R-loop processing
2026
·
Nina Kozlova
, Kayla A. Cruz
, et al.
·
Nature Cell Biology
·
9
Lead optimization of 4,4-biaryl piperidine amides as γ-secretase inhibitors
2012
·
Joshua Close
, Richard Heidebrecht
, et al.
·
Bioorganic & Medicinal Chemistry Letters
·
9
Diminishing GSH-Adduct Formation of Tricyclic Diazepine-based Mutant IDH1 Inhibitors
2022
·
Chunhui Huang
, Christian Fischer
, et al.
·
ACS Medicinal Chemistry Letters
·
4
Abstract 1717: MAP4K1 inhibition enhances immune cell activation and anti-tumor immunity in preclinical tumor models
2021
·
Kerrie Faia
, Alberto Toso
, et al.
·
Cancer Research
·
3
Discovery of potent, selective and insurmountable MRGPRX2 antagonists for mast cell-driven disorders 2308475
2026
·
Yves Millet
, Josh Close
, et al.
·
The Journal of Immunology
CCDC 865158: Experimental Crystal Structure Determination
2012
·
Close, J.
, Heidebrecht Junior, R.
, et al.
·
The Cambridge Structural Database
CCDC 865159: Experimental Crystal Structure Determination
2012
·
Close, J.
, Heidebrecht Junior, R.
, et al.
·
The Cambridge Structural Database
Abstract 5433: Prolonged histone hyperacetylation with a novel class of HDAC1/2 selective inhibitors
2010
·
Joey L. Methot
, Melissa Chenard
, et al.
·
Cancer Research
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Works count:
13
Citation count:
292
H-index:
7
I10-index:
5
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