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Florence Legendre

Cartilage tissue engineering: Molecular control of chondrocyte differentiation for proper cartilage matrix reconstruction
2014 · Magali Demoor, David Ollitrault, et al. · Biochimica et Biophysica Acta (BBA) - General Subjects · 299
JAK/STAT but Not ERK1/ERK2 Pathway Mediates Interleukin (IL)-6/Soluble IL-6R Down-regulation of Type II Collagen, Aggrecan Core, and Link Protein Transcription in Articular Chondrocytes
2003 · Florence Legendre, Jayesh Dudhia, et al. · Journal of Biological Chemistry · 182
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Interleukin-6 (IL-6) and/or Soluble IL-6 Receptor Down-regulation of Human Type II Collagen Gene Expression in Articular Chondrocytes Requires a Decrease of Sp1·Sp3 Ratio and of the Binding Activity of Both Factors to the COL2A1 Promoter
2007 · Benoît Porée, Magdalini Kypriotou, et al. · Journal of Biological Chemistry · 151
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Interleukin-1 and Transforming Growth Factor-ß 1 as Crucial Factors in Osteoarthritic Cartilage Metabolism
2008 · Jean-Pierre Pujol, Christos Chadjichristos, et al. · Connective Tissue Research · 145
Role of interleukin 6 (IL-6)/IL-6R-induced signal tranducers and activators of transcription and mitogen-activated protein kinase/extracellular.
2005 · Florence Legendre, Patrick Bogdanowicz, et al. · PubMed · 88
Interleukin‐1β impairment of transforming growth factor β1 signaling by DOWN‐REGULATION of transforming growth factor β receptor type II and up‐regulation of Smad7 in human articular chondrocytes
2007 · C. Baugé, F. Legendre, et al. · Arthritis & Rheumatism · 75
Chondroitin sulfate modulation of matrix and inflammatory gene expression in IL-1β-stimulated chondrocytes – study in hypoxic alginate bead cultures
2007 · F. Legendre, C. Baugé, et al. · Osteoarthritis and Cartilage · 69
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Chondrogenic Differentiation of Defined Equine Mesenchymal Stem Cells Derived from Umbilical Cord Blood for Use in Cartilage Repair Therapy
2018 · Mélanie Desancé, Romain Contentin, et al. · International Journal of Molecular Sciences · 56
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Enhanced Hyaline Cartilage Matrix Synthesis in Collagen Sponge Scaffolds by Using siRNA to Stabilize Chondrocytes Phenotype Cultured with Bone Morphogenetic Protein-2 Under Hypoxia
2012 · Florence Legendre, David Ollitrault, et al. · Tissue Engineering Part C Methods · 54
Enhanced chondrogenesis of bone marrow-derived stem cells by using a combinatory cell therapy strategy with BMP-2/TGF-β1, hypoxia, and COL1A1/HtrA1 siRNAs
2017 · Florence Legendre, David Ollitrault, et al. · Scientific Reports · 53
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Comparative effects of 2 antioxidants, selenomethionine and epigallocatechin-gallate, on catabolic and anabolic gene expression of articular chondrocytes.
2005 · Rina Andriamanalijaona, Madeleine Kypriotou, et al. · PubMed · 50
BMP-2, Hypoxia, and COL1A1 / HtrA1 siRNAs Favor Neo-Cartilage Hyaline Matrix Formation in Chondrocytes
2014 · David Ollitrault, Florence Legendre, et al. · Tissue Engineering Part C Methods · 49
Hypoxia Is a Critical Parameter for Chondrogenic Differentiation of Human Umbilical Cord Blood Mesenchymal Stem Cells in Type I/III Collagen Sponges
2017 · Tangni Gómez-Leduc, Mélanie Desancé, et al. · International Journal of Molecular Sciences · 46
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Chondrogenic commitment of human umbilical cord blood-derived mesenchymal stem cells in collagen matrices for cartilage engineering
2016 · Tangni Gómez-Leduc, Magalie Hervieu, et al. · Scientific Reports · 45
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In vitro engineering of human 3D chondrosarcoma: a preclinical model relevant for investigations of radiation quality impact
2015 · Dounia Houria Hamdi, Sofia Barbieri, et al. · BMC Cancer · 42
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Sox9/Sox6 and Sp1 are involved in the insulin-like growth factor-I-mediated upregulation of human type II collagen gene expression in articular chondrocytes
2012 · Emmanuelle Renard, Benoît Porée, et al. · Journal of Molecular Medicine · 41
Rhein, the metabolite of diacerhein, reduces the proliferation of osteoarthritic chondrocytes and synoviocytes without inducing apoptosis
2009 · F. Legendre, A. Heuze, et al. · Scandinavian Journal of Rheumatology · 41
Characterization and use of Equine Bone Marrow Mesenchymal Stem Cells in Equine Cartilage Engineering. Study of their Hyaline Cartilage Forming Potential when Cultured under Hypoxia within a Biomaterial in the Presence of BMP-2 and TGF-ß1
2017 · Thomas Branly, Lélia Bertoni, et al. · Stem Cell Reviews and Reports · 39
Rhein, a diacerhein-derived metabolite, modulates the expression of matrix degrading enzymes and the cell proliferation of articular chondrocytes by inhibiting ERK and JNK-AP-1 dependent pathways.
2007 · F Legendre, P Bogdanowicz, et al. · PubMed · 39
RNA Interference and BMP-2 Stimulation Allows Equine Chondrocytes Redifferentiation in 3D-Hypoxia Cell Culture Model: Application for Matrix-Induced Autologous Chondrocyte Implantation
2017 · Rodolphe Rakic, Bastien Bourdon, et al. · International Journal of Molecular Sciences · 36
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Marine Collagen Hydrolysates Downregulate the Synthesis of Pro-Catabolic and Pro-Inflammatory Markers of Osteoarthritis and Favor Collagen Production and Metabolic Activity in Equine Articular Chondrocyte Organoids
2021 · Bastien Bourdon, Romain Contentin, et al. · International Journal of Molecular Sciences · 34
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An experimentally induced osteoarthritis model in horses performed on both metacarpophalangeal and metatarsophalangeal joints: Technical, clinical, imaging, biochemical, macroscopic and microscopic characterization
2020 · Lélia Bertoni, Sandrine Jacquet-Guibon, et al. · PLoS ONE · 33
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Evaluation of Allogeneic Bone-Marrow-Derived and Umbilical Cord Blood-Derived Mesenchymal Stem Cells to Prevent the Development of Osteoarthritis in An Equine Model
2021 · Lélia Bertoni, Sandrine Jacquet-Guibon, et al. · International Journal of Molecular Sciences · 32
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Shell Extracts from the Marine Bivalve Pecten maximus Regulate the Synthesis of Extracellular Matrix in Primary Cultured Human Skin Fibroblasts
2014 · Thomas Latire, Florence Legendre, et al. · PLoS ONE · 29
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Functionalized Nanogels with Endothelin-1 and Bradykinin Receptor Antagonist Peptides Decrease Inflammatory and Cartilage Degradation Markers of Osteoarthritis in a Horse Organoid Model of Cartilage
2022 · Aurélie Cullier, Frédéric Cassé, et al. · International Journal of Molecular Sciences · 28
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Works count: 72
Citation count: 1,903
H-index: 25
I10-index: 31
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