Author

Kui K. Chan

Observed names: Chan, Kui, K.K. Chan, Kui Chan, Kui K Chan, Kui. K. Chan

Observed institutions: Albert Einstein College of Medicine, Genomatica (United States), University of Illinois Urbana-Champaign, University of Illinois System, Cyrus Biotechnology, University at Buffalo, State University of New York

ORCID: 0000-0002-6351-2885

Observed ORCID: 0000-0002-6351-2885

OpenAlex ID: A5050724615

Engineering human ACE2 to optimize binding to the spike protein of SARS coronavirus 2

2020 · Kui K. Chan, Danielle Dorosky, et al. · Science · 624

An engineered decoy receptor for SARS-CoV-2 broadly binds protein S sequence variants

2021 · Kui K. Chan, Timothy J.C. Tan, et al. · Science Advances · 147

Engineered ACE2 decoy mitigates lung injury and death induced by SARS-CoV-2 variants

2022 · Lianghui Zhang, Soumajit Dutta, et al. · Nature Chemical Biology · 87

PDF

Formation and Stability of a Vinyl Carbanion at the Active Site of Orotidine 5‘-Monophosphate Decarboxylase: p K a of the C-6 Proton of Enzyme-Bound UMP

2008 · Tina L. Amyes, Bryant M. Wood, et al. · Journal of the American Chemical Society · 77

Mechanism of the Orotidine 5′-Monophosphate Decarboxylase-Catalyzed Reaction: Evidence for Substrate Destabilization ,

2009 · Kui K. Chan, B. McKay Wood, et al. · Biochemistry · 64

An ACE2 decoy can be administered by inhalation and potently targets omicron variants of SARS‐CoV‐2

2022 · Lianghui Zhang, Krishna K Narayanan, et al. · EMBO Molecular Medicine · 52

PDF

Product Deuterium Isotope Effect for Orotidine 5‘-Monophosphate Decarboxylase: Evidence for the Existence of a Short-Lived Carbanion Intermediate

2007 · Krisztina Toth, Tina L. Amyes, et al. · Journal of the American Chemical Society · 48

Mechanism of the Orotidine 5′-Monophosphate Decarboxylase-Catalyzed Reaction: Effect of Solvent Viscosity on Kinetic Constants

2009 · B. McKay Wood, Kui K. Chan, et al. · Biochemistry · 40

An Examination of the Relationship between Active Site Loop Size and Thermodynamic Activation Parameters for Orotidine 5′-Monophosphate Decarboxylase from Mesophilic and Thermophilic Organisms

2009 · Krisztina Toth, Tina L. Amyes, et al. · Biochemistry · 37

Computationally Designed ACE2 Decoy Receptor Binds SARS-CoV-2 Spike (S) Protein with Tight Nanomolar Affinity

2021 · Brandon Havranek, Kui K. Chan, et al. · Journal of Chemical Information and Modeling · 33

Product Deuterium Isotope Effects for Orotidine 5′-Monophosphate Decarboxylase: Effect of Changing Substrate and Enzyme Structure on the Partitioning of the Vinyl Carbanion Reaction Intermediate

2010 · Krisztina Toth, Tina L. Amyes, et al. · Journal of the American Chemical Society · 26

Structural Basis for Substrate Specificity in Phosphate Binding (β/α)8-Barrels: d -Allulose 6-Phosphate 3-Epimerase from Escherichia coli K-12

2008 · Kui K. Chan, Alexander A. Fedorov, et al. · Biochemistry · 26

Modulation of the pharmacokinetics of soluble ACE2 decoy receptors through glycosylation

2024 · Savanna Skeeters, Kamal Bagale, et al. · Molecular Therapy — Methods & Clinical Development · 11

Machine Learning Guided Design of High-Affinity ACE2 Decoys for SARS-CoV-2 Neutralization

2023 · Matthew C. Chan, Kui. K. Chan, et al. · The Journal of Physical Chemistry B · 9

PDF

Introduction of a polar core into the de novo designed protein T op7

2016 · Benjamin Basanta, Kui K. Chan, et al. · Protein Science · 9

PDF

Computationally engineered ACE2 decoy binds with nanomolar affinity with the SARS-CoV-2 spike protein

2022 · Mohammad S. Islam, Brandon Havranek, et al. · Biophysical Journal · 2

Protein Engineering of Coenzyme‐A‐Dependent Aldehyde Dehydrogenase for Commercial Scale 1,4‐Butanediol Production in Escherichia coli

2015 · Amit Shah, Wayne Liu, et al. · The FASEB Journal · 1

CHAPTER 7. EnzymeWorks: Recent Advances in Enzyme Engineering for Chemical Synthesis

2017 · Kui K. Chan, Ju Xin, et al. · RSC catalysis series

Application of High‐Throughput Screening in Biocatalysis

2016 · Xin Ju, Jie Zhang, et al. · Wiley eBooks

Solution NMR Structure of DE NOVO DESIGNED Top7 Fold Protein Top7m13, Northeast Structural Genomics Consortium (NESG) Target OR33

2013 · Liu, Gaohua, Zanghellini, Alexandre L., et al. · Biological Magnetic Resonance Bank

Crystal structure of the mutant D70G of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with uridine 5'-monophosphate