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Shaarika Sarasija
Observed name:
Sarasija, Shaarika
Institution:
Humane World for Animals
Observed institutions:
Humane World for Animals,
University of Ottawa,
uOttawa Brain and Mind Research Institute,
Albany Medical College
ORCID:
0000-0002-3610-2178
Observed ORCID:
0000-0002-3610-2178
OpenAlex ID:
A5055324773
Works
16
Awards
1
Presenilin mutations deregulate mitochondrial Ca2+ homeostasis and metabolic activity causing neurodegeneration in Caenorhabditis elegans
2018
·
Shaarika Sarasija
, Jocelyn T Laboy
, et al.
·
eLife
·
89
A γ-Secretase Independent Role for Presenilin in Calcium Homeostasis Impacts Mitochondrial Function and Morphology in Caenorhabditis elegans
2015
·
Shaarika Sarasija
, Kenneth R Norman
·
Genetics
·
70
PDF
The Role of Neuroglial Metabotropic Glutamate Receptors in Alzheimer’s Disease
2021
·
Khaled S. Abd-Elrahman
, Shaarika Sarasija
, et al.
·
Current Neuropharmacology
·
41
PDF
A positive allosteric modulator for the muscarinic receptor (M1 mAChR) improves pathology and cognitive deficits in female APPswe /PSEN1ΔE9 mice
2021
·
Khaled S. Abd‐Elrahman
, Shaarika Sarasija
, et al.
·
British Journal of Pharmacology
·
37
Role of Presenilin in Mitochondrial Oxidative Stress and Neurodegeneration in Caenorhabditis elegans
2018
·
Shaarika Sarasija
, Kenneth R. Norman
·
Antioxidants
·
31
PDF
Analysis of Mitochondrial Structure in the Body Wall Muscle of Caenorhabditis elegans
2018
·
Shaarika Sarasija
, KENNETH NORMAN
·
BIO-PROTOCOL
·
31
Measurement of ROS in Caenorhabditis elegans Using a Reduced Form of Fluorescein
2018
·
Shaarika Sarasija
, KENNETH NORMAN
·
BIO-PROTOCOL
·
30
Increased mitochondrial calcium uptake and concomitant mitochondrial activity by presenilin loss promotes mTORC1 signaling to drive neurodegeneration
2021
·
Kerry C. Ryan
, Zahra Ashkavand
, et al.
·
Aging Cell
·
28
PDF
Corrupted ER‐mitochondrial calcium homeostasis promotes the collapse of proteostasis
2019
·
Zahra Ashkavand
, Shaarika Sarasija
, et al.
·
Aging Cell
·
28
PDF
A M1 muscarinic acetylcholine receptor-specific positive allosteric modulator VU0486846 reduces neurogliosis in female Alzheimer’s mice
2024
·
Khaled S. Abd-Elrahman
, Tash-Lynn L. Colson
, et al.
·
Biomedicine & Pharmacotherapy
·
18
Author Guide for Addressing Animal Methods Bias in Publishing
2023
·
Catharine E. Krebs
, Celean Camp
, et al.
·
Advanced Science
·
18
PDF
Measurement of Oxygen Consumption Rates in Intact Caenorhabditis elegans
2019
·
Shaarika Sarasija
, Kenneth R. Norman
·
Journal of Visualized Experiments
·
9
Evaluating the translational value of preclinical models: Available tools and frameworks, challenges and strategies
2025
·
Francesca Pistollato
, Fabia Furtmann
, et al.
·
Alternatives to Laboratory Animals
·
6
Increased Mitochondrial Calcium Uptake and Concomitant Hyperactivity by Presenilin Loss Promotes mTORC1 Signaling to Drive Neurodegeneration
2020
·
Kerry C. Ryan
, Zahra Ashkavand
, et al.
·
Research Square
·
2
PDF
Author response: Presenilin mutations deregulate mitochondrial Ca2+ homeostasis and metabolic activity causing neurodegeneration in Caenorhabditis elegans
2018
·
Shaarika Sarasija
, Jocelyn T Laboy
, et al.
·
eLife
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Works count:
16
Citation count:
438
H-index:
11
I10-index:
11
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