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Author

Gerd Bader

Observed names: Bader, Gerd, G Bader, G. Bader
Observed institutions: Boehringer Ingelheim (Germany), Max Planck Society, Humboldt-Universität zu Berlin, Boehringer Ingelheim (Austria), Max Planck Institute of Biochemistry, Technical University of Munich
ORCID: 0000-0002-8410-3415
Observed ORCID: 0000-0002-8410-3415
OpenAlex ID: A5055761451
BIBF 1120: Triple Angiokinase Inhibitor with Sustained Receptor Blockade and Good Antitumor Efficacy
2008 · Frank Hilberg, Gerald J. Roth, et al. · Cancer Research · 1,085
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Target Binding Properties and Cellular Activity of Afatinib (BIBW 2992), an Irreversible ErbB Family Blocker
2012 · Flavio Solca, Goeran Dahl, et al. · Journal of Pharmacology and Experimental Therapeutics · 880
BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design
2019 · William Farnaby, Manfred Koegl, et al. · Nature Chemical Biology · 573
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A selective and orally bioavailable VHL-recruiting PROTAC achieves SMARCA2 degradation in vivo
2022 · Christiane Kofink, Nicole Trainor, et al. · Nature Communications · 246
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Structure-Based Design of an in Vivo Active Selective BRD9 Inhibitor
2016 · Laetitia J. Martin, Manfred Koegl, et al. · Journal of Medicinal Chemistry · 230
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Chemically Induced Degradation of the Oncogenic Transcription Factor BCL6
2017 · Nina Kerres, Steffen Steurer, et al. · Cell Reports · 213
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Sensitivity and engineered resistance of myeloid leukemia cells to BRD9 inhibition
2016 · Anja F Hohmann, Laetitia J Martin, et al. · Nature Chemical Biology · 190
Start Selective and Rigidify: The Discovery Path toward a Next Generation of EGFR Tyrosine Kinase Inhibitors
2019 · Harald Engelhardt, Dietrich Böse, et al. · Journal of Medicinal Chemistry · 169
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Werner syndrome helicase is a selective vulnerability of microsatellite instability-high tumor cells
2019 · Simone Lieb, Silvia Blaha-Ostermann, et al. · eLife · 157
Zinc plays a key role in human and bacterial GTP cyclohydrolase I
2000 · Günter Auerbach, Anja Herrmann, et al. · Proceedings of the National Academy of Sciences · 142
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Highly Selective PTK2 Proteolysis Targeting Chimeras to Probe Focal Adhesion Kinase Scaffolding Functions
2019 · Johannes Popow, Heribert Arnhof, et al. · Journal of Medicinal Chemistry · 137
Investigations of the Mechanism of Membrane Activity of Selected Triterpenoid Saponins
2001 · Matthias F. Melzig, Gerd Bader, et al. · Planta Medica · 130
A Novel RAF Kinase Inhibitor with DFG-Out–Binding Mode: High Efficacy in BRAF-Mutant Tumor Xenograft Models in the Absence of Normal Tissue Hyperproliferation
2016 · Irene C. Waizenegger, Anke Baum, et al. · Molecular Cancer Therapeutics · 101
The crystal structure of dihydrofolate reductase from Thermotoga maritima: molecular features of thermostability
2000 · Thomas Dams, Günter Auerbach, et al. · Journal of Molecular Biology · 97
Biosynthesis of Pteridines. Reaction Mechanism of GTP Cyclohydrolase I
2003 · Jorge Rebelo, Günter Auerbach, et al. · Journal of Molecular Biology · 81
Intracellular Trapping of the Selective Phosphoglycerate Dehydrogenase (PHGDH) Inhibitor BI-4924 Disrupts Serine Biosynthesis
2019 · Harald Weinstabl, Matthias Treu, et al. · Journal of Medicinal Chemistry · 80
PI by NMR: Probing CH–π Interactions in Protein–Ligand Complexes by NMR Spectroscopy
2020 · Gerald Platzer, Moriz Mayer, et al. · Angewandte Chemie International Edition · 79
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One Atom Makes All the Difference: Getting a Foot in the Door between SOS1 and KRAS
2021 · Juergen Ramharter, Dirk Kessler, et al. · Journal of Medicinal Chemistry · 72
Efficacy of the highly selective focal adhesion kinase inhibitor BI 853520 in adenocarcinoma xenograft models is linked to a mesenchymal tumor phenotype
2018 · Ulrich A. Hirt, Irene C. Waizenegger, et al. · Oncogenesis · 63
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Discovery of potent and selective HER2 inhibitors with efficacy against HER2 exon 20 insertion-driven tumors, which preserve wild-type EGFR signaling
2022 · Birgit Wilding, Dirk Scharn, et al. · Nature Cancer · 61
Structure and Properties of an Engineered Transketolase from Maize
2003 · Stefan Gerhardt, Stefanie Echt, et al. · PLANT PHYSIOLOGY · 57
HUWE1 employs a giant substrate-binding ring to feed and regulate its HECT E3 domain
2021 · Daniel B. Grabarczyk, Olga A. Petrova, et al. · Nature Chemical Biology · 56
Immunomodulatory and antitumoral effects of triterpenoid saponins.
1997 · B Plohmann, G Bader, et al. · PubMed · 53
SMARCA2-deficiency confers sensitivity to targeted inhibition of SMARCA4 in esophageal squamous cell carcinoma cell lines
2019 · Katharina Ehrenhöfer-Wölfer, Teresa Puchner, et al. · Scientific Reports · 51
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STAG1 vulnerabilities for exploiting cohesin synthetic lethality in STAG2-deficient cancers
2020 · Petra van der Lelij, Joseph A Newman, et al. · Life Science Alliance · 43
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Works count: 185
Citation count: 5,499
H-index: 27
I10-index: 47
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