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Siân Lax

Observed names: Lax, S, Lax, Sian, Lax, Sian; id_orcid 0000-0002-0248-8973, Lax, Siân, S Lax, S. Lax, Sian Lax
ORCID: 0000-0002-0248-8973
Observed ORCID: 0000-0002-0248-8973
OpenAlex ID: A5055918130
Vitamin D deficiency contributes directly to the acute respiratory distress syndrome (ARDS)
2015 · R. C. A. Dancer, D. Parekh, et al. · Thorax · 324
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Fibroblasts as novel therapeutic targets in chronic inflammation
2007 · S J Flavell, T Z Hou, et al. · British Journal of Pharmacology · 192
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Inflammation drives thrombosis after Salmonella infection via CLEC-2 on platelets
2015 · Jessica R. Hitchcock, Charlotte N. Cook, et al. · Journal of Clinical Investigation · 180
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The podoplanin-CLEC-2 axis inhibits inflammation in sepsis
2017 · Julie Rayes, Siân Lax, et al. · Nature Communications · 157
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Pericytes promote selective vessel regression to regulate vascular patterning
2012 · Nicole Simonavicius, Matthew Ashenden, et al. · Blood · 130
Keratinocyte Differentiation Is Regulated by the Rho and ROCK Signaling Pathway
2003 · Rachel McMullan, Siân Lax, et al. · Current Biology · 129
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Appropriation of GPIbα from platelet-derived extracellular vesicles supports monocyte recruitment in systemic inflammation
2019 · Myriam Chimen, Aigli Evryviadou, et al. · Haematologica · 103
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Prolonged, granulocyte–macrophage colony-stimulating factor-dependent, neutrophil survival following rheumatoid synovial fibroblast activation by IL-17 and TNFalpha
2008 · Greg Parsonage, Andrew Filer, et al. · Arthritis Research & Therapy · 95
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The contribution of platelet glycoprotein receptors to inflammatory bleeding prevention is stimulus and organ dependent
2018 · Julie Rayes, Soumaya Jadoui, et al. · Haematologica · 80
Platelet CLEC-2 protects against lung injury via effects of its ligand podoplanin on inflammatory alveolar macrophages in the mouse
2017 · Siân Lax, Julie Rayes, et al. · American Journal of Physiology-Lung Cellular and Molecular Physiology · 68
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Vitamin D Deficiency in Human and Murine Sepsis*
2016 · Dhruv Parekh, Jaimin M. Patel, et al. · Critical Care Medicine · 66
Platelet glycoprotein VI and C-type lectin-like receptor 2 deficiency accelerates wound healing by impairing vascular integrity in mice
2019 · Surasak Wichaiyo, Sian Lax, et al. · Haematologica · 62
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CD248/Endosialin is dynamically expressed on a subset of stromal cells during lymphoid tissue development, splenic remodeling and repair
2007 · Siân Lax, Tie Zheng Hou, et al. · FEBS Letters · 60
Lysophosphatidic acid induces process retraction in CG‐4 line oligodendrocytes and oligodendrocyte precursor cells but not in differentiated oligodendrocytes
2003 · John Dawson, Neil Hotchin, et al. · Journal of Neurochemistry · 54
The pericyte and stromal cell marker CD248 (endosialin) is required for efficient lymph node expansion
2010 · Siân Lax, Debbie L. Hardie, et al. · European Journal of Immunology · 46
Thymic Function Is Maintained during Salmonella-Induced Atrophy and Recovery
2012 · Ewan A Ross, Ruth E Coughlan, et al. · The Journal of Immunology · 43
The stromal cell antigen CD248 (endosialin) is expressed on naive CD8+ human T cells and regulates proliferation
2011 · Debbie L. Hardie, Mathew J. Baldwin, et al. · Immunology · 42
A Novel Role for PECAM-1 (CD31) in Regulating Haematopoietic Progenitor Cell Compartmentalization between the Peripheral Blood and Bone Marrow
2008 · Ewan A. Ross, Sylvie Freeman, et al. · PLoS ONE · 37
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Using a non-invasive assessment of lung injury in a murine model of acute lung injury
2014 · Siân Lax, Michael R Wilson, et al. · BMJ Open Respiratory Research · 35
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A randomised phase II trial of temozolomide with or without cannabinoids in patients with recurrent glioblastoma (ARISTOCRAT): protocol for a multi-centre, double-blind, placebo-controlled trial
2024 · Divyalakshmi Bhaskaran, Joshua Savage, et al. · BMC Cancer · 34
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Vitamin D to prevent acute lung injury following oesophagectomy (VINDALOO): study protocol for a randomised placebo controlled trial
2013 · Dhruv Parekh, Rachel C A Dancer, et al. · Trials · 33
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Immunogenicity of third dose COVID-19 vaccine strategies in patients who are immunocompromised with suboptimal immunity following two doses (OCTAVE-DUO): an open-label, multicentre, randomised, controlled, phase 3 trial
2024 · Carl S Goodyear, Amit Patel, et al. · The Lancet Rheumatology · 31
CD248 expression on mesenchymal stromal cells is required for post‐natal and infection‐dependent thymus remodelling and regeneration
2012 · Siân Lax, Ewan A. Ross, et al. · FEBS Open Bio · 30
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Lymphatic blood filling in CLEC-2-deficient mouse models
2020 · Elizabeth J Haining, Kate L Lowe, et al. · Platelets · 22
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Impaired alveolar macrophage 11β-hydroxysteroid dehydrogenase type 1 reductase activity contributes to increased pulmonary inflammation and mortality in sepsis-related ARDS
2023 · Rahul Y. Mahida, Siân Lax, et al. · Frontiers in Immunology · 20
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Works count: 78
Citation count: 2,126
H-index: 23
I10-index: 27
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