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Heike Brötz‐Oesterhelt

Observed names: Broetz-Oesterhelt, Heike, Brötz-Oesterhelt, Heike, H BROTZOESTERHELT, H Brötz-Oesterhelt, H. Broetz-Oesterheldt, H. Brotz-Oesterhelt, H. Brötz-Oesterhelt, Heike Broetz-Oesterhelt, Heike Broetz‐Oesterhelt, Heike Brötz-Oesterhelt, Heike Brötz-Oesterhelt, Heike Brötz-oesterhelt
ORCID: 0000-0001-9364-1832
Observed ORCID: 0000-0001-9364-1832
OpenAlex ID: A5056224393
Towards the sustainable discovery and development of new antibiotics
2021 · Marcus Miethke, Marco Pieroni, et al. · Nature Reviews Chemistry · 1,152
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Human commensals producing a novel antibiotic impair pathogen colonization
2016 · Alexander Zipperer, Martin C. Konnerth, et al. · Nature · 937
Dysregulation of bacterial proteolytic machinery by a new class of antibiotics
2005 · Heike Brötz-Oesterhelt, Dieter Beyer, et al. · Nature Medicine · 503
The microbiome-shaping roles of bacteriocins
2021 · Simon Heilbronner, Bernhard Krismer, et al. · Nature Reviews Microbiology · 395
Small cationic antimicrobial peptides delocalize peripheral membrane proteins
2014 · Michaela Wenzel, Alina Iulia Chiriac, et al. · Proceedings of the National Academy of Sciences · 340
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Inducing Secondary Metabolite Production by the Endophytic Fungus Fusarium tricinctum through Coculture with Bacillus subtilis
2013 · Antonius R. B. Ola, Dhana Thomy, et al. · Journal of Natural Products · 234
Structures of ClpP in complex with acyldepsipeptide antibiotics reveal its activation mechanism
2010 · Byung-Gil Lee, Eun Young Park, et al. · Nature Structural & Molecular Biology · 226
The antibiotic ADEP reprogrammes ClpP, switching it from a regulated to an uncontrolled protease
2009 · Janine Kirstein, Anja Hoffmann, et al. · EMBO Molecular Medicine · 221
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Antibiotic acyldepsipeptides activate ClpP peptidase to degrade the cell division protein FtsZ
2011 · Peter Sass, Michaele Josten, et al. · Proceedings of the National Academy of Sciences · 194
Sophisticated natural products as antibiotics
2024 · Kim Lewis, Richard E. Lee, et al. · Nature · 140
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AAA+ chaperones and acyldepsipeptides activate the ClpP protease via conformational control
2015 · Malte Gersch, Kirsten Famulla, et al. · Nature Communications · 131
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How many modes of action should an antibiotic have?
2008 · H BROTZOESTERHELT, N BRUNNER · Current Opinion in Pharmacology · 125
Specific and Potent Inhibition of NAD+-dependent DNA Ligase by Pyridochromanones
2003 · Heike Brötz-Oesterhelt, Igor Knezevic, et al. · Journal of Biological Chemistry · 118
Postgenomic Strategies in Antibacterial Drug Discovery
2010 · Heike Brötz-Oesterhelt, Peter Sass · Future Microbiology · 103
Bacterial cell division as a target for new antibiotics
2013 · Peter Sass, Heike Brötz-Oesterhelt · Current Opinion in Microbiology · 90
Medicinal Chemistry Optimization of Acyldepsipeptides of the Enopeptin Class Antibiotics
2006 · Berthold Hinzen, Siegfried Raddatz, et al. · ChemMedChem · 90
Acyldepsipeptide antibiotics kill mycobacteria by preventing the physiological functions of the ClpP1P2 protease
2016 · Kirsten Famulla, Peter Sass, et al. · Molecular Microbiology · 88
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Bioactive polyketides and alkaloids from Penicillium citrinum , a fungal endophyte isolated from Ocimum tenuiflorum
2013 · Daowan Lai, Heike Brötz-Oesterhelt, et al. · Fitoterapia · 86
Ubiquitously expressed Human Beta Defensin 1 (hBD1) forms bacteria-entrapping nets in a redox dependent mode of action
2017 · Judith Raschig, Daniela Mailänder-Sánchez, et al. · PLoS Pathogens · 85
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Bacterial caseinolytic proteases as novel targets for antibacterial treatment
2013 · Heike Brötz-Oesterhelt, Peter Sass · International Journal of Medical Microbiology · 84
Conformational control of the bacterial Clp protease by natural product antibiotics
2017 · I. T. Malik, H. Brötz-Oesterhelt · Natural Product Reports · 83
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The impact of transcriptome and proteome analyses on antibiotic drug discovery
2004 · Christoph Freiberg, Heike Brötz-Oesterhelt, et al. · Current Opinion in Microbiology · 83
Atropisomeric Dihydroanthracenones as Inhibitors of Multiresistant Staphylococcus aureus
2013 · Robert Bara, Ilka Zerfass, et al. · Journal of Medicinal Chemistry · 78
Bacterial proteomics and its role in antibacterial drug discovery
2004 · Heike Brötz‐Oesterhelt, Julia Elisabeth Bandow, et al. · Mass Spectrometry Reviews · 78
Synthetic Lugdunin Analogues Reveal Essential Structural Motifs for Antimicrobial Action and Proton Translocation Capability
2019 · Nadine A. Schilling, Anne Berscheid, et al. · Angewandte Chemie International Edition · 76
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Works count: 185
Citation count: 7,311
H-index: 39
I10-index: 74
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