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Jaeok Park

Observed names: J. Park, Jae Park, Park, Jaeok
Observed institutions: Memorial University of Newfoundland, PROTEO, Université Laval, McGill University, Columbia University, McMaster University
ORCID: 0000-0002-8180-3950
Observed ORCID: 0000-0002-8180-3950
OpenAlex ID: A5057012441
Adenosine kinase and ribokinase – the RK family of proteins
2008 · J. Park, R. S. Gupta · Cellular and Molecular Life Sciences · 144
Inhibition of farnesyl pyrophosphate (FPP) and/or geranylgeranyl pyrophosphate (GGPP) biosynthesis and its implication in the treatment of cancers
2019 · Daniel D. Waller, Jaeok Park, et al. · Critical Reviews in Biochemistry and Molecular Biology · 86
Structural and functional insights into esterase-mediated macrolide resistance
2021 · Michał Zieliński, Jaeok Park, et al. · Nature Communications · 66
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Subcellular localization of adenosine kinase in mammalian cells: The long isoform of AdK is localized in the nucleus
2009 · Xianying Amy Cui, Bhag Singh, et al. · Biochemical and Biophysical Research Communications · 66
Human farnesyl pyrophosphate synthase is allosterically inhibited by its own product
2017 · Jaeok Park, Michal Zielinski, et al. · Nature Communications · 59
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Regulation of endocytic trafficking and acidification are independent of the cystic fibrosis transmembrane regulator.
1994 · K.W. Dunn, J. Park, et al. · Journal of Biological Chemistry · 55
Design and Synthesis of Active Site Inhibitors of the Human Farnesyl Pyrophosphate Synthase: Apoptosis and Inhibition of ERK Phosphorylation in Multiple Myeloma Cells
2012 · Yih-Shyan Lin, Jaeok Park, et al. · Journal of Medicinal Chemistry · 52
Identification and characterization of human ribokinase and comparison of its properties with E. coli ribokinase and human adenosine kinase
2007 · Jae Park, Paul van Koeverden, et al. · FEBS Letters · 52
Human isoprenoid synthase enzymes as therapeutic targets
2014 · Jaeok Park, Alexios N. Matralis, et al. · Frontiers in Chemistry · 50
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Thienopyrimidine Bisphosphonate (ThPBP) Inhibitors of the Human Farnesyl Pyrophosphate Synthase: Optimization and Characterization of the Mode of Inhibition
2013 · Chun Yuen Leung, Jaeok Park, et al. · Journal of Medicinal Chemistry · 47
Unraveling the Prenylation–Cancer Paradox in Multiple Myeloma with Novel Geranylgeranyl Pyrophosphate Synthase (GGPPS) Inhibitors
2018 · Cyrus M. Lacbay, Daniel D. Waller, et al. · Journal of Medicinal Chemistry · 45
Multistage Screening Reveals Chameleon Ligands of the Human Farnesyl Pyrophosphate Synthase: Implications to Drug Discovery for Neurodegenerative Diseases
2014 · Joris W. De Schutter, Jaeok Park, et al. · Journal of Medicinal Chemistry · 35
Maintenance of Native-like Protein Dynamics May Not Be Required for Engineering Functional Proteins
2014 · Sophie M.C. Gobeil, Christopher M. Clouthier, et al. · Chemistry & Biology · 32
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Pharmacophore Mapping of Thienopyrimidine-Based Monophosphonate (ThP-MP) Inhibitors of the Human Farnesyl Pyrophosphate Synthase
2017 · Jaeok Park, Chun Yuen Leung, et al. · Journal of Medicinal Chemistry · 28
Ternary complex structures of human farnesyl pyrophosphate synthase bound with a novel inhibitor and secondary ligands provide insights into the molecular details of the enzyme’s active site closure
2012 · Jaeok Park, Yih-Shyan Lin, et al. · BMC Structural Biology · 26
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A potential gain-of-function variant of SLC9A6 leads to endosomal alkalinization and neuronal atrophy associated with Christianson Syndrome
2018 · Alina Ilie, Andy Y.L. Gao, et al. · Neurobiology of Disease · 24
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The Structural Dynamics of Engineered β-Lactamases Vary Broadly on Three Timescales yet Sustain Native Function
2019 · Sophie M. C. Gobeil, Maximillian C. C. J. C. Ebert, et al. · Scientific Reports · 22
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Probing the molecular and structural elements of ligands binding to the active site versus an allosteric pocket of the human farnesyl pyrophosphate synthase
2015 · Dimitrios Gritzalis, Jaeok Park, et al. · Bioorganic & Medicinal Chemistry Letters · 17
Chirality-Driven Mode of Binding of α-Aminophosphonic Acid-Based Allosteric Inhibitors of the Human Farnesyl Pyrophosphate Synthase (hFPPS)
2019 · Yuting Feng, Jaeok Park, et al. · Journal of Medicinal Chemistry · 15
Inhibition of adenosine kinase by phosphonate and bisphosphonate derivatives
2006 · Jae Park, Bhag Singh, et al. · Molecular and Cellular Biochemistry · 15
Phosphorylated Derivatives That Activate or Inhibit Mammalian Adenosine Kinase Provide Insights into the Role of Pentavalent Ions in AK Catalysis
2004 · Jae Park, Bhag Singh, et al. · The Protein Journal · 15
Synthesis and Evaluation of Structurally Diverse C-2-Substituted Thienopyrimidine-Based Inhibitors of the Human Geranylgeranyl Pyrophosphate Synthase
2022 · Hiu-Fung Lee, Cyrus M. Lacbay, et al. · Journal of Medicinal Chemistry · 11
Crystallographic and thermodynamic characterization of phenylaminopyridine bisphosphonates binding to human farnesyl pyrophosphate synthase
2017 · Jaeok Park, Dmitry Rodionov, et al. · PLoS ONE · 10
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Structure of human farnesyl pyrophosphate synthase in complex with an aminopyridine bisphosphonate and two molecules of inorganic phosphate
2014 · Jaeok Park, Yih-Shyan Lin, et al. · Acta Crystallographica Section F Structural Biology Communications · 9
Mycobacterial adenosine kinase is not a typical adenosine kinase
2009 · Jae Park, Bhag Singh, et al. · FEBS Letters · 9
Works count: 35
Citation count: 1,011
H-index: 17
I10-index: 23
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