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Hisham A. Nematalla

Observed names: Hesham Nematalla, Hisham A. Nematallah, Hisham Ah Nematalla, Hisham Nematalla
ORCID: 0000-0002-7218-4115
Observed ORCID: 0000-0002-7218-4115
OpenAlex ID: A5057370642
Highly efficient Pyrococcus furiosus recombinant L-asparaginase with no glutaminase activity: Expression, purification, functional characterization, and cytotoxicity on THP-1, A549 and Caco-2 cell lines
2020 · Hesham Saeed, Asmaa Hemida, et al. · International Journal of Biological Macromolecules · 62
Synthesis, anti-inflammatory screening, molecular docking, and COX-1,2/-5-LOX inhibition profile of some novel quinoline derivatives
2018 · Ibrahim Chaaban, Ola H. Rizk, et al. · Bioorganic Chemistry · 44
Inclusion of Nitrofurantoin into the Realm of Cancer Chemotherapy via Biology-Oriented Synthesis and Drug Repurposing
2023 · Perihan A. Elzahhar, Hisham A. Nematalla, et al. · Journal of Medicinal Chemistry · 24
Liraglutide and Naringenin relieve depressive symptoms in mice by enhancing Neurogenesis and reducing inflammation
2024 · Yara S. Abdelkawy, Mona Elharoun, et al. · European Journal of Pharmacology · 23
Portulaca oleracea L. (purslane) improves the anti-inflammatory, antioxidant and autophagic actions of metformin in the hippocampus of diabetic demented rats
2023 · Salma F. Hassan, Asser I. Ghoneim, et al. · Fitoterapia · 18
Pseudomonas aeruginosa recombinant L-asparaginase: Large scale production, purification, and cytotoxicity on THP-1, MDA-MB-231, A549, Caco2 and HCT-116 cell lines
2021 · Hesham Saeed, Asmaa Hemida, et al. · Protein Expression and Purification · 17
Novel Nose-to-brain delivery of carbenoxolone via mucoadhesive solid lipid nanoparticles for Parkinson’s symptoms management: In vitro and in vivo evaluation in a rotenone-induced rat model
2025 · Hisham A. Nematalla, Mona Elharoun, et al. · International Journal of Pharmaceutics · 15
Click-modifiable isatin hydrazones as COX-2, VEGFR-2, and carbonic anhydrase inhibitors: A multi-target approach to cancer therapy
2025 · Maryam A.Z. El-Attar, Ola S. Afifi, et al. · European Journal of Medicinal Chemistry · 10
Novel thiazolones for the simultaneous modulation of PPARγ, COX-2 and 15-LOX to address metabolic disease-associated portal inflammation
2025 · Mai S. El-Shoukrofy, Azza Ismail, et al. · European Journal of Medicinal Chemistry · 10
L-asparaginase from Dickeya chrysanthemi: expression, purification and cytotoxicity assessment
2021 · Hesham Saeed, Eman Elsawy, et al. · Preparative Biochemistry & Biotechnology · 9
Multi-Target Glitazones for Modulating Peroxisome Proliferator-Activated Receptor-γ, Cyclooxygenase-2, and Carbonic Anhydrases for the Management of Metabolic Dysfunction
2025 · Perihan A. Elzahhar, Hisham A. Nematalla, et al. · ACS Pharmacology & Translational Science · 7
Ultrasmall lactoferrin/lipid multicompartmental nanomedicine-based reprogramming of glycolysis in triple-negative breast cancer via HDAC6/LDH axis enhances cancer immunotherapy
2025 · Islam A. Hassanin, Hesham M. Saeed, et al. · Chemical Engineering Journal · 7
Synergistic effect of Dactolisib/Lys05 combination on autophagy in A549 cells
2023 · Mohammad Abdelwahab, Hesham Saeed, et al. · Acta Biochimica Polonica · 7
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Innovative approach in Parkinson’s targeting via berberine-loaded mucoadhesive surface-modified liposomes: a multi-faceted study
2025 · Hisham A. Nematalla, Mona Elharoun, et al. · BMC Pharmacology and Toxicology · 6
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Enhanced therapeutic efficacy of asparaginase and chloroquine co-loaded ZIF-8 nanoparticles for overcoming l-asparaginase resistance in leukemia treatment
2024 · Ahmed N. Shama, Hesham Saeed, et al. · Journal of Drug Delivery Science and Technology · 6
Revisiting multi-pathway modulation with theophylline derivatives: Targeting STAT3, NF-κB, and apoptotic signaling in breast cancer
2025 · Ola S. Afifi, Amira A. Abdellatef, et al. · Bioorganic Chemistry · 4
Effect of Nano-Gefitinib on Solid Ehrlich Carcinoma via Targeting EGFR, RIPK2 Pathways, and Macrophage Reprogramming
2025 · Neveen R. Ashoura, Hebatallah M. Saad, et al. · Pharmaceuticals · 3
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Glucagon-like peptide-1 agonists alleviate adenine-induced nephrotoxicity in rats: interaction with the renin-angiotensin system and role of NLRP-3 inflammasome, nephrin and KIM-1
2025 · Hisham A. Nematalla, Mona Elharoun, et al. · Biochemical Pharmacology · 2
Protective effects of glycine against diclofenac-induced toxicity in isolated rat hepatocytes
2025 · Mostafa G. Elkot, Hisham A. Nematalla, et al. · Drug and Chemical Toxicology · 2
Nano-Cilostazol Mitigates Cisplatin-Induced Nephrotoxicity in Rats via Modulation of Oxidative Stress, Apoptosis, Pyroptosis, and miRNA-155 Signaling
2026 · Hebatallah M. Saad, Enas I. El Zahaby, et al. · Antioxidants · 1
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Amino acids protect against methotrexate-induced hepatorenal toxicity in vitro and in vivo
2026 · Basma M. Abdelaziz, Hisham A. Nematalla, et al. · Naunyn-Schmiedeberg s Archives of Pharmacology · 1
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Novel furanone-based anticancer agents: Design, synthesis, Hsp90 inhibition, in vivo antitumor activity and pharmacokinetic studies
2025 · Gina N. Tageldin, Hisham A. Nematalla, et al. · European Journal of Medicinal Chemistry · 1
Exploring Escherichia coli EGY Type II L-Asparaginase Variant of Unique Glutaminase Activity: Cloning, Expression, Biochemical Characterization, and Molecular Docking Analysis
2025 · Rawan Alshamy, Nehal Aly, et al. · Current Microbiology · 1
Pseudomonas aeruginosa Recombinant L-asparaginase: PEGylation with Low Molecular Weight Polyethylene Glycol, Molecular Dynamics Simulation, In vitro and In vivo Serum half-life and Biochemical Characterization
2024 · Rawan Alshamy, Nefertiti El-Nikhely, et al. · Current Pharmaceutical Biotechnology · 1
Targeting Vascular Smooth Muscle Cell Senescence for Cardiovascular Pharmacology: Mechanisms and Therapeutic Perspectives
2026 · Alex El Darzi, Roy El Darzi, et al. · Journal of Cardiovascular Pharmacology
Works count: 34
Citation count: 281
H-index: 9
I10-index: 9
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