Get started
Author

John R. Klune

Observed names: J R Klune, J. Klune, J. Robert Klune, J.R. Klune, John Klune, John R Klune, John Robert Klune
Observed institutions: Christiana Care Health System, National Institutes of Health, University of Maryland Medical Center, University of Pittsburgh, Georgetown University, Anne Arundel Medical Center, UPMC Presbyterian, University of Pittsburgh Medical Center, University of Colorado Denver
ORCID: 0009-0009-4105-990X
Observed ORCID: 0009-0009-4105-990X
OpenAlex ID: A5058466017
HMGB1: Endogenous Danger Signaling
2008 · John R. Klune, Rajeev Dhupar, et al. · Molecular Medicine · 779
PDF
HMGB1 release induced by liver ischemia involves Toll-like receptor 4–dependent reactive oxygen species production and calcium-mediated signaling
2007 · Allan Tsung, John R. Klune, et al. · The Journal of Experimental Medicine · 627
PDF
High Mobility Group Box 1 Release from Hepatocytes during Ischemia and Reperfusion Injury Is Mediated by Decreased Histone Deacetylase Activity
2010 · John Evankovich, Sung W. Cho, et al. · Journal of Biological Chemistry · 249
PDF
Molecular Biology of Liver Ischemia/Reperfusion Injury: Established Mechanisms and Recent Advancements
2010 · John R. Klune, Allan Tsung · Surgical Clinics of North America · 214
Noninvasive radiofrequency ablation of cancer targeted by gold nanoparticles
2008 · Jon Cardinal, John Robert Klune, et al. · Surgery · 203
Hepatocyte-Specific High-Mobility Group Box 1 Deletion Worsens the Injury in Liver Ischemia/Reperfusion: A Role for Intracellular High-Mobility Group Box 1 in Cellular Protection
2013 · Hai Huang, Gary W. Nace, et al. · Hepatology · 150
PDF
Cellular-specific role of toll-like receptor 4 in hepatic ischemia-reperfusion injury in mice
2013 · Gary W. Nace, Hai Huang, et al. · Hepatology · 125
Increasing numbers of hepatic dendritic cells promote HMGB1-mediated ischemia-reperfusion injury
2006 · Allan Tsung, Ning Zheng, et al. · Journal of Leukocyte Biology · 121
Interferon Regulatory Factor 1 Mediates Acetylation and Release of High Mobility Group Box 1 from Hepatocytes During Murine Liver Ischemia-Reperfusion Injury
2010 · Rajeev Dhupar, John R. Klune, et al. · Shock · 88
Critical Role of Interferon Regulatory Factor-1 in Murine Liver Transplant Ischemia Reperfusion Injury
2009 · Shinya Ueki, Rajeev Dhupar, et al. · Hepatology · 64
PDF
Arginase blockade protects against hepatic damage in warm ischemia-reperfusion
2008 · Geetha Jeyabalan, John R. Klune, et al. · Nitric Oxide · 53
Delayed operating room availability significantly impacts the total hospital costs of an urgent surgical procedure
2011 · Rajeev Dhupar, John Evankovich, et al. · Surgery · 49
PDF
Interferon regulatory factor-2 is protective against hepatic ischemia-reperfusion injury
2012 · John R. Klune, Rajeev Dhupar, et al. · American Journal of Physiology-Gastrointestinal and Liver Physiology · 39
A Novel Inhibitory Peptide of Toll-like Receptor Signaling Limits Lipopolysaccharide-induced Production of Inflammatory Mediators and Enhances Survival in Mice
2007 · Allan Tsung, Sharon L. McCoy, et al. · Shock · 36
HMGB1 preconditioning: therapeutic application for a danger signalõ
2007 · J R Klune, T R Billiar, et al. · Journal of Leukocyte Biology · 29
IL-23 mediates murine liver transplantation ischemia-reperfusion injury via IFN-γ/IRF-1 pathway
2018 · John R. Klune, Christian Bartels, et al. · American Journal of Physiology-Gastrointestinal and Liver Physiology · 27
PDF
Analysis of 10-year trends in Medicare Physician Fee Schedule payments in surgery
2024 · Udai S. Sibia, Janelle-Cheri Millen, et al. · Surgery · 20
Hospital-Based Same-Day Compared to Overnight-Stay Mastectomy: An American College of Surgeons National Surgical Quality Improvement Program Analysis
2022 · Udai S. Sibia, John R. Klune, et al. · Ochsner Journal · 19
PDF
Outcomes of Laparoscopic vs Open Repair of Perforated Peptic Ulcers: An ACS-NSQIP Study
2021 · Shyam S. Jayaraman, Rebecca Allen, et al. · Journal of Surgical Research · 19
Aged Human Stored Red Blood Cell Supernatant Inhibits Macrophage Phagocytosis in an HMGB1 Dependent Manner After Trauma in a Murine Model
2016 · Kent R. Zettel, Mitchell Dyer, et al. · Shock · 15
Isolated skeletal muscle metastasis following successful treatment of laryngeal cancer: case report
2010 · John R Klune, Brian Zuckerbraun, et al. · International Seminars in Surgical Oncology · 11
PDF
Indocyanine green does not decrease the need for bail-out operation in an acute care surgery population
2020 · Justin Turcotte, S. Daniel Leydorf, et al. · Surgery · 10
Impact of Frailty Upon Surgical Decision-Making for Left-Sided Colon Cancer
2023 · Udai S. Sibia, Shivani B. Badve, et al. · Ochsner Journal · 9
PDF
Does routine postoperative contrast radiography improve outcomes for patients with perforated peptic ulcer? A multicenter retrospective cohort study
2021 · Shyam S. Jayaraman, Shreyus S. Kulkarni, et al. · Surgery · 8
How Does a New General Surgery Residency Program's Junior Residents Impact Hospital Efficiency and Productivity?
2019 · Udai S. Sibia, Justin J. Turcotte, et al. · Journal of surgical education · 7
Works count: 83
Citation count: 3,011
H-index: 19
I10-index: 22
Year
Topic
Type