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Author

Duncan C. Humphries

Observed names: D. Humphries, D.C., Humphries, DC Humphries, Duncan C Humphries, Duncan Charles Humphries, Duncan Humphries, Humphries, Duncan C.
Institution: Galecto (Denmark)
Observed institutions: Sanofi (France), Galecto (Denmark), MRC Centre for Regenerative Medicine, Centre for Inflammation Research, The Queen's Medical Research Institute, University of Edinburgh
ORCID: 0000-0002-5551-6536
Observed ORCID: 0000-0002-5551-6536
OpenAlex ID: A5059020857
Target inhibition of galectin-3 by inhaled TD139 in patients with idiopathic pulmonary fibrosis
2020 · Nikhil Hirani, Alison C. MacKinnon, et al. · European Respiratory Journal · 243
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Cellular senescence inhibits renal regeneration after injury in mice, with senolytic treatment promoting repair
2021 · Katie J. Mylonas, Eoin D. O’Sullivan, et al. · Science Translational Medicine · 225
Kidney Single-Cell Atlas Reveals Myeloid Heterogeneity in Progression and Regression of Kidney Disease
2020 · Bryan R. Conway, Eoin D. O’Sullivan, et al. · Journal of the American Society of Nephrology · 207
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Monocytes Control Second-Phase Neutrophil Emigration in Established Lipopolysaccharide-induced Murine Lung Injury
2012 · Kevin Dhaliwal, Emma Scholefield, et al. · American Journal of Respiratory and Critical Care Medicine · 130
Novel role for endogenous mitochondrial formylated peptide-driven formyl peptide receptor 1 signalling in acute respiratory distress syndrome
2017 · David A Dorward, Christopher D Lucas, et al. · Thorax · 89
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Chemical Modulation of in Vivo Macrophage Function with Subpopulation-Specific Fluorescent Prodrug Conjugates
2017 · Antonio Fernandez, Matthieu Vermeren, et al. · ACS Central Science · 82
The transcription factor EGR2 is indispensable for tissue-specific imprinting of alveolar macrophages in health and tissue repair
2021 · Jack McCowan, Frédéric Fercoq, et al. · Science Immunology · 76
Hypoxia drives murine neutrophil protein scavenging to maintain central carbon metabolism
2021 · Emily R. Watts, Andrew J.M. Howden, et al. · Journal of Clinical Investigation · 48
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An Inhaled Galectin-3 Inhibitor in COVID-19 Pneumonitis: A Phase Ib/IIa Randomized Controlled Clinical Trial (DEFINE)
2022 · Erin E. Gaughan, Tom M. Quinn, et al. · American Journal of Respiratory and Critical Care Medicine · 42
Heat shock protein 90 inhibition abrogates TLR4-mediated NF-κB activity and reduces renal ischemia-reperfusion injury
2015 · Stephen O’Neill, Duncan Humphries, et al. · Scientific Reports · 41
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Galectin-3 inhibitor GB0139 protects against acute lung injury by inhibiting neutrophil recruitment and activation
2022 · Duncan C. Humphries, Ross Mills, et al. · Frontiers in Pharmacology · 34
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Selective Myeloid Depletion of Galectin-3 Offers Protection Against Acute and Chronic Lung Injury
2021 · Duncan C. Humphries, Ross Mills, et al. · Frontiers in Pharmacology · 33
Semaphorin 3F signaling actively retains neutrophils at sites of inflammation
2020 · Tracie Plant, Suttida Eamsamarng, et al. · Journal of Clinical Investigation · 31
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Activated neutrophil fluorescent imaging technique for human lungs
2021 · Thomas H. Craven, Tashfeen Walton, et al. · Scientific Reports · 28
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Pulmonary-Resident Memory Lymphocytes: Pivotal Orchestrators of Local Immunity Against Respiratory Infections
2021 · Duncan C. Humphries, Richard A. O’Connor, et al. · Frontiers in Immunology · 21
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Effect of GB1107, a novel galectin-3 inhibitor on pro-fibrotic signalling in the liver
2024 · Alison C. MacKinnon, Duncan C. Humphries, et al. · European Journal of Pharmacology · 19
Cerebral Concussion Primes the Lungs for Subsequent Neutrophil-Mediated Injury
2018 · Duncan C. Humphries, Stephen O’Neill, et al. · Critical Care Medicine · 12
Specific in situ immuno-imaging of pulmonary-resident memory lymphocytes in human lungs
2023 · Duncan C. Humphries, Richard A. O’Connor, et al. · Frontiers in Immunology · 10
Fast and Robust Single-Exponential Decay Recovery From Noisy Fluorescence Lifetime Imaging
2022 · Ali Taimori, Duncan Humphries, et al. · IEEE Transactions on Biomedical Engineering · 10
Galectin-1 Induces the Production of Immune-Suppressive Cytokines in Human and Mouse T Cells
2024 · Kimberly D. Herman, Ian Holyer, et al. · International Journal of Molecular Sciences · 7
Pharmacological Characterization of GB1908, a Selective Galectin-1 Carbohydrate Binding Domain Inhibitor for the Treatment of Cancer
2025 · Kimberly D. Herman, Ian Holyer, et al. · Pharmacology · 3
Deletion of Galectin-3 in Myeloid Cells Inhibits Bleomycin-Induced Lung Fibrosis
2019 · A.C. Mackinnon, D. Humphries, et al. · American Journal of Respiratory and Critical Care Medicine · 2
P129 Orally active galectin-3 inhibitors attenuate bleomycin induced lung fibrosis
2016 · Alison C. MacKinnon, Duncan Humphries, et al. · QJM · 2
S133 Hypoxia drives a hyperinflammatory neutrophil phenotype in the lung
2019 · ER Watts, AJM Howden, et al. · Thorax · 1
The effect of the galectin-3 inhibitor GB0139 on acute lung injury
2022 · Humphries, Duncan C., Mills, Ross, et al. · Zenodo (CERN European Organization for Nuclear Research)
Works count: 28
Citation count: 1,396
H-index: 16
I10-index: 19
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