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Darren Orton

Small-molecule inhibition of Wnt signaling through activation of casein kinase 1α
2010 · Curtis A Thorne, Alison J Hanson, et al. · Nature Chemical Biology · 485
An allosteric potentiator of M4 mAChR modulates hippocampal synaptic transmission
2007 · Jana K Shirey, Zixiu Xiang, et al. · Nature Chemical Biology · 161
Discovery and Characterization of Novel Allosteric Potentiators of M1 Muscarinic Receptors Reveals Multiple Modes of Activity
2008 · Joy E. Marlo, Colleen M. Niswender, et al. · Molecular Pharmacology · 146
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Context-Dependent Pharmacology Exhibited by Negative Allosteric Modulators of Metabotropic Glutamate Receptor 7
2009 · Colleen M. Niswender, Kari A. Johnson, et al. · Molecular Pharmacology · 82
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The Small Molecule IMR-1 Inhibits the Notch Transcriptional Activation Complex to Suppress Tumorigenesis
2016 · Luisana Astudillo, Thiago G. Da Silva, et al. · Cancer Research · 79
SU11248 (Sunitinib) Sensitizes Pancreatic Cancer to the Cytotoxic Effects of Ionizing Radiation
2008 · Kyle C. Cuneo, Ling Geng, et al. · International Journal of Radiation Oncology*Biology*Physics · 77
Pyrvinium Attenuates Hedgehog Signaling Downstream of Smoothened
2014 · Bin Li, Dennis Liang Fei, et al. · Cancer Research · 76
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Targeting the Wnt Pathway in Synovial Sarcoma Models
2013 · Whitney Barham, Andrea L. Frump, et al. · Cancer Discovery · 75
Repurposing the FDA-Approved Pinworm Drug Pyrvinium as a Novel Chemotherapeutic Agent for Intestinal Polyposis
2014 · Bin Li, Colin A. Flaveny, et al. · PLoS ONE · 65
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Differential abundance of CK1α provides selectivity for pharmacological CK1α activators to target WNT-dependent tumors
2017 · Bin Li, Darren Orton, et al. · Science Signaling · 51
The Antihelmintic Drug Pyrvinium Pamoate Targets Aggressive Breast Cancer
2013 · Wei Xu, Lara Lacerda, et al. · PLoS ONE · 47
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A CK1α Activator Penetrates the Brain and Shows Efficacy Against Drug-resistant Metastatic Medulloblastoma
2018 · Jezabel Rodriguez-Blanco, Bin Li, et al. · Clinical Cancer Research · 34
Pharmacological Disruption of the Notch1 Transcriptional Complex Inhibits Tumor Growth by Selectively Targeting Cancer Stem Cells
2021 · Annamil Alvarez-Trotta, William Guerrant, et al. · Cancer Research · 26
A Biochemical Screen for Identification of Small-Molecule Regulators of the Wnt Pathway Using Xenopus Egg Extracts
2011 · Curtis A. Thorne, Bonnie Lafleur, et al. · SLAS DISCOVERY · 17
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Permissive antagonism induced by novel allosteric antagonists of metabotropic glutamate receptor 7
2006 · Colleen M. Niswender, Kailey Myers, et al. · Research Portal (Queen's University Belfast) · 2
Supplementary Figures S2 and S3 from Targeting the Wnt Pathway in Synovial Sarcoma Models
2023 · Whitney Barham, Andrea L. Frump, et al.
Supplementary Figures S4 - S7 from Targeting the Wnt Pathway in Synovial Sarcoma Models
2023 · Whitney Barham, Andrea L. Frump, et al.
Supplementary Figure S8 from Targeting the Wnt Pathway in Synovial Sarcoma Models
2023 · Whitney Barham, Andrea L. Frump, et al.
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Supplementary Figure S1 from Targeting the Wnt Pathway in Synovial Sarcoma Models
2023 · Whitney Barham, Andrea L. Frump, et al.
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Supplementary Figure S11 and Tables S1-S3 from Targeting the Wnt Pathway in Synovial Sarcoma Models
2023 · Whitney Barham, Andrea L. Frump, et al.
Supplementary Methods and Legends from Targeting the Wnt Pathway in Synovial Sarcoma Models
2023 · Whitney Barham, Andrea L. Frump, et al.
Supplementary Figure S10 from Targeting the Wnt Pathway in Synovial Sarcoma Models
2023 · Whitney Barham, Andrea L. Frump, et al.
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Supplementary Figure S9 from Targeting the Wnt Pathway in Synovial Sarcoma Models
2023 · Whitney Barham, Andrea L. Frump, et al.
Supplementary Figures S4 - S7 from Targeting the Wnt Pathway in Synovial Sarcoma Models
2023 · Whitney Barham, Andrea L. Frump, et al.
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Supplementary Figure S1 from Targeting the Wnt Pathway in Synovial Sarcoma Models
2023 · Whitney Barham, Andrea L. Frump, et al.
Works count: 78
Citation count: 1,423
H-index: 14
I10-index: 14
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