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Kristian Birchall

Observed names: Birchall, K, Birchall, Kristian, K. Birchall
Institution: LifeArc
ORCID: 0000-0001-9992-2555
Observed ORCID: 0000-0001-9992-2555
OpenAlex ID: A5059606387
A potent series targeting the malarial cGMP-dependent protein kinase clears infection and blocks transmission
2017 · David A. Baker, Lindsay B. Stewart, et al. · Nature Communications · 172
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Fragment-based hit identification: thinking in 3D
2013 · Andrew D. Morley, Angelo Pugliese, et al. · Drug Discovery Today · 165
Antitubercular specific activity of ibuprofen and the other 2-arylpropanoic acids using the HT-SPOTi whole-cell phenotypic assay
2013 · Juan D Guzman, Dimitrios Evangelopoulos, et al. · BMJ Open · 95
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Competitive Binding of a Benzimidazole to the Histone-Binding Pocket of the Pygo PHD Finger
2014 · Thomas C. R. Miller, Trevor J. Rutherford, et al. · ACS Chemical Biology · 67
Characterization of Three Druggable Hot-Spots in the Aurora-A/TPX2 Interaction Using Biochemical, Biophysical, and Fragment-Based Approaches
2017 · Patrick J. McIntyre, Patrick M. Collins, et al. · ACS Chemical Biology · 59
Substituted imidazopyridazines are potent and selective inhibitors of Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1)
2013 · Timothy M. Chapman, Simon A. Osborne, et al. · Bioorganic & Medicinal Chemistry Letters · 55
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Optimization of an Imidazopyridazine Series of Inhibitors of Plasmodium falciparum Calcium-Dependent Protein Kinase 1 (PfCDPK1)
2014 · Timothy M. Chapman, Simon A. Osborne, et al. · Journal of Medicinal Chemistry · 53
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Synthesis and structure–activity relationships of a novel series of pyrimidines as potent inhibitors of TBK1/IKKε kinases
2012 · Edward G. McIver, Justin Bryans, et al. · Bioorganic & Medicinal Chemistry Letters · 51
The serine proteinase hepsin is an activator of pro-matrix metalloproteinases: molecular mechanisms and implications for extracellular matrix turnover
2017 · David J. Wilkinson, Antoine Desilets, et al. · Scientific Reports · 47
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The future of machine learning for small-molecule drug discovery will be driven by data
2024 · Guy Durant, Fergus Boyles, et al. · Nature Computational Science · 46
Design, Synthesis, and Testing of Potent, Selective Hepsin Inhibitors via Application of an Automated Closed-Loop Optimization Platform
2018 · Shishir M. Pant, Amanda Mukonoweshuro, et al. · Journal of Medicinal Chemistry · 45
Biochemical and Antiparasitic Properties of Inhibitors of the Plasmodium falciparum Calcium-Dependent Protein Kinase PfCDPK1
2014 · Keith H. Ansell, Hayley M. Jones, et al. · Antimicrobial Agents and Chemotherapy · 34
Incorporating Target-Specific Pharmacophoric Information into Deep Generative Models for Fragment Elaboration
2022 · Thomas E. Hadfield, Fergus Imrie, et al. · Journal of Chemical Information and Modeling · 33
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Targeted protein degradation in CNS disorders: a promising route to novel therapeutics?
2024 · Sandra Kuemper, Andrew G. Cairns, et al. · Frontiers in Molecular Neuroscience · 32
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Development of a differential scanning fluorimetry based high throughput screening assay for the discovery of affinity binders against an anthrax protein
2010 · Fiona J. Sorrell, Gemma K. Greenwood, et al. · Journal of Pharmaceutical and Biomedical Analysis · 31
Use of Reduced Graphs To Encode Bioisosterism for Similarity-Based Virtual Screening
2009 · Kristian Birchall, Valerie J. Gillet, et al. · Journal of Chemical Information and Modeling · 31
Robustly interrogating machine learning-based scoring functions: what are they learning?
2025 · Guy Durant, Fergus Boyles, et al. · Bioinformatics · 28
Training Similarity Measures for Specific Activities: Application to Reduced Graphs
2006 · Kristian Birchall, Valerie J. Gillet, et al. · Journal of Chemical Information and Modeling · 28
Evolving Interpretable Structure−Activity Relationship Models. 2. Using Multiobjective Optimization To Derive Multiple Models
2008 · Kristian Birchall, Valerie J. Gillet, et al. · Journal of Chemical Information and Modeling · 27
Characterizing the binding and function of TARP γ8-selective AMPA receptor modulators
2020 · Jan-Niklas Dohrke, Jake F. Watson, et al. · Journal of Biological Chemistry · 26
Trisubstituted thiazoles as potent and selective inhibitors of Plasmodium falciparum protein kinase G (PfPKG)
2018 · Denise J. Tsagris, Kristian Birchall, et al. · Bioorganic & Medicinal Chemistry Letters · 25
Evolving Interpretable Structure−Activity Relationships. 1. Reduced Graph Queries
2008 · Kristian Birchall, Valerie J. Gillet, et al. · Journal of Chemical Information and Modeling · 22
Potent inhibitors of malarial P. Falciparum protein kinase G: Improving the cell activity of a series of imidazopyridines
2018 · Jonathan M. Large, Kristian Birchall, et al. · Bioorganic & Medicinal Chemistry Letters · 20
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Reduced Graphs and Their Applications in Chemoinformatics
2010 · Kristian Birchall, Valerie J. Gillet · Methods in molecular biology · 19
Discovery of potent and selective 5-azaindazole inhibitors of leucine-rich repeat kinase 2 (LRRK2) – Part 1
2018 · Joanne Osborne, Kristian Birchall, et al. · Bioorganic & Medicinal Chemistry Letters · 17
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Works count: 42
Citation count: 1,293
H-index: 22
I10-index: 29
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