Author

Ester Muraglia

Observed names: E Muraglia, E. MURAGLIA, E. Muraglia, Muraglia, Ester

Observed institutions: Merck & Co., Inc., Rahway, NJ, USA (United States), Institute of Molecular Biology and Pathology, IRBM, Sapienza University of Rome

OpenAlex ID: A5059883181

Discovery of Raltegravir, a Potent, Selective Orally Bioavailable HIV-Integrase Inhibitor for the Treatment of HIV-AIDS Infection

2008 · Vincenzo Summa, Alessia Petrocchi, et al. · Journal of Medicinal Chemistry · 653

Molecular Insights into Quorum Sensing in the Human Pathogen Pseudomonas aeruginosa from the Structure of the Virulence Regulator LasR Bound to Its Autoinducer

2007 · Matthew J. Bottomley, Ester Muraglia, et al. · Journal of Biological Chemistry · 473

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In Vitro Selection and Characterization of Hepatitis C Virus Serine Protease Variants Resistant to an Active-Site Peptide Inhibitor

2003 · Caterina Trozzi, Linda Bartholomew, et al. · Journal of Virology · 117

4,5-Dihydroxypyrimidine Carboxamides and N-Alkyl-5-hydroxypyrimidinone Carboxamides Are Potent, Selective HIV Integrase Inhibitors with Good Pharmacokinetic Profiles in Preclinical Species

2006 · Vincenzo Summa, Alessia Petrocchi, et al. · Journal of Medicinal Chemistry · 104

Tetrazole thioacetanilides: Potent non-nucleoside inhibitors of WT HIV reverse transcriptase and its K103N mutant

2006 · Ester Muraglia, Olaf D. Kinzel, et al. · Bioorganic & Medicinal Chemistry Letters · 90

Homolytic substitution reactions of electron-rich pentatomic heteroaromatics by electrophilic carbon-centered radicals. Synthesis of .alpha.-heteroarylacetic acids

1992 · Enrico Baciocchi, Ester Muraglia, et al. · The Journal of Organic Chemistry · 82

A novel, inducible, eukaryotic gene expression system based on the quorum‐sensing transcription factor TraR

2003 · Petra Neddermann, Cesare Gargioli, et al. · EMBO Reports · 81

Dihydroxypyrimidine-4-carboxamides as Novel Potent and Selective HIV Integrase Inhibitors

2007 · Paola Pace, M. Emilia Di Francesco, et al. · Journal of Medicinal Chemistry · 80

Discovery and Synthesis of HIV Integrase Inhibitors: Development of Potent and Orally Bioavailable N-Methyl Pyrimidones

2007 · Cristina Gardelli, Emanuela Nizi, et al. · Journal of Medicinal Chemistry · 67

Identification of Novel, Selective, and Stable Inhibitors of Class II Histone Deacetylases. Validation Studies of the Inhibition of the Enzymatic Activity of HDAC4 by Small Molecules as a Novel Approach for Cancer Therapy

2009 · Jesus M. Ontoria, Sergio Altamura, et al. · Journal of Medicinal Chemistry · 64

Identification of substituted pyrazolo[1,5-a]quinazolin-5(4H)-one as potent poly(ADP-ribose)polymerase-1 (PARP-1) inhibitors

2009 · Federica Orvieto, Danila Branca, et al. · Bioorganic & Medicinal Chemistry Letters · 56

2-Trifluoroacetylthiophene oxadiazoles as potent and selective class II human histone deacetylase inhibitors

2008 · Ester Muraglia, Sergio Altamura, et al. · Bioorganic & Medicinal Chemistry Letters · 56

Design and Synthesis of Bicyclic Pyrimidinones as Potent and Orally Bioavailable HIV-1 Integrase Inhibitors

2008 · Ester Muraglia, Olaf Kinzel, et al. · Journal of Medicinal Chemistry · 53

Evolution, synthesis and SAR of tripeptide α-ketoacid Inhibitors of the hepatitis C virus NS3/NS4A serine protease

2002 · Stefania Colarusso, Benjamin Gerlach, et al. · Bioorganic & Medicinal Chemistry Letters · 53

Homolytic aromatic substitutions of pentatomic heteroaromatics with electrophilic carbon radicals generated by alkyl halides and triethylborane

1993 · Enrico Baciocchi, Ester Muraglia · Tetrahedron Letters · 47

Synthesis of γ-haloesters and γ-ketoesters by homolytic addition of carbon radicals generated by α-haloesters and triethylborane to alkenes and silyl enol ethers

1994 · Enrico Baciocchi, Ester Muraglia · Tetrahedron Letters · 41

Manganese(III)-promoted homolytic methylmalonylation of pyrrole and indole derivatives. A simple route to .alpha.-methyl-2-pyrrole- and .alpha.-methyl-3-indoleacetic acids

1993 · Enrico Baciocchi, Ester Muraglia · The Journal of Organic Chemistry · 35

Novel, potent phenethylamide inhibitors of the hepatitis C virus (HCV) NS3 protease: probing the role of P2 aryloxyprolines with hybrid structures

2003 · Federica Orvieto, Uwe Koch, et al. · Bioorganic & Medicinal Chemistry Letters · 30

Synthesis of perfluoroalkylpyrroles by homolytic substitution with perfluoroalkyl radicals

1993 · Enrico Baciocchi, Ester Muraglia · Tetrahedron Letters · 29

N-(2-alkylaminoethyl)-4-(1,2,4-oxadiazol-5-yl)piperazine-1-carboxamides as highly potent smoothened antagonists

2011 · Ester Muraglia, Jesus M. Ontoria, et al. · Bioorganic & Medicinal Chemistry Letters · 25

Discovery of N-[(1-aryl-1H-indazol-5-yl)methyl]amides derivatives as smoothened antagonists for inhibition of the hedgehog pathway

2009 · Gabriella Dessole, Danila Branca, et al. · Bioorganic & Medicinal Chemistry Letters · 25

Studies of the metabolic stability in cells of 5-(trifluoroacetyl)thiophene-2-carboxamides and identification of more stable class II histone deacetylase (HDAC) inhibitors

2008 · Rita Scarpelli, Annalise Di Marco, et al. · Bioorganic & Medicinal Chemistry Letters · 25

Identification and SAR of novel pyrrolo[1,2-a]pyrazin-1(2H)-one derivatives as inhibitors of poly(ADP-ribose) polymerase-1 (PARP-1)

2009 · Giovanna Pescatore, Danila Branca, et al. · Bioorganic & Medicinal Chemistry Letters · 21

Reactions of ferrocene and acetylferrocene with carbon-centered free radicals

1993 · Enrico Baciocchi, Barbara Floris, et al. · The Journal of Organic Chemistry · 21

Synthesis of a hexahydropyrimido[1,2-a]azepine-2-carboxamide derivative useful as an HIV integrase inhibitor

2007 · Marco Ferrara, Benedetta Crescenzi, et al. · Tetrahedron Letters · 20

Works count: 57

Citation count: 2,538

H-index: 22

I10-index: 35