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Tineke Vanderhaeghen

Observed name: Vanderhaeghen, Tineke
ORCID: 0000-0002-4227-2894
Observed ORCID: 0000-0002-4227-2894
OpenAlex ID: A5060906607
Combined glucocorticoid resistance and hyperlactatemia contributes to lethal shock in sepsis
2021 · Jolien Vandewalle, Steven Timmermans, et al. · Cell Metabolism · 78
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Hepatic PPARα function and lipid metabolic pathways are dysregulated in polymicrobial sepsis
2020 · Lise Van Wyngene, Tineke Vanderhaeghen, et al. · EMBO Molecular Medicine · 74
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TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile
2019 · Karen Dendoncker, Steven Timmermans, et al. · Proceedings of the National Academy of Sciences · 71
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Hypoxia‐inducible factors in metabolic reprogramming during sepsis
2020 · Tineke Vanderhaeghen, Jolien Vandewalle, et al. · FEBS Journal · 47
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Bidirectional Crosstalk Between Hypoxia Inducible Factors and Glucocorticoid Signalling in Health and Disease
2021 · Tineke Vanderhaeghen, Rudi Beyaert, et al. · Frontiers in Immunology · 33
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Paneth cell TNF signaling induces gut bacterial translocation and sepsis
2024 · Charlotte Wallaeys, Natalia Garcia-Gonzalez, et al. · Cell Host & Microbe · 28
Loss of PPARα function promotes epigenetic dysregulation of lipid homeostasis driving ferroptosis and pyroptosis lipotoxicity in metabolic dysfunction associated Steatotic liver disease (MASLD)
2024 · Claudia Theys, Tineke Vanderhaeghen, et al. · Frontiers in Molecular Medicine · 23
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Zinc inhibits lethal inflammatory shock by preventing microbe‐induced interferon signature in intestinal epithelium
2020 · Jolien Souffriau, Steven Timmermans, et al. · EMBO Molecular Medicine · 23
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A critical role for HNF4α in polymicrobial sepsis-associated metabolic reprogramming and death
2024 · Céline Van Dender, Steven Timmermans, et al. · EMBO Molecular Medicine · 18
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Reprogramming of glucocorticoid receptor function by hypoxia
2021 · Tineke Vanderhaeghen, Steven Timmermans, et al. · EMBO Reports · 17
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Glucocorticoids limit lipopolysaccharide‐induced lethal inflammation by a double control system
2020 · Kelly Van Looveren, Steven Timmermans, et al. · EMBO Reports · 15
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Hepatic Peroxisome Proliferator-Activated Receptor Alpha Dysfunction in Porcine Septic Shock
2022 · Jolien Vandewalle, Bruno Garcia, et al. · Cells · 12
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Point mutation I634A in the glucocorticoid receptor causes embryonic lethality by reduced ligand binding
2022 · Steven Timmermans, Nicolette J.D. Verhoog, et al. · Journal of Biological Chemistry · 12
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Crosstalk interactions between transcription factors ERRα and PPARα assist PPARα-mediated gene expression
2024 · Sofie J. Desmet, Jonathan Thommis, et al. · Molecular Metabolism · 11
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Comparative Analysis of Hepatic Gene Expression Profiles in Murine and Porcine Sepsis Models
2024 · Fëllanza Halimi, Tineke Vanderhaeghen, et al. · International Journal of Molecular Sciences · 7
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ZBTB32 performs crosstalk with the glucocorticoid receptor and is crucial in glucocorticoid responses to starvation
2021 · Lise Van Wyngene, Tineke Vanderhaeghen, et al. · iScience · 7
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Spns2/S1P: it takes two to tango with inflammation and metabolic rewiring during sepsis
2023 · Tineke Vanderhaeghen, Jolien Vandewalle, et al. · EMBO Reports · 3
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The impact of hepatocyte-specific deletion of hypoxia-inducible factors on the development of polymicrobial sepsis with focus on GR and PPARα function
2023 · Tineke Vanderhaeghen, Steven Timmermans, et al. · Frontiers in Immunology · 3
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Hypothalamic regulation of sepsis-associated anorexia: cytokine and hormonal signalling through AgRP/POMC circuits
2026 · Wanting Zhu, Claude Libert, et al. · EMBO Molecular Medicine · 2
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Turning a pathogen protein into a therapeutic tool for sepsis
2020 · Tineke Vanderhaeghen, Charlotte Wallaeys, et al. · EMBO Molecular Medicine · 2
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Taking the STING Out of Sepsis?
2020 · Jolien Vandewalle, Tineke Vanderhaeghen, et al. · Cell Host & Microbe · 2
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Using the inbred mouse strain SPRET/EiJ to provide novel insights in inflammation and infection research
2018 · Steven Timmermans, Jolien Souffriau, et al. · Mammalian Genome · 2
RXRα suppression drives hepatic metabolic and immune dysfunction in sepsis
2026 · Matyas Jelinek, Jolien Vandewalle, et al. · EMBO Molecular Medicine · 1
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Modulation of glucocorticoid receptor function under iron overload
2025 · Wanting Zhu, Tineke Vanderhaeghen, et al. · Frontiers in Immunology · 1
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From gatekeepers to regenerators: the plasticity of Paneth cells
2026 · Somara De Beul, Claude Libert, et al. · The EMBO Journal
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Works count: 32
Citation count: 492
H-index: 12
I10-index: 14
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