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Hajime Higuchi

Kupffer Cell Engulfment of Apoptotic Bodies Stimulates Death Ligand and Cytokine Expression
2003 · Ali Canbay, Ariel E. Feldstein, et al. · Hepatology · 470
Apoptotic Body Engulfment by a Human Stellate Cell Line Is Profibrogenic
2003 · Ali Canbay, Pavel Taimr, et al. · Laboratory Investigation · 419
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Imbalance in intestinal microflora constitution could be involved in the pathogenesis of inflammatory bowel disease
2007 · Hiromasa Takaishi, Takahiro Matsuki, et al. · International Journal of Medical Microbiology · 325
Diet associated hepatic steatosis sensitizes to Fas mediated liver injury in mice
2003 · Ariel E Feldstein, Ali Canbay, et al. · Journal of Hepatology · 320
Fas enhances fibrogenesis in the bile duct ligated mouse: A link between apoptosis and fibrosis
2002 · Ali Canbay, Hajime Higuchi, et al. · Gastroenterology · 305
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Increased expression of an inducible isoform of nitric oxide synthase and the formation of peroxynitrite in colonic mucosa of patients with active ulcerative colitis
1998 · H Kimura, R Hokari, et al. · Gut · 250
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Activated stellate cells express the TRAIL receptor-2/death receptor-5 and undergo TRAIL-mediated apoptosis
2003 · Pavel Taimr, Hajime Higuchi, et al. · Hepatology · 227
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Mcl-1 Mediates Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Resistance in Human Cholangiocarcinoma Cells
2004 · Makiko Taniai, Annette Grambihler, et al. · Cancer Research · 218
Cathepsin B inactivation attenuates hepatic injury and fibrosis during cholestasis
2003 · Ali Canbay, Maria Eugenia Guicciardi, et al. · Journal of Clinical Investigation · 193
Bile acids induce cyclooxygenase-2 expression via the epidermal growth factor receptor in a human cholangiocarcinoma cell line
2002 · Jung–Hwan Yoon, Hajime Higuchi, et al. · Gastroenterology · 193
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Cathepsin B inactivation attenuates hepatic injury and fibrosis during cholestasis
2003 · Ali Canbay, Maria Eugenia Guicciardi, et al. · Journal of Clinical Investigation · 188
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The Bile Acid Glycochenodeoxycholate Induces TRAIL-Receptor 2/DR5 Expression and Apoptosis
2001 · Hajime Higuchi, Steven F. Bronk, et al. · Journal of Biological Chemistry · 186
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Increased Nitric Oxide Production and Inducible Nitric Oxide Synthase Activity in Colonic Mucosa of Patients with Active Ulcerative Colitis and Crohn's Disease
1997 · Hiroyuki Kimura, Soichiro Miura, et al. · Digestive Diseases and Sciences · 164
Bile acids induce monocyte differentiation toward interleukin‐12 hypo‐producing dendritic cells via a TGR5‐dependent pathway
2012 · Riko Ichikawa, Tetsuro Takayama, et al. · Immunology · 163
Bile acids activate EGF receptor via a TGF-α-dependent mechanism in human cholangiocyte cell lines
2003 · Nathan W. Werneburg, Jung-Hwan Yoon, et al. · American Journal of Physiology-Gastrointestinal and Liver Physiology · 157
Mesenchymal stem cells regulate epithelial–mesenchymal transition and tumor progression of pancreatic cancer cells
2012 · Ayano Kabashima‐Niibe, Hajime Higuchi, et al. · Cancer Science · 149
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Bile Acids Up-regulate Death Receptor 5/TRAIL-receptor 2 Expression via a c-Jun N-terminal Kinase-dependent Pathway Involving Sp1
2003 · Hajime Higuchi, Annette Grambihler, et al. · Journal of Biological Chemistry · 143
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Nitric oxide inhibits apoptosis downstream of cytochrome C release by nitrosylating caspase 9.
2002 · Natalie J Török, Hajime Higuchi, et al. · PubMed · 139
Mechanisms of Liver Injury: An Overview
2003 · Hajime Higuchi, Gregory J. Gores · Current Molecular Medicine · 133
The Mitochondrial Permeability Transition Contributes to Acute Ethanol–Induced Apoptosis in Rat Hepatocytes
2001 · Hajime Higuchi, Masayuki Adachi, et al. · Hepatology · 131
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Side population of pancreatic cancer cells predominates in TGF‐β‐mediated epithelial to mesenchymal transition and invasion
2009 · Ayano Kabashima, Hajime Higuchi, et al. · International Journal of Cancer · 114
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Bile Acids Stimulate cFLIP Phosphorylation Enhancing TRAIL-mediated Apoptosis
2002 · Hajime Higuchi, Jung-Hwan Yoon, et al. · Journal of Biological Chemistry · 114
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IV. Bile acids and death receptors
2003 · Hajime Higuchi, Gregory J. Gores · American Journal of Physiology-Gastrointestinal and Liver Physiology · 112
Bax interacts with the voltage-dependent anion channel and mediates ethanol-induced apoptosis in rat hepatocytes
2004 · Masayuki Adachi, Hajime Higuchi, et al. · American Journal of Physiology-Gastrointestinal and Liver Physiology · 105
p16INK4a Promoter mutations are frequent in primary sclerosing cholangitis (PSC) and PSC-associated cholangiocarcinoma
2002 · Makiko Taniai, Hajime Higuchi, et al. · Gastroenterology · 93
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Works count: 132
Citation count: 6,776
H-index: 40
I10-index: 71
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