Author

Hamed Aissaoui

Observed names: Aissaoui, Hamed, H. Aissaoui

Institution: Idorsia Pharmaceuticals Ltd (Switzerland)

Observed institutions: University of Basel, Idorsia Pharmaceuticals Ltd (Switzerland), Actelion (Switzerland)

OpenAlex ID: A5061130041

Promotion of sleep by targeting the orexin system in rats, dogs and humans

2007 · Catherine Brisbare-Roch, Jasper Dingemanse, et al. · Nature Medicine · 578

On the Origin of the Low-Spin Character of Cytochrome P450cam in the Resting State—Investigations of Enzyme Models with Pulse EPR and ENDOR Spectroscopy

1998 · Hamed Aissaoui, Rainer Bachmann, et al. · Angewandte Chemie International Edition · 56

Structure–Activity Relationship, Biological, and Pharmacological Characterization of the Proline Sulfonamide ACT‐462206: a Potent, Brain‐Penetrant Dual Orexin 1/Orexin 2 Receptor Antagonist

2014 · Christoph Boss, Catherine Roch‐Brisbare, et al. · ChemMedChem · 42

Novel in vivo active anti-malarials based on a hydroxy-ethyl-amine scaffold

2012 · Claire-Lise Ciana, Romain Siegrist, et al. · Bioorganic & Medicinal Chemistry Letters · 42

Discovery of the Potent, Selective, Orally Available CXCR7 Antagonist ACT-1004-1239

2020 · Sylvia Richard-Bildstein, Hamed Aissaoui, et al. · Journal of Medicinal Chemistry · 41

Substituted pyrrolidin-2-ones: Centrally acting orexin receptor antagonists promoting sleep. Part 2

2015 · Thierry Sifferlen, Amandine Boller, et al. · Bioorganic & Medicinal Chemistry Letters · 34

Identification of a New Chemical Class of Antimalarials

2012 · Ralf Brunner, Hamed Aissaoui, et al. · The Journal of Infectious Diseases · 34

N-Glycine-sulfonamides as potent dual orexin 1/orexin 2 receptor antagonists

2008 · Hamed Aissaoui, Ralf Koberstein, et al. · Bioorganic & Medicinal Chemistry Letters · 29

Tetrahydroisoquinolines as Orexin Receptor Antagonists: Strategies for Lead Optimization by Solution-Phase Chemistry

2003 · Ralf Koberstein, Alexander Treiber, et al. · CHIMIA International Journal for Chemistry · 28

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Discovery and Characterization of ACT‐451840: an Antimalarial Drug with a Novel Mechanism of Action

2016 · Christoph Boss, Hamed Aissaoui, et al. · ChemMedChem · 27

Orexin Receptor Antagonism: A New Principle in Neuroscience

2008 · Christoph Boss, Catherine Brisbare-Roch, et al. · CHIMIA International Journal for Chemistry · 27

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Metabolism of the Dual Orexin Receptor Antagonist ACT-541468, Based on Microtracer/ Accelerator Mass Spectrometry

2019 · Clemens Muehlan, Hartmut Fischer, et al. · Current Drug Metabolism · 26

UV-triggered Affinity Capture Identifies Interactions between the Plasmodium falciparum Multidrug Resistance Protein 1 (PfMDR1) and Antimalarial Agents in Live Parasitized Cells

2013 · Ralf Brunner, Caroline L. Ng, et al. · Journal of Biological Chemistry · 23

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Discovery of substituted lactams as novel dual orexin receptor antagonists. Synthesis, preliminary structure–activity relationship studies and efforts towards improved metabolic stability and pharmacokinetic properties. Part 1

2014 · Thierry Sifferlen, Amandine Boller, et al. · Bioorganic & Medicinal Chemistry Letters · 18

Novel pyrazolo-tetrahydropyridines as potent orexin receptor antagonists

2010 · Thierry Sifferlen, Christoph Boss, et al. · Bioorganic & Medicinal Chemistry Letters · 17

The synthesis of a new active-site analogue of cytochrome P450 carrying substrate recognition sites and athiolate ligand

1996 · Hamed Aissaoui, Sandro Ghirlanda, et al. · Journal of Molecular Catalysis A Chemical · 16

Discovery of the Clinical Candidate IDOR-1117-2520: A Potent and Selective Antagonist of CCR6 for Autoimmune Diseases

2024 · Emmanuel A. Meyer, Andrew L. Croxford, et al. · Journal of Medicinal Chemistry · 10

Zum Problem des Low-spin-Charakters von Cytochrom P450cam im „Resting State“ – Untersuchungen von Enzymmodellen mit Puls-EPR- und ENDOR-Spektroskopie

1998 · Hamed Aissaoui, Rainer Bachmann, et al. · Angewandte Chemie · 9

CYP3A4 Catalyzes the Rearrangement of the Dual Orexin Receptor Antagonist Daridorexant to 4‐Hydroxypiperidinol Metabolites

2023 · Alexander Treiber, Hamed Aissaoui, et al. · ChemMedChem · 8

Discovery, synthesis and SAR of 2-acyl-1-biarylmethyl pyrazolidines, dual orexin receptor antagonists designed as fast and short-acting sleeping drugs

2024 · Jean-Philippe Surivet, Melanie Kessler, et al. · Bioorganic & Medicinal Chemistry · 6

Design, Synthesis, and Optimization of Indole Acetic Acid Derivatives as Potent and Selective CRTH2 Receptor Antagonists: Discovery of ACT‐774312

2023 · Hamed Aissaoui, Martin Holdener, et al. · ChemMedChem · 4

The orexin 1-selective receptor antagonist nivasorexant is a time-dependent inhibitor of CYP2C19 and CYP3A4

2025 · Alexander Treiber, Fabienne Drouet, et al. · Xenobiotica · 1

Back Cover: Discovery and Characterization of ACT‐451840: an Antimalarial Drug with a Novel Mechanism of Action (ChemMedChem 18/2016)

2016 · Christoph Boss, Hamed Aissaoui, et al. · ChemMedChem · 1

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Tetrahydroisoquinolines as Orexin Receptor Antagonists: Strategies for Lead Optimization by Solution‐Phase Chemistry

2004 · Ralf Koberstein, Hamed Aissaoui, et al. · ChemInform · 1

Discovery of CCR8 Antagonist IDOR‐1136‐5177 for the Treatment of Cancer

2025 · Stefan Diethelm, Luboš Remeň, et al. · ChemMedChem

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Works count: 34

Citation count: 1,078

H-index: 16

I10-index: 17