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Werner L. Neidhart

Observed names: Neidhart, W., Neidhart, Werner, W Neidhart, W. NEIDHART, W. Neidhart, Werner Neidhart
OpenAlex ID: A5061147310
“Scaffold-Hopping” by Topological Pharmacophore Search: A Contribution to Virtual Screening
1999 · Gisbert Schneider, Werner Neidhart, et al. · Angewandte Chemie International Edition · 715
Pharmacological characterization of bosentan, a new potent orally active nonpeptide endothelin receptor antagonist.
1994 · M Clozel, V Breu, et al. · Journal of Pharmacology and Experimental Therapeutics · 664
Pathophysiological role of endothelin revealed by the first orally active endothelin receptor antagonist
1993 · Martine Clozel, Volker Breu, et al. · Nature · 513
Development of a Virtual Screening Method for Identification of “Frequent Hitters” in Compound Libraries
2001 · Olivier Roche, Petra Schneider, et al. · Journal of Medicinal Chemistry · 249
A Real-World Perspective on Molecular Design
2016 · Bernd Kuhn, Wolfgang Guba, et al. · Journal of Medicinal Chemistry · 116
Ro 61–1790, a New Hydrosoluble Endothelin Antagonist: General Pharmacology and Effects on Experimental Cerebral Vasospasm
1997 · Sébastien Roux, Volker Breu, et al. · Journal of Pharmacology and Experimental Therapeutics · 115
Virtual Screening for Bioactive Molecules by Evolutionary De Novo Design
2000 · Gisbert Schneider, Odile Clément-Chomienne, et al. · Angewandte Chemie International Edition · 103
Ro 42-5892 is a potent orally active renin inhibitor in primates.
1991 · W Fischli, J P Clozel, et al. · Hypertension · 100
„Grundgerüstwechsel“ (Scaffold-Hopping) durch topologische Pharmakophorsuche: ein Beitrag zum virtuellen Screening
1999 · Gisbert Schneider, Werner Neidhart, et al. · Angewandte Chemie · 52
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In vitro characterisation of Ro 46‐8443, the first non‐peptide antagonist selective for the endothelin ETB receptor
1996 · Volker Breu, Martine Clozel, et al. · FEBS Letters · 44
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Benzodioxoles: Novel Cannabinoid-1 Receptor Inverse Agonists for the Treatment of Obesity
2008 · Leo Alig, Jochem Alsenz, et al. · Journal of Medicinal Chemistry · 43
Novel and potent NPY5 receptor antagonists derived from virtual screening and iterative parallel chemistry design
2005 · Wolfgang Guba, Werner Neidhart, et al. · Bioorganic & Medicinal Chemistry Letters · 37
Discovery of Ro 48-5695: A potent mixed endothelin receptor antagonist optimized from bosentan
1997 · Werner Neidhart, Volker Breu, et al. · Bioorganic & Medicinal Chemistry Letters · 33
Discovery of RO7185876, a Highly Potent γ-Secretase Modulator (GSM) as a Potential Treatment for Alzheimer’s Disease
2020 · Hasane Ratni, Andre Alker, et al. · ACS Medicinal Chemistry Letters · 32
Design and synthesis of selective, dual fatty acid binding protein 4 and 5 inhibitors
2016 · Holger Kühne, Ulrike Obst-Sander, et al. · Bioorganic & Medicinal Chemistry Letters · 28
The Discovery of Nonpeptide Endothelin Receptor Antagonists. Progression towards Bosentan
1996 · Werner Neidhart, Volker Breu, et al. · CHIMIA International Journal for Chemistry · 26
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Photoswitch dissociation from a G protein-coupled receptor resolved by time-resolved serial crystallography
2024 · Hannah Glover, Torben Saßmannshausen, et al. · Nature Communications · 25
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Stepwise Design of γ‑Secretase Modulators with an Advanced Profile by Judicious Coordinated Structural Replacements and an Unconventional Phenyl Ring Bioisostere
2020 · Rosa María Rodríguez Sarmiento, Caterina Bissantz, et al. · Journal of Medicinal Chemistry · 24
Establishment of robust functional assays for the characterization of neuropeptide Y (NPY) receptors: identification of 3-(5-benzoyl-thiazol-2-ylamino)-benzonitrile as selective NPY type 5 receptor antagonist
2005 · Frank M. Dautzenberg, Jacqueline Higelin, et al. · Neuropharmacology · 16
Kinetic Basis for the Design of Azobenzene-Based Photoswitchable A 2a Adenosine Receptor Ligands
2024 · Torben Saßmannshausen, Hannah Glover, et al. · Journal of the American Chemical Society · 15
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Isomeric thiazole derivatives as ligands for the neuropeptide Y5 receptor
2005 · Matthias Nettekoven, Wolfgang Guba, et al. · Bioorganic & Medicinal Chemistry Letters · 15
Aminothiazole Derivatives as Neuropeptide Y5 Receptor Ligands: Finding the Balance between Affinity and Physicochemical Properties
2005 · Matthias Nettekoven, Wolfgang Guba, et al. · ChemMedChem · 12
Synthesis of (11S)- and (11R)-[11-2H1]porphobilinogen; stereochemical studies on hydroxymethylbilane synthase (PBG deaminase)
1985 · Werner Neidhart, Paul C. Anderson, et al. · Journal of the Chemical Society Chemical Communications · 11
Channels and Transporters
2010 · Raimund Dutzler, Beat Ernst, et al. · CHIMIA International Journal for Chemistry · 6
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Evolutionäres De-novo-Design bioaktiver Moleküle: ein Ansatz zum virtuellen Screening
2000 · Gisbert Schneider, Odile Clément-Chomienne, et al. · Angewandte Chemie · 6
Works count: 43
Citation count: 3,016
H-index: 18
I10-index: 23
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