Get started
Author

Lee R. Silverman

An Inhibitor of Mutant IDH1 Delays Growth and Promotes Differentiation of Glioma Cells
2013 · Dan Rohle, Janeta Popovici-Muller, et al. · Science · 1,148
AG-221, a First-in-Class Therapy Targeting Acute Myeloid Leukemia Harboring Oncogenic IDH2 Mutations
2017 · Katharine Yen, Jeremy Travins, et al. · Cancer Discovery · 472
Discovery of AG-120 (Ivosidenib): A First-in-Class Mutant IDH1 Inhibitor for the Treatment of IDH1 Mutant Cancers
2018 · Janeta Popovici-Muller, Rene? M. Lemieux, et al. · ACS Medicinal Chemistry Letters · 457
Characterization of Alisertib (MLN8237), an Investigational Small-Molecule Inhibitor of Aurora A Kinase Using Novel In Vivo Pharmacodynamic Assays
2011 · Mark G. Manfredi, Jeffrey A. Ecsedy, et al. · Clinical Cancer Research · 300
AG-348 enhances pyruvate kinase activity in red blood cells from patients with pyruvate kinase deficiency
2017 · Charles Kung, Jeff Hixon, et al. · Blood · 133
Neurophysiological, histological and immunohistochemical characterization of bortezomib-induced neuropathy in mice
2010 · Jordi Bruna, Esther Udina, et al. · Experimental Neurology · 102
Human T-Cell Lymphotropic Virus Type 1 Open Reading Frame II-Encoded p30 II Is Required for In Vivo Replication: Evidence of In Vivo Reversion
2004 · Lee R. Silverman, Andrew J. Phipps, et al. · Journal of Virology · 84
A Critical Review of the Effectiveness of Rodent Pharmaceutical Carcinogenesis Testing in Predicting for Human Risk
2011 · C. L. Alden, A. Lynn, et al. · Veterinary Pathology · 69
PDF
Animal models for human T-lymphotropic virus type 1 (HTLV-1) infection and transformation
2005 · Michael D Lairmore, Lee Silverman, et al. · Oncogene · 68
HTLV-1 Rex is required for viral spread and persistence in vivo but is dispensable for cellular immortalization in vitro
2003 · Jianxin Ye, Lee Silverman, et al. · Blood · 63
Phase 1 Single‐ and Multiple‐Ascending‐Dose Randomized Studies of the Safety, Pharmacokinetics, and Pharmacodynamics of AG‐348, a First‐in‐Class Allosteric Activator of Pyruvate Kinase R, in Healthy Volunteers
2018 · Hua Yang, Elizabeth Merica, et al. · Clinical Pharmacology in Drug Development · 58
Phase I Assessment of New Mechanism-Based Pharmacodynamic Biomarkers for MLN8054, a Small-Molecule Inhibitor of Aurora A Kinase
2010 · Arijit Chakravarty, Vaishali Shinde, et al. · Cancer Research · 49
PDF
A mouse model of a human congenital disorder of glycosylation caused by loss of PMM2
2016 · Barden Chan, Michelle Clasquin, et al. · Human Molecular Genetics · 47
Human T-lymphotropic virus type-1 p30 alters cell cycle G2 regulation of T lymphocytes to enhance cell survival
2007 · Antara Datta, Lee Silverman, et al. · Retrovirology · 44
PDF
Cyclooxygenase-2 Expression in the Cornea of Dogs with Keratitis
2004 · R. S. Sellers, L. Silverman, et al. · Veterinary Pathology · 22
Preclinical toxicology profile of squalene epoxidase inhibitors
2020 · Raj Nagaraja, Andrew Olaharski, et al. · Toxicology and Applied Pharmacology · 21
Predictive Toxicology Approaches for Small Molecule Oncology Drugs
2010 · T. Maziasz, V.J. Kadambi, et al. · Toxicologic Pathology · 19
PDF
MLN8237: an orally active small molecule inhibitor of Aurora A kinase in phase I clinical trials
2008 · Todd B. Sells, Jeffrey Ecsedy, et al. · Cancer Research · 18
Enhanced expression of Cyclooxygenase‐2 in glaucomatous dog eyes
2004 · Janene L. Marshall, Kristina M. Stanfield, et al. · Veterinary Ophthalmology · 18
Abstract B126: AG-881, a brain penetrant, potent, pan-mutant IDH (mIDH) inhibitor for use in mIDH solid and hematologic malignancies
2018 · Katharine Yen, Zenon Konteatis, et al. · Molecular Cancer Therapeutics · 17
Effect of Proteasome Inhibitors With Different Chemical Structures on the Ubiquitin–Proteasome System In Vitro
2010 · V. Csizmadia, E. Csizmadia, et al. · Veterinary Pathology · 17
A small molecule inhibitor of mutant IDH2 rescues cardiomyopathy in a D‐2‐hydroxyglutaric aciduria type II mouse model
2016 · Fang Wang, Jeremy Travins, et al. · Journal of Inherited Metabolic Disease · 16
PDF
Industry–Contract Research Organization Pathology Interactions
2011 · Sylvie J. Gosselin, Bernard Palate, et al. · Toxicologic Pathology · 15
In vivo analysis of replication and immunogenicity of proviral clones of human T-lymphotropic virus type 1 with selective envelope surface-unit mutations
2005 · Lee R. Silverman, Andrew J. Phipps, et al. · Blood · 11
Proteasome Inhibitor Associated Neuropathy Is Mechanism Based
2008 · Lee Silverman, Vilmos Csizmadia, et al. · Blood · 9
Works count: 68
Citation count: 3,314
H-index: 18
I10-index: 24
Year
Topic
Type