Author

Terrence E. O’Brien

Observed names: T. E. O'Brien, Terrence E. O'Brien, Terrence E. O?Brien, Terrence Edward O’Brien, Terrence O'Brien

Institution: Numerion Labs (United States)

Observed institutions: Genentech, Numerion Labs (United States), San Francisco State University, University of California, Davis

ORCID: 0000-0002-5621-5065

Observed ORCID: 0000-0002-5621-5065

OpenAlex ID: A5061622066

AI is a viable alternative to high throughput screening: a 318-target study

2024 · The Atomwise AIMS Program, Izhar Wallach, et al. · Scientific Reports · 137

Comparison of Small Molecule Inhibitors of the Bacterial Cell Division Protein FtsZ and Identification of a Reliable Cross-Species Inhibitor

2012 · David E. Anderson, Michelle B. Kim, et al. · ACS Chemical Biology · 80

Predicting Productive Binding Modes for Substrates and Carbocation Intermediates in Terpene Synthases—Bornyl Diphosphate Synthase As a Representative Case

2018 · Terrence E. O’Brien, Steven J. Bertolani, et al. · ACS Catalysis · 56

Mechanistically informed predictions of binding modes for carbocation intermediates of a sesquiterpene synthase reaction

2016 · T. E. O'Brien, S. J. Bertolani, et al. · Chemical Science · 56

PDF

Synthesis and Evaluation of Quinazolines as Inhibitors of the Bacterial Cell Division Protein FtsZ

2015 · Gabriella M. Nepomuceno, Katie M. Chan, et al. · ACS Medicinal Chemistry Letters · 39

PDF

Biosynthesis of the microtubule-destabilizing diterpene pseudolaric acid B from golden larch involves an unusual diterpene synthase

2017 · Sibongile Mafu, Prema Sambandaswami Karunanithi, et al. · Proceedings of the National Academy of Sciences · 30

PDF

Computer-Aided Drug Design for Undergraduates

2019 · Dean J. Tantillo, Justin B. Siegel, et al. · Journal of Chemical Education · 25

The Synthesis and Antimicrobial Activity of Heterocyclic Derivatives of Totarol

2012 · Michelle B. Kim, Terrence E. O'Brien, et al. · ACS Medicinal Chemistry Letters · 25

Synthesis of aryl-heteroaryl ureas (AHUs) based on 4-aminoquinoline and their evaluation against the insulin-like growth factor receptor (IGF-1R)

2010 · William Engen, Terrence E. O’Brien, et al. · Bioorganic & Medicinal Chemistry · 23

Discovery of Novel Trace Amine-Associated Receptor 5 (TAAR5) Antagonists Using a Deep Convolutional Neural Network

2022 · Carlotta Bon, Ting-Rong Chern, et al. · International Journal of Molecular Sciences · 22

PDF

Changing Face: A Key Residue for the Addition of Water by Sclareol Synthase

2018 · Meirong Jia, Terrence E. O’Brien, et al. · ACS Catalysis · 21

Elucidating Substrate Promiscuity within the FabI Enzyme Family

2017 · Gabriel S. Freund, Terrence E. O’Brien, et al. · ACS Chemical Biology · 21

Crystal Structure and Mechanistic Molecular Modeling Studies of Mycobacterium tuberculosis Diterpene Cyclase Rv3377c

2020 · Yue Zhang, Lisa M. Prach, et al. · Biochemistry · 17

Docking carbocations into terpene synthase active sites using chemically meaningful constraints—The TerDockin approach

2024 · Ian S. Torrence, Terrence E. O’Brien, et al. · Methods in enzymology on CD-ROM/Methods in enzymology · 8

Systematic Functional Analysis of Active-Site Residues in l -Threonine Dehydrogenase from Thermoplasma volcanium

2017 · Morgan Desjardins, Wai Shun Mak, et al. · ACS Omega · 7

Efficient identification of new small molecules targeting succinate dehydrogenase in non-small cell lung cancer

2025 · Luis Silva, Nicholas Skiados, et al. · Cancer Cell International · 4

PDF

Author Correction: AI is a viable alternative to high throughput screening: a 318-target study

2024 · The Atomwise AIMS Program, Izhar Wallach, et al. · Scientific Reports · 3

PDF

Identification of compounds that repress DUX4 expression in facioscapulohumeral muscular dystrophy

2026 · Ning Chang, Hannah P. Moore, et al. · Scientific Reports · 1

PDF

Screening for novel chemical scaffolds targeting PCNA identifies the Hsp90alpha inhibitor SNX-2112

2026 · Jennifer Jossart, Ning Ma, et al. · Current Research in Structural Biology · 1

Hybrid Quantum Mechanics/Rosetta Modeling Mechanistic Study of a Terpene Synthase

2020 · Sophie R. Shoemaker, Yue Zhang, et al. · Biophysical Journal · 1

PDF

Abstract 1811: Efficient identification of new small molecules targeting succinate dehydrogenase in non-small cell lung cancer

2024 · Luis Silva, Nicholas Skiados, et al. · Cancer Research

Binding site elucidation of a small molecule inhibitor of FtsZ

2013 · Gabriella M. Nepomuceno, David E. Anderson, et al. · Brazilian Meeting on Organic Synthesis (BMOS)

PDF

Works count: 22

Citation count: 577

H-index: 13

I10-index: 13