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Author

Ashleigh S. Paparella

Observed name: Ashleigh Paparella
ORCID: 0000-0003-1816-1286
Observed ORCID: 0000-0003-1816-1286
OpenAlex ID: A5062641075
AI is a viable alternative to high throughput screening: a 318-target study
2024 · The Atomwise AIMS Program, Izhar Wallach, et al. · Scientific Reports · 149
Biotin Protein Ligase Is a Target for New Antibacterials
2016 · Jiage Feng, Ashleigh Paparella, et al. · Antibiotics · 35
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Inhibition of Clostridium difficile TcdA and TcdB toxins with transition state analogues
2021 · Ashleigh S. Paparella, Briana L. Aboulache, et al. · Nature Communications · 34
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Halogenation of Biotin Protein Ligase Inhibitors Improves Whole Cell Activity against Staphylococcus aureus
2017 · Ashleigh S. Paparella, Kwang Jun Lee, et al. · ACS Infectious Diseases · 32
Structure Guided Design of Biotin Protein Ligase Inhibitors for Antibiotic Discovery
2013 · Ashleigh Paparella, Tatiana Soares da Costa, et al. · Current Topics in Medicinal Chemistry · 29
Heterocyclic acyl-phosphate bioisostere-based inhibitors of Staphylococcus aureus biotin protein ligase
2014 · William Tieu, Angie M. Jarrad, et al. · Bioorganic & Medicinal Chemistry Letters · 25
Clostridioides difficile TcdB Toxin Glucosylates Rho GTPase by an SNi Mechanism and Ion Pair Transition State
2022 · Ashleigh S. Paparella, Sean M. Cahill, et al. · ACS Chemical Biology · 20
Improved Synthesis of Biotinol-5′-AMP: Implications for Antibacterial Discovery
2014 · William Tieu, Steven W. Polyak, et al. · ACS Medicinal Chemistry Letters · 18
New Series of BPL Inhibitors To Probe the Ribose-Binding Pocket of Staphylococcus aureus Biotin Protein Ligase
2016 · Jiage Feng, Ashleigh S. Paparella, et al. · ACS Medicinal Chemistry Letters · 15
Sulfonamide-Based Inhibitors of Biotin Protein Ligase as New Antibiotic Leads
2019 · Kwang Jun Lee, William Tieu, et al. · ACS Chemical Biology · 11
Advanced Resistance Studies Identify Two Discrete Mechanisms in Staphylococcus aureus to Overcome Antibacterial Compounds that Target Biotin Protein Ligase
2020 · Andrew J. Hayes, Jiulia Satiaputra, et al. · Antibiotics · 8
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Isofagomine Inhibits Multiple TcdB Variants and Protects Mice from Clostridioides difficile-Induced Mortality
2024 · Ashleigh S. Paparella, Isabella Brew, et al. · ACS Infectious Diseases · 4
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A template guided approach to generating cell permeable inhibitors of Staphylococcus aureus biotin protein ligase
2017 · Ashleigh S. Paparella, Jiage Feng, et al. · Tetrahedron · 4
Author Correction: AI is a viable alternative to high throughput screening: a 318-target study
2024 · The Atomwise AIMS Program, Izhar Wallach, et al. · Scientific Reports · 3
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Broom fibre PRB for heavy metals groundwater remediation
2009 · Agnese Molinari, Salvatore Troisi, et al. · The EGU General Assembly · 2
First inhibitor of a bacterial two-partner secretion system
2026 · Alfred Hartojo, Laurence Don Wai Luu, et al. · bioRxiv (Cold Spring Harbor Laboratory) · 1
Isofagomine Derivatives as TcdB Glucosyltransferase Inhibitors
2026 · Karl J. Shaffer, Nord Gilaj, et al. · Journal of Medicinal Chemistry
Contributors
2025 · Olga Abian, Shahbaz Ahmed, et al. · Elsevier eBooks
Thermodynamics of transition state analogs
2025 · Vern L. Schramm, Ashleigh S. Paparella · Elsevier eBooks
Characterization and development of new anti‐toxins targeting Clostridium difficile
2021 · Ashleigh Paparella, Briana Aboulache, et al. · The FASEB Journal
Development of biotin protein ligase inhibitors as new antibiotics to treat Staphylococcus aureus
2017 · Ashleigh S. Paparella · Adelaide Research & Scholarship (AR&S) (University of Adelaide)
Rapid and simple detection of Legionella pneumophila in old network potable water by polimerase chain reaction. A comparison with a common microbiologic detection method
2005 · Ashleigh S. Paparella, F. Schiavon, et al.
Works count: 22
Citation count: 390
H-index: 10
I10-index: 10
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