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Christopher H. Douse

Observed names: Christopher Douse, Christopher H Douse
Institution: Lund University
ORCID: 0000-0002-1604-8944
Observed ORCID: 0000-0002-1604-8944
OpenAlex ID: A5062661954
Hyperactivation of HUSH complex function by Charcot–Marie–Tooth disease mutation in MORC2
2017 · Iva A Tchasovnikarova, Richard T Timms, et al. · Nature Genetics · 182
TASOR is a pseudo-PARP that directs HUSH complex assembly and epigenetic transposon control
2020 · Christopher H. Douse, Iva A. Tchasovnikarova, et al. · Nature Communications · 114
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Neuropathic MORC2 mutations perturb GHKL ATPase dimerization dynamics and epigenetic silencing by multiple structural mechanisms
2018 · Christopher H. Douse, Stuart Bloor, et al. · Nature Communications · 103
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LINE-1 retrotransposons drive human neuronal transcriptome complexity and functional diversification
2023 · Raquel Garza, Diahann Atacho, et al. · Science Advances · 88
A cis-acting structural variation at the ZNF558 locus controls a gene regulatory network in human brain development
2021 · Pia A. Johansson, Per Ludvik Brattås, et al. · Cell stem cell · 64
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Crystal Structures of Stapled and Hydrogen Bond Surrogate Peptides Targeting a Fully Buried Protein–Helix Interaction
2014 · Christopher H. Douse, Sabrina J. Maas, et al. · ACS Chemical Biology · 57
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Structure and functional mapping of the KRAB‐KAP1 repressor complex
2022 · Guido A. Stoll, Ninoslav Pandiloski, et al. · The EMBO Journal · 51
Periphilin self-association underpins epigenetic silencing by the HUSH complex
2020 · Daniil M Prigozhin, Christopher H Douse, et al. · Nucleic Acids Research · 39
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Structure–function analysis reveals that the Pseudomonas aeruginosa Tps4 two‐partner secretion system is involved in CupB5 translocation
2015 · James A. Garnett, Daniela Muhl, et al. · Protein Science · 36
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The annotation of GBA1 has been concealed by its protein-coding pseudogene GBAP1
2024 · Emil K. Gustavsson, Siddharth Sethi, et al. · Science Advances · 35
The Plasmodium Class XIV Myosin, MyoB, Has a Distinct Subcellular Location in Invasive and Motile Stages of the Malaria Parasite and an Unusual Light Chain
2015 · Noor A. Yusuf, Judith L. Green, et al. · Journal of Biological Chemistry · 35
LINE-1 retrotransposons mediate cis-acting transcriptional control in human pluripotent stem cells and regulate early brain development
2025 · Anita Adami, Raquel Garza, et al. · Cell Genomics · 30
Regulation of the Plasmodium Motor Complex
2012 · Christopher H. Douse, Judith L. Green, et al. · Journal of Biological Chemistry · 30
Mini-heterochromatin domains constrain the cis-regulatory impact of SVA transposons in human brain development and disease
2024 · Vivien Horváth, Raquel Garza, et al. · Nature Structural & Molecular Biology · 25
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DNA methylation governs the sensitivity of repeats to restriction by the HUSH-MORC2 corepressor
2024 · Ninoslav Pandiloski, Vivien Horváth, et al. · Nature Communications · 24
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Targeting a Dynamic Protein–Protein Interaction: Fragment Screening against the Malaria Myosin A Motor Complex
2014 · Christopher H. Douse, Nina Vrielink, et al. · ChemMedChem · 24
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Transposable element DNA and RNA: Drivers of gene expression, evolution, and disease
2026 · Jessica Sook Yuin Ho, Christopher H. Douse, et al. · Cell · 9
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Crystal structure and biochemical activity of the macrodomain from rubella virus p150
2024 · Guido A. Stoll, Nikos Nikolopoulos, et al. · Journal of Virology · 6
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Loss of SETDB1-mediated H3K9me3 in human neural progenitor cells leads to transcriptional activation of L1 retrotransposons
2026 · Ofelia Karlsson, Ninoslav Pandiloski, et al. · Nucleic Acids Research · 3
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Protocol for efficient CRISPRi-mediated silencing of retrotransposons in human pluripotent stem cells
2026 · Anita Adami, Raquel Garza, et al. · STAR Protocols · 2
Retroviral insertions contributed to the divergence of human and chimpanzee brains
2026 · Patricia Gerdes, Ofelia Karlsson, et al. · Science Advances · 1
MORC2 directs transcription-dependent CpG methylation of human LINE-1 transposons in early neurodevelopment
2025 · Fereshteh Dorazehi, Caterina Francesconi, et al. · bioRxiv (Cold Spring Harbor Laboratory) · 1
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De novo missense variants in TRIM28 identified in individuals with neurodevelopmental delay show features of transposable element activation
2026 · Laura Castilla-Vallmanya, Ninoslav Pandiloski, et al. · bioRxiv (Cold Spring Harbor Laboratory)
Works count: 23
Citation count: 959
H-index: 16
I10-index: 16
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