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Mireille Krier
Observed names:
Krier, M.,
Krier, Mireille
Institution:
OpenEye (Sweden)
Observed institutions:
Centre National de la Recherche Scientifique,
Merck KGaA, Darmstadt (Germany),
OpenEye (Sweden),
Merck Healthcare KGaA, Darmstadt (Germany),
Universidade Federal de Alagoas
ORCID:
0000-0003-4912-2925
Observed ORCID:
0000-0003-4912-2925
OpenAlex ID:
A5062799024
Large-Scale Assessment of Binding Free Energy Calculations in Active Drug Discovery Projects
2020
·
Christina E. M. Schindler
, Hannah Baumann
, et al.
·
Journal of Chemical Information and Modeling
·
310
Assessing the Scaffold Diversity of Screening Libraries
2006
·
Mireille Krier
, Guillaume Bret
, et al.
·
Journal of Chemical Information and Modeling
·
121
Fragment-Based Discovery of New Highly Substituted 1H-Pyrrolo[2,3-b]- and 3H-Imidazolo[4,5-b]-Pyridines as Focal Adhesion Kinase Inhibitors
2013
·
Timo Heinrich
, Jeyaprakashnarayanan Seenisamy
, et al.
·
Journal of Medicinal Chemistry
·
78
Design of Small-Sized Libraries by Combinatorial Assembly of Linkers and Functional Groups to a Given Scaffold: Application to the Structure-Based Optimization of a Phosphodiesterase 4 Inhibitor
2005
·
Mireille Krier
, João X. de Araújo-Júnior
, et al.
·
Journal of Medicinal Chemistry
·
60
Fragment-based discovery of focal adhesion kinase inhibitors
2013
·
Ulrich Grädler
, Jörg Bomke
, et al.
·
Bioorganic & Medicinal Chemistry Letters
·
37
Novel reversible methionine aminopeptidase-2 (MetAP-2) inhibitors based on purine and related bicyclic templates
2016
·
Timo Heinrich
, Hans-Peter Buchstaller
, et al.
·
Bioorganic & Medicinal Chemistry Letters
·
28
Discovery of 5-{2-[5-Chloro-2-(5-ethoxyquinoline-8-sulfonamido)phenyl]ethynyl}-4-methoxypyridine-2-carboxylic Acid, a Highly Selective in Vivo Useable Chemical Probe to Dissect MCT4 Biology
2021
·
Timo Heinrich
, Ada Sala-Hojman
, et al.
·
Journal of Medicinal Chemistry
·
24
Avoiding hERG-liability in drug design via synergetic combinations of different (Q)SAR methodologies and data sources: a case study in an industrial setting
2019
·
Thierry Hanser
, Fabian P. Steinmetz
, et al.
·
Journal of Cheminformatics
·
21
PDF
Design and synthesis of isoquinolines and benzimidazoles as RAF kinase inhibitors
2011
·
Hans-Peter Buchstaller
, Lars Burgdorf
, et al.
·
Bioorganic & Medicinal Chemistry Letters
·
20
Atropisomerism – A Neglected Way to Escape Out of Solubility Flatlands
2021
·
Christoph Saal
, Axel Becker
, et al.
·
Journal of Pharmaceutical Sciences
·
17
Discovery of Cycloalkyl[c]thiophenes as Novel Scaffolds for Hypoxia-Inducible Factor-2α Inhibitors
2023
·
Hans-Peter Buchstaller
, Ada Sala-Hojman
, et al.
·
Journal of Medicinal Chemistry
·
11
Abstract DDT02-01: First-time disclosure of M3258: A selective inhibitor of the immunoproteasome subunit LMP7 with potential for improved therapeutic utility in multiple myeloma compared to pan-proteasome inhibitors
2019
·
Michael Sanderson
, Michael Busch
, et al.
·
Cancer Research
·
9
Vibrational circular dichroism studies of exceptionally strong chirality inducers in liquid crystals
2021
·
Mark A. J. Koenis
, Valentin P. Nicu
, et al.
·
Physical Chemistry Chemical Physics
·
8
PDF
Pharmacophore alignment search tool: Influence of canonical atom labeling on similarity searching
2010
·
Volker Hähnke
, Matthias Rupp
, et al.
·
Journal of Computational Chemistry
·
8
Abstract LB-054: Discovery and profiling of M3258, a potent and selective LMP7 inhibitor demonstrating high efficacy in multiple myeloma models
2019
·
Markus Klein
, Michael Busch
, et al.
·
Cancer Research
·
6
Synthesis and crystal structure of rac-2-(1,3-dioxoisoindolin-2-yl)ethyl 4-methyl-N-phenyl-N′-(triisopropylsilyl)benzenesulfondiimidoate: the first member of a new substance class
2022
·
Erik Friedrich
, Timo Heinrich
, et al.
·
Acta Crystallographica Section E Crystallographic Communications
·
2
PDF
Abstract DDT02-01: First-time disclosure of M3258: A selective inhibitor of the immunoproteasome subunit LMP7 with potential for improved therapeutic utility in multiple myeloma compared to pan-proteasome inhibitors
2019
·
Michael Sanderson
, Michael Busch
, et al.
·
Molecular and Cellular Biology / Genetics
·
2
Abstract LB-054: Discovery and profiling of M3258, a potent and selective LMP7 inhibitor demonstrating high efficacy in multiple myeloma models
2019
·
Markus Klein
, Michael Busch
, et al.
·
Cancer Chemistry
·
2
SCOPE: From Shape and Color to Binding Affinity, with Confidence
2026
·
Jingyi Chen
, Chris Neale
, et al.
·
Research Square
PDF
Strategic Key Performance Indicators for AI in Lead Optimization
2026
·
Theodor Theis
, Stefanie Flohr
, et al.
·
ChemMedChem
CCDC 2150876: Experimental Crystal Structure Determination
2023
·
Buchstaller, Hans-Peter
, Sala-Hojman, Ada
, et al.
·
The Cambridge Structural Database
CCDC 2240817: Experimental Crystal Structure Determination
2023
·
Buchstaller, Hans-Peter
, Sala-Hojman, Ada
, et al.
·
The Cambridge Structural Database
CCDC 2257778: Experimental Crystal Structure Determination
2023
·
Buchstaller, Hans-Peter
, Sala-Hojman, Ada
, et al.
·
The Cambridge Structural Database
CCDC 2257777: Experimental Crystal Structure Determination
2023
·
Buchstaller, Hans-Peter
, Sala-Hojman, Ada
, et al.
·
The Cambridge Structural Database
CCDC 2163661: Experimental Crystal Structure Determination
2022
·
Friedrich, E.
, Heinrich, T.
, et al.
·
The Cambridge Structural Database
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Works count:
32
Citation count:
764
H-index:
11
I10-index:
11
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