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Author

Swathi Sujatha-Bhaskar

Institution: Genentech
Observed institution: Genentech
OpenAlex ID: A5063108526
Discovery of GDC-0077 (Inavolisib), a Highly Selective Inhibitor and Degrader of Mutant PI3Kα
2022 · Emily J. Hanan, Marie-Gabrielle Braun, et al. · Journal of Medicinal Chemistry · 167
RIP1 inhibition blocks inflammatory diseases but not tumor growth or metastases
2019 · Snahel Patel, Joshua D. Webster, et al. · Cell Death and Differentiation · 152
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NF-κB inducing kinase is a therapeutic target for systemic lupus erythematosus
2018 · Hans D. Brightbill, Eric Suto, et al. · Nature Communications · 132
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Overcoming Preclinical Safety Obstacles to Discover (S)-N-((1,2,3,5,6,7-Hexahydro-s-indacen-4-yl)carbamoyl)-6-(methylamino)-6,7-dihydro-5H-pyrazolo[5,1-b][1,3]oxazine-3-sulfonamide (GDC-2394): A Potent and Selective NLRP3 Inhibitor
2022 · Christopher McBride, Lynnie Trzoss, et al. · Journal of Medicinal Chemistry · 95
Structure-Based Design of Tricyclic NF-κB Inducing Kinase (NIK) Inhibitors That Have High Selectivity over Phosphoinositide-3-kinase (PI3K)
2016 · Georgette M. Castanedo, Nicole Blaquiere, et al. · Journal of Medicinal Chemistry · 65
Scaffold-Hopping Approach To Discover Potent, Selective, and Efficacious Inhibitors of NF-κB Inducing Kinase
2018 · Nicole Blaquiere, Georgette M. Castanedo, et al. · Journal of Medicinal Chemistry · 57
The kinase IRAK4 promotes endosomal TLR and immune complex signaling in B cells and plasmacytoid dendritic cells
2020 · Cesar A. Corzo, Eugene Varfolomeev, et al. · Science Signaling · 41
Development of Potent and Selective Pyrazolopyrimidine IRAK4 Inhibitors
2019 · Marian C. Bryan, Joy Drobnick, et al. · Journal of Medicinal Chemistry · 34
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Discovery of Potent Benzolactam IRAK4 Inhibitors with Robust in Vivo Activity
2019 · Naomi S. Rajapaksa, Alberto Gobbi, et al. · ACS Medicinal Chemistry Letters · 27
A high affinity recombinant antibody to the human EphA3 receptor with enhanced ADCC activity
2014 · Nenad Tomasevic, Kenneth Luehrsen, et al. · Growth Factors · 12
Filling a nick in NIK: Extending the half-life of a NIK inhibitor through structure-based drug design
2023 · James J. Crawford, Jianwen Feng, et al. · Bioorganic & Medicinal Chemistry Letters · 7
Discovery of Clinical Candidate GDC-8264, a Novel, Potent and Selective RIP1 Inhibitor for Amelioration of Tissue Damage and the Treatment of Inflammatory Diseases
2025 · Snahel Patel, Huifen Chen, et al. · Journal of Medicinal Chemistry · 5
High throughput screening of IRAK4 small molecule inhibitors in TLR ligand stimulated whole blood
2018 · Swathi Sujatha-Bhaskar, Zhiyu Huang, et al. · The Journal of Immunology · 1
Selective inhibition of NF-kB inducing kinase (NIK) is therapeutically efficacious in IFNα-accelerated lupus nephritis prone mice
2017 · Hans D Brightbill, Eric Suto, et al. · The Journal of Immunology · 1
TPL2 kinase action and control of inflammation
2020 · Daqi Xu, Youngsu Kwon, et al. · The Journal of Immunology
Works count: 15
Citation count: 796
H-index: 10
I10-index: 10
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