2017 · Tyrosine kinase inhibitor (TKI)-induced thyroid dysfunction is attributed to multiple mechanisms, including immune destruction. Autoimmune thyroid disease can be associated with treatment response in cancer immunotherapy trials. The importance of thyroid dysfunction during TKI therapy to cancer prognosis is unclear. This study analyzes the pattern and significance of hypothyroidism during TKI therapy. A retrospective cohort study of adult patients with advanced non-thyroid cancer treated with TKI and available thyroid function testing (TFT), et al. · Thyroid · 27