Author

Jaya Gautam

Observed institutions: Yeungnam University, McMaster University

OpenAlex ID: A5064470719

GDF15 promotes weight loss by enhancing energy expenditure in muscle

2023 · Dongdong Wang, Logan K. Townsend, et al. · Nature · 264

Tryptophan hydroxylase 1 and 5-HT7 receptor preferentially expressed in triple-negative breast cancer promote cancer progression through autocrine serotonin signaling

2016 · Jaya Gautam, Suhrid Banskota, et al. · Molecular Cancer · 127

PDF

Metformin-induced reductions in tumor growth involves modulation of the gut microbiome

2022 · Lindsay A. Broadfield, Amna Saigal, et al. · Molecular Metabolism · 62

Down-regulation of cathepsin S and matrix metalloproteinase-9 via Src, a non-receptor tyrosine kinase, suppresses triple-negative breast cancer growth and metastasis

2018 · Jaya Gautam, Suhrid Banskota, et al. · Experimental & Molecular Medicine · 61

PDF

Inhibition of tumor growth and angiogenesis of tamoxifen‑resistant breast cancer cells by ruxolitinib, a selective JAK2 inhibitor

2019 · Ji Kim, Jaya Gautam, et al. · Oncology Letters · 60

PDF

ACLY inhibition promotes tumour immunity and suppresses liver cancer

2025 · Jaya Gautam, Jianhan Wu, et al. · Nature · 54

Salicylates Ameliorate Intestinal Inflammation by Activating Macrophage AMPK

2020 · Suhrid Banskota, Huaqing Wang, et al. · Inflammatory Bowel Diseases · 54

Up-regulation of cathepsin S expression by HSP90 and 5-HT7 receptor-dependent serotonin signaling correlates with triple negativity of human breast cancer

2016 · Jaya Gautam, Young Kyung Bae, et al. · Breast Cancer Research and Treatment · 53

Serotonin disturbs colon epithelial tolerance of commensal E. coli by increasing NOX2-derived superoxide

2017 · Suhrid Banskota, Sushil Chandra Regmi, et al. · Free Radical Biology and Medicine · 38

BJ-1108, a 6-Amino-2,4,5-Trimethylpyridin-3-ol Analog, Inhibits Serotonin-Induced Angiogenesis and Tumor Growth through PI3K/NOX Pathway

2016 · Suhrid Banskota, Jaya Gautam, et al. · PLoS ONE · 36

PDF

Fatty Acids Increase GDF15 and Reduce Food Intake Through a GFRAL Signaling Axis

2023 · Dongdong Wang, Maria Joy Therese Jabile, et al. · Diabetes · 29

PDF

5-Hydroxy-7-azaindolin-2-one, a novel hybrid of pyridinol and sunitinib: design, synthesis and cytotoxicity against cancer cells

2016 · Sajita Shah, Chaemin Lee, et al. · Organic & Biomolecular Chemistry · 29

4‐Hydroxynonenal‐induced GPR109A (HCA2 receptor) activation elicits bipolar responses, Gαi‐mediated anti‐inflammatory effects and Gβγ‐mediated cell death

2018 · Jaya Gautam, Suhrid Banskota, et al. · British Journal of Pharmacology · 25

Dual inhibition of ACLY and ACSS2 by EVT0185 reduces steatosis, hepatic stellate cell activation, and fibrosis in mouse models of MASH

2026 · Fiorella Di Pastena, Jaya Gautam, et al. · Cell Metabolism · 22

Inhibition of NADPH Oxidase (NOX) 2 Mitigates Colitis in Mice with Impaired Macrophage AMPK Function

2023 · Suhrid Banskota, Huaqing Wang, et al. · Biomedicines · 17

PDF

Dual Inhibition of NOX2 and Receptor Tyrosine Kinase by BJ-1301 Enhances Anticancer Therapy Efficacy via Suppression of Autocrine-Stimulatory Factors in Lung Cancer

2017 · Jaya Gautam, Jin-Mo Ku, et al. · Molecular Cancer Therapeutics · 16

Synthesis and antiangiogenic activity of 6-amido-2,4,5-trimethylpyridin-3-ols

2014 · Hyunji Lee, Suhrid Banskota, et al. · Bioorganic & Medicinal Chemistry Letters · 16

Anti-angiogenic activity of macrolactin A and its succinyl derivative is mediated through inhibition of class I PI3K activity and its signaling

2014 · Youra Kang, Sushil Chandra Regmi, et al. · Archives of Pharmacal Research · 15

Antitumor effect of 3-(quinolin-2-ylmethylene)-4,6-dimethyl-5-hydroxy-7-azaoxindole down-regulating the Gas6-Axl axis

2023 · Dawon Bae, Prakash Chaudhary, et al. · European Journal of Medicinal Chemistry · 14

Protective effects of 6-ureido/thioureido-2,4,5-trimethylpyridin-3-ols against 4-hydroxynonenal-induced cell death in adult retinal pigment epithelial-19 cells

2017 · Dawon Bae, Jaya Gautam, et al. · Bioorganic & Medicinal Chemistry Letters · 13

Ameliorating effect of TI-1-162, a hydroxyindenone derivative, against TNBS-induced rat colitis is mediated through suppression of RIP/ASK-1/MAPK signaling

2018 · Pallavi Gurung, Suhrid Banskota, et al. · European Journal of Pharmacology · 9

Antitumor activity of BJ-1207, a 6-amino-2,4,5-trimethylpyridin-3-ol derivative, in human lung cancer

2018 · Jaya Gautam, Suhrid Banskota, et al. · Chemico-Biological Interactions · 5

GDF15 suppresses liver inflammation independently of weight loss through neuroendocrine glucocorticoid signaling

2026 · Dongdong Wang, Maria Joy Therese Jabile, et al. · Cell Metabolism · 2

Inhibiting peripheral serotonin activates liver AMPK and reduces monocyte-derived macrophages and fibrosis

2025 · Battsetseg Batchuluun, Tinne Thoné, et al. · Cell Reports · 2

Salsalate improves the anti-tumor efficacy of lenvatinib in MASH-driven hepatocellular carcinoma

2025 · Evangelia E. Tsakiridis, Elham Ahmadi, et al. · JHEP Reports

PDF

Works count: 52

Citation count: 1,023

H-index: 16

I10-index: 20