Author

Maria João Bonifácio

Observed names: Bonifácio, Maria, M J Bonifácio, M. J. Bonifácio, M. J. Bonifácio, M.-J. Bonifacio, M.J. Bonifacio, M.J. Bonifácio, MARIA JOÃO BONIFÁCIO, Maria Bonifácio, Maria J Bonifácio, Maria J. Bonifácio, Maria Joao Bonifacio, Maria João Bonifácio, Maria-Joao Bonifacio, Maria‐Joao Bonifacio, Maria‐João Bonifácio

Institution: Bial (Portugal)

Observed institutions: Bial (Portugal), Universidade do Porto, Hospital de Santo António, Instituto de Biologia Experimental e Tecnológica, Universidade Nova de Lisboa

ORCID: 0000-0002-4782-4686

Observed ORCID: 0000-0002-4782-4686

OpenAlex ID: A5064879720

Catechol‐ O ‐methyltransferase and Its Inhibitors in Parkinson's Disease

2007 · Maria João Bonifácio, P. Nuno Palma, et al. · CNS Drug Reviews · 214

Discovery of a Long-Acting, Peripherally Selective Inhibitor of Catechol-O-methyltransferase

2010 · László E. Kiss, Humberto S. Ferreira, et al. · Journal of Medicinal Chemistry · 169

Eslicarbazepine and the enhancement of slow inactivation of voltage-gated sodium channels: A comparison with carbamazepine, oxcarbazepine and lacosamide

2014 · Simon Hebeisen, Nuno Pires, et al. · Neuropharmacology · 134

Interaction of the Novel Anticonvulsant, BIA 2‐093, with Voltage‐Gated Sodium Channels: Comparison with Carbamazepine

2001 · M. J. Bonifácio, R. D. Sheridan, et al. · Epilepsia · 95

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Kinetics and Crystal Structure of Catechol-O-Methyltransferase Complex with Co-Substrate and a Novel Inhibitor with Potential Therapeutic Application

2002 · Maria João Bonifácio, Margarida Archer, et al. · Molecular Pharmacology · 92

Targeting pharmacoresistant epilepsy and epileptogenesis with a dual-purpose antiepileptic drug

2014 · Anna Doeser, Gesa Dickhof, et al. · Brain · 89

Opicapone: a short lived and very long acting novel catechol‐ O ‐methyltransferase inhibitor following multiple dose administration in healthy subjects

2013 · José Francisco Rocha, Luis Almeida, et al. · British Journal of Clinical Pharmacology · 89

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Pharmacokinetics, Pharmacodynamics and Tolerability of Opicapone, a Novel Catechol-O-Methyltransferase Inhibitor, in Healthy Subjects: Prediction of Slow Enzyme–Inhibitor Complex Dissociation of a Short-Living and Very Long-Acting Inhibitor

2012 · Luis Almeida, José Francisco Rocha, et al. · Clinical Pharmacokinetics · 88

Eslicarbazepine acetate for the treatment of focal epilepsy: an update on its proposed mechanisms of action

2015 · Patrício Soares‐da‐Silva, Nuno Pires, et al. · Pharmacology Research & Perspectives · 82

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Pharmacological profile of opicapone, a third‐generation nitrocatechol catechol‐ O ‐methyl transferase inhibitor, in the rat

2014 · M J Bonifácio, L Torrão, et al. · British Journal of Pharmacology · 55

Computation of the binding affinities of catechol‐O‐methyltransferase inhibitors: Multisubstate relative free energy calculations

2012 · P. Nuno Palma, Maria João Bonifácio, et al. · Journal of Computational Chemistry · 54

Comparative Study of ortho- and meta-Nitrated Inhibitors of Catechol-O-methyltransferase: Interactions with the Active Site and Regioselectivity of O-Methylation

2006 · P.N. Palma, M.L. Rodrigues, et al. · Molecular Pharmacology · 53

Molecular Modeling and Metabolic Studies of The Interaction of Catechol-O-Methyltransferase and a New Nitrocatechol Inhibitor

2003 · P.N. Palma, M.J. Bonifácio, et al. · Drug Metabolism and Disposition · 44

Brain and peripheral pharmacokinetics of levodopa in the cynomolgus monkey following administration of opicapone, a third generation nitrocatechol COMT inhibitor

2013 · M.J. Bonifácio, J.S. Sutcliffe, et al. · Neuropharmacology · 41

Organ-Specific Overexpression of Renal LAT2 and Enhanced Tubular l -DOPA Uptake Precede the Onset of Hypertension

2003 · Maria João Pinho, Pedro Gomes, et al. · Hypertension · 34

Kinetic inhibitory profile of BIA 3-202, a novel fast tight-binding, reversible and competitive catechol-O-methyltransferase inhibitor

2003 · Maria João Bonifácio, Maria Augusta Vieira-Coelho, et al. · European Journal of Pharmacology · 31

Blood pressure-decreasing effect of etamicastat alone and in combination with antihypertensive drugs in the spontaneously hypertensive rat

2014 · Bruno Igreja, Nuno Miguel Pires, et al. · Hypertension Research · 29

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Design, synthesis, and structure–activity relationships of 1,3,4-oxadiazol-2(3H)-ones as novel FAAH inhibitors

2011 · László E. Kiss, Humberto S. Ferreira, et al. · MedChemComm · 28

Evaluation of MutS and Mut+ Pichia pastoris Strains for Membrane-Bound Catechol-O-Methyltransferase Biosynthesis

2015 · A. Q. Pedro, D. Oppolzer, et al. · Applied Biochemistry and Biotechnology · 26

Human Metabolism of Nebicapone (BIA 3-202), a Novel Catechol-O-Methyltransferase Inhibitor: Characterization of in Vitro Glucuronidation

2006 · A.I. Loureiro, M.J. Bonifácio, et al. · Drug Metabolism and Disposition · 26

Third-Generation Solid Dispersion Through Lyophilization Enhanced Oral Bioavailability of Resveratrol

2024 · Hugo Almeida, Bárbara Ferreira, et al. · ACS Pharmacology & Translational Science · 25

Discovery of a Potent, Long‐Acting, and CNS‐Active Inhibitor (BIA 10‐2474) of Fatty Acid Amide Hydrolase

2018 · László E. Kiss, Alexandre Beliaev, et al. · ChemMedChem · 25

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Single‐Dose Tolerability, Pharmacokinetics, and Pharmacodynamics of Etamicastat (BIA 5–453), a New Dopamine β‐Hydroxylase Inhibitor, in Healthy Subjects

2011 · José Francisco Rocha, Manuel Vaz‐Da‐Silva, et al. · The Journal of Clinical Pharmacology · 25

Synthesis and Biological Evaluation of a Novel Series of “Ortho-Nitrated” Inhibitors of Catechol- O -methyltransferase

2005 · David A. Learmonth, Maria João Bonifácio, et al. · Journal of Medicinal Chemistry · 24

Kinetics of Rat Brain and Liver Solubilized Membrane-Bound Catechol-O-Methyltransferase

2000 · Maria João Bonifácio, Maria Augusta Vieira-Coelho, et al. · Archives of Biochemistry and Biophysics · 24

Works count: 104

Citation count: 2,097

H-index: 24

I10-index: 49