Author

Peter B. Sampson

Observed names: P. SAMPSON, P. Sampson, P.B. Sampson, Peter B Sampson, Peter Sampson, Sampson, Peter

Institution: Agora

Observed institutions: University Health Network, Howard Hughes Medical Institute, University of Waterloo, Eli Lilly (United States), University of Oregon, Princess Margaret Cancer Centre, Albany Molecular Research (United States), MaRS, Agora, Campbell Family Institute for Breast Cancer Research, Saint Mary's University

ORCID: 0000-0003-4947-2319

Observed ORCID: 0000-0003-4947-2319

OpenAlex ID: A5065342264

The Discovery of Polo-Like Kinase 4 Inhibitors: Identification of (1R,2S)-2-(3-((E)-4-(((cis)-2,6-Dimethylmorpholino)methyl)styryl)-1H-indazol-6-yl)-5′-methoxyspiro[cyclopropane-1,3′-indolin]-2′-one (CFI-400945) as a Potent, Orally Active Antitumor Agent

2014 · Peter B. Sampson, Yong Liu, et al. · Journal of Medicinal Chemistry · 186

The Discovery of Polo-Like Kinase 4 Inhibitors: Design and Optimization of Spiro[cyclopropane-1,3′[3H]indol]-2′(1′H)-ones as Orally Bioavailable Antitumor Agents

2014 · Peter B. Sampson, Yong Liu, et al. · Journal of Medicinal Chemistry · 117

Insights into the Mechanism of Escherichia coli Methionine Aminopeptidase from the Structural Analysis of Reaction Products and Phosphorus-Based Transition-State Analogues,

1999 · W. Todd Lowther, Yan Zhang, et al. · Biochemistry · 103

Discovery of Pyrazolo[1,5-a]pyrimidine TTK Inhibitors: CFI-402257 is a Potent, Selective, Bioavailable Anticancer Agent

2016 · Yong Liu, Radoslaw Laufer, et al. · ACS Medicinal Chemistry Letters · 91

Phytocannabinoid Pharmacology: Medicinal Properties of Cannabis sativa Constituents Aside from the “Big Two”

2020 · Peter B. Sampson · Journal of Natural Products · 79

The Discovery of PLK4 Inhibitors: (E)-3-((1H-Indazol-6-yl)methylene)indolin-2-ones as Novel Antiproliferative Agents

2013 · Radoslaw Laufer, Bryan Forrest, et al. · Journal of Medicinal Chemistry · 79

Methionine In and Out of Proteins: Targets for Drug Design

2002 · Mark Vaughan, Peter Sampson, et al. · Current Medicinal Chemistry · 79

Use of Analogues of Methionine and Methionyl Adenylate to Sample Conformational Changes During Catalysis in Escherichia coli Methionyl-tRNA Synthetase

2003 · Thibaut Crepin, Emmanuelle Schmitt, et al. · Journal of Molecular Biology · 76

Safety and tolerability of CFI-400945, a first-in-class, selective PLK4 inhibitor in advanced solid tumours: a phase 1 dose-escalation trial

2019 · Zachary W. Veitch, David W. Cescon, et al. · British Journal of Cancer · 73

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Synthesis and Structure−Activity Relationships of Novel Arylpiperazines as Potent and Selective Agonists of the Melanocortin Subtype-4 Receptor

2004 · Timothy I. Richardson, Paul L. Ornstein, et al. · Journal of Medicinal Chemistry · 62

The Discovery of Orally Bioavailable Tyrosine Threonine Kinase (TTK) Inhibitors: 3-(4-(heterocyclyl)phenyl)-1H-indazole-5-carboxamides as Anticancer Agents

2015 · Yong Liu, Yunhui Lang, et al. · Journal of Medicinal Chemistry · 57

Synthesis of an α-Aminophosphonate Nucleoside as an Inhibitor of S-Adenosyl-l-Homocysteine Hydrolase

2002 · Jennifer A Steere, Peter B Sampson, et al. · Bioorganic & Medicinal Chemistry Letters · 38

Design and optimization of (3-aryl-1H-indazol-6-yl)spiro[cyclopropane-1,3′-indolin]-2′-ones as potent PLK4 inhibitors with oral antitumor efficacy

2016 · Sze-Wan Li, Yong Liu, et al. · Bioorganic & Medicinal Chemistry Letters · 33

2,3,4,5-Tetrahydro-1H-pyrido[2,3-b and e][1,4]diazepines as inhibitors of the bacterial enoyl ACP reductase, FabI

2009 · Jailall Ramnauth, Mathew D. Surman, et al. · Bioorganic & Medicinal Chemistry Letters · 28

Spiro-naphthyridinone piperidines as inhibitors of S. aureus and E. coli enoyl-ACP reductase (FabI)

2009 · Peter B. Sampson, Christine Picard, et al. · Bioorganic & Medicinal Chemistry Letters · 23

Oxidative Deprotection of Diphenylmethylamines

1999 · Peter B. Sampson, John F. Honek · Organic Letters · 21

Investigation of Bioisosteric Effects on the Interaction of Substrates/ Inhibitors with the Methionyl-tRNA Synthetase from Escherichia coli

2005 · M. Vaughan, P. Sampson, et al. · Medicinal Chemistry · 11

Physical and Pharmacokinetic Characterization of Soluvec™, a novel, solvent-free Aqueous Ivermectin Formulation

2023 · Richa Mandalaywala, Azhar Rana, et al. · Therapeutic Delivery · 8

Abstract CT066: First-in-human phase I trial of the oral PLK4 inhibitor CFI-400945 in patients with advanced solid tumors

2016 · Philippe L. Bedard, David W. Cescon, et al. · Cancer Research · 8

Abstract LB-215: Inhibition of Polo-like kinase 4 as an anti-cancer strategy

2011 · Jacqueline Mason, Sam Wei, et al. · Cancer Research · 7

Syntheses and kinetic evaluation of hydroxamate-based peptide inhibitors of glyoxalase I

1998 · Hoa D. Ly, L.Clugston Susan, et al. · Bioorganic & Medicinal Chemistry Letters · 7

Electrophilic acetylation and bromination reactions of benzo[b]naphtho[2,3‐e][1,4]dioxin

1992 · Adam Piórko, Michelle Crook, et al. · Journal of Heterocyclic Chemistry · 4

1,4‐Benzodioxin‐2(3H)‐one and some of its derivatives

1994 · Peter Sampson, Michelle Crook, et al. · Journal of Heterocyclic Chemistry · 3

Some nitro derivatives of 1,4‐benzodioxino[2,3‐b]pyridine. Crystal and molecular structure of 2,7,8‐trinitro‐1,4‐benzodioxino[2,3‐b]pyridine

1994 · Adam Piórko, Sean Christie, et al. · Journal of Heterocyclic Chemistry · 2

Methionyl-trna Synthetase From Escherichia Coli Complexed With Methionine and Adenosine

2003 · T. Crepin, E. Schmitt, et al. · Worldwide Protein Data Bank · 1

Works count: 51

Citation count: 1,197

H-index: 16

I10-index: 17